@article {67354,
	title = {Assessment of coagulation and fibrinolysis in children with chronic liver disease.},
	journal = {Blood coagulation \& fibrinolysis : an international journal in haemostasis and thrombosis},
	volume = {24},
	year = {2013},
	note = {n/a},
	month = {2013 Mar},
	pages = {113-7},
	abstract = {<p>We aimed at assessing the coagulation profile and detecting early evidence of fibrinolysis in pediatric patients with chronic liver disease. Seventy-six patients (40 boys) with a mean age of 9.8 {\textpm} 3.4 years suffering from chronic liver disease were enrolled in this study. They were followed up in the Pediatric Hepatology Unit, Cairo University Children{\textquoteright}s Hospital. Thirty healthy children were included as controls. Patients were classified etiologically into four groups: chronic viral hepatitis, autoimmune hepatitis, miscellaneous and cryptogenic groups. Investigations to detect coagulopathy were done for all patients and controls: prothrombin time (PT), activated partial thromboplastin time, fibrinogen, fibrinogen degradation products, and D-dimer and complete blood count. Liver functions were done for all patient groups. A significantly lower platelet count, prolonged prothrombin time, with prolonged aPTT time was detected in all patients compared with controls (P \&lt; 0.001). The fibrinogen level showed no significant difference between patients and controls. D-dimer level was significantly higher in the miscellaneous and cryptogenic groups when compared to other patient groups and control group (P \&lt; 0.001). Significantly higher D-dimer levels were detected in patients with liver cirrhosis of child class A and B compared with noncirrhotic and control groups (P \&lt; 0.001). D-dimer correlated positively with PT (r = 0.290, P = 0.003), and negatively with platelet count (r = -0.324, P = 0.001) and prothrombin concentration (r = -0.270, P = 0.018). Fibrinolytic activity, as evidenced by high D-dimer, was detected in pediatric patients with chronic liver disease particularly if cirrhotic.</p>
},
	keywords = {Blood Coagulation, Blood Coagulation Factors, Case-Control Studies, Child, Chronic Disease, Female, Fibrinolysis, Humans, Liver Cirrhosis, Liver Diseases, Liver Function Tests, Male, Prospective Studies},
	issn = {1473-5733},
	doi = {10.1016/j.dsx.2013.10.008},
	author = {Rokaya El-Sayed and Hanaa El-Karaksy and Mona El-Raziky and Manal El-Hawary and Nehal El Koofy and Heba Helmy and Mona Fahmy}
}
