Cromwell, E. A., J. C. P. Osborne, T. R. Unnasch, M. - G. Basáñez, K. M. Gass, K. A. Barbre, E. Hill, K. B. Johnson, K. M. Donkers, S. Shirude, et al., "Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning.", PLoS neglected tropical diseases, vol. 15, issue 7, pp. e0008824, 2021. Abstract

Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys will need to be conducted across all implementation units (IUs) for which endemicity status is currently unknown. Using boosted regression tree models with optimised hyperparameter selection, we estimated environmental suitability for onchocerciasis at the 5 × 5-km resolution across Africa. In order to classify IUs that include locations that are environmentally suitable, we used receiver operating characteristic (ROC) analysis to identify an optimal threshold for suitability concordant with locations where onchocerciasis has been previously detected. This threshold value was then used to classify IUs (more suitable or less suitable) based on the location within the IU with the largest mean prediction. Mean estimates of environmental suitability suggest large areas across West and Central Africa, as well as focal areas of East Africa, are suitable for onchocerciasis transmission, consistent with the presence of current control and elimination of transmission efforts. The ROC analysis identified a mean environmental suitability index of 0·71 as a threshold to classify based on the location with the largest mean prediction within the IU. Of the IUs considered for mapping surveys, 50·2% exceed this threshold for suitability in at least one 5 × 5-km location. The formidable scale of data collection required to map onchocerciasis endemicity across the African continent presents an opportunity to use spatial data to identify areas likely to be suitable for onchocerciasis transmission. National onchocerciasis elimination programmes may wish to consider prioritising these IUs for mapping surveys as human resources, laboratory capacity, and programmatic schedules may constrain survey implementation, and possibly delaying MDA initiation in areas that would ultimately qualify.

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YOUSOF, H. E. B. A. T. - A. L. L. A. H. S. A., S. H. El-Sayed, E. Elfar, and M. Khater, Repurposing of Anti-malarial SynriamTM and testing its efficacy against Egyptian strain of Schistosoma hematobium, , 2020. Abstract
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Reiner Jr, R. C., S. I. Hay, K. E. Wiens, A. Deshpande, M. M. Baumann, P. A. Lindstedt, B. F. Blacker, C. E. Troeger, L. Earl, and S. B. Munro, "Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017", The Lancet: Elsevier, 2020. Abstract
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Khater, M. M., and E. M. A. N. I. ELFAR, "UNDERWEIGHT AS A RISK FACTOR FOR MULTIPARASITISM AND ITS CLINICAL SIGNIFICANCE AMONG EGYPTIAN CHILDREN", Journal of the Egyptian Society of Parasitology, vol. 49, issue 2: The Egyptian Society of Parasitology, pp. 337-344, 2019. Abstract
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El-Sayed, S. H., H. E. B. A. T. - A. L. L. A. H. S. A. YOUSOF, and M. O. N. A. M. M. KHATER, "ASSESSMENT OF THE EFFECTOR ANTIBODIES AGAINST SCHISTOSOMA MANSONI AND THEIR IMPACT ON MEFLOQUINE EFFICACY", Journal of the Egyptian Society of Parasitology, vol. 48, issue 1: The Egyptian Society of Parasitology, pp. 175-181, 2018. Abstract
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