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Elbendary, A., M. R. E. Abdel-Halim, and G. Ragab, "Updates in cutaneous manifestations of systemic vasculitis.", Current opinion in rheumatology, vol. 34, issue 1, pp. 25-32, 2022. Abstract

PURPOSE OF REVIEW: The main purpose of this review is to present newly reported cutaneous manifestations of systemic vasculitis, updates in investigations to verify systemic involvement in cases with cutaneous vasculitis and new therapeutic guidelines. The spectrum of COVID-19-related vasculitis is also covered.

RECENT FINDINGS: Only a few reports highlighted new cutaneous presentations or associations with some systemic vasculitic entities. For example, the association of inflammatory disorders with Takayasu arteritis, the importance of considering Kawasaki disease in febrile children with erythema nodosum, the development of necrotic ulcers on fingers and toes in Behçet's disease and the possible presence of polyarteritis nodosa-like pathological features in vulvar ulcers of Behçet's disease. New attempts to classify cutaneous manifestations of giant cell arteritis (GCA) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and the diagnostic investigations for cutaneous vasculitis cases to verify systemic involvement are discussed. Treatment of systemic vasculitis with cutaneous vasculitis should be tailored according to disease status. A plethora of reports in the past 2 years focused on the broad spectrum of COVID-19 vasculitic manifestations.

SUMMARY: Although newly reported cutaneous manifestations of systemic vasculitis are relatively uncommon, the plethora of reports in the past 2 years on COVID-19 vasculitis necessitates the expansion of the classification of vasculitis associated with probable cause to include severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) vasculitis.

Ragab, G., M. T. Hegazy, M. Ali, M. R. E. Abdel-Halim, and X. Puéchal, "Three Patterns of Cutaneous Involvement in Granulomatosis with Polyangiitis.", Journal of advanced research, vol. 24, pp. 311-315, 2020. Abstract

Background: Skin involvement in granulomatosis with polyangiitis (GPA) is common and can appear as an initial presentation of the disease or more commonly through its course.

Case presentation: We report a case of a 24-year-old male patient, previously diagnosed as having GPA, admitted with fever, hemoptysis, generalized hemorrhagic blisters associated with arthralgia, fatigue, myalgia, nasal crusting, and vertigo. Three weeks prior to admission, he developed erythematous papules on both elbows, and purpuric papules on both lower limbs. Histopathological examination revealed: interstitial granulomatous dermatitis (elbows) and foci of dermal hemorrhage, foci of interstitial histiocytes and zones of altered necrobiotic collagen (lower limbs) consistent with cutaneous lesions of GPA. Two weeks later, his rash progressed to widespread purpura associated with hemorrhagic blisters. Another biopsy revealed leukocytoclastic vasculitis with fibrinoid necrosis of the vessel walls associated with perivascular infiltrate of neutrophils, nuclear dust and extravasated erythrocytes without an associated granulomatous inflammation or necrobiosis. The constellation of the results of the three biopsies together with clinical correlation pointed to a flare of GPA.

Conclusion: Skin involvement in GPA is quite common, and it can manifest in different forms in the same patient. Our patient developed three different skin pathologies within a short period of time.

El-Mofty, M., M. El-Darouti, H. RASHEED, D. A. Bassiouny, M. Abdel-Halim, N. S. Zaki, G. El-Hanafy, H. El-Hadidi, O. Azzam, A. El-Ramly, et al., "Sulfasalazine and pentoxifylline in psoriasis: a possible safe alternative", Journal of Dermatological Treatment, vol. 22, no. 1: Informa Healthcare USA on behalf of Informa UK Ltd. London, pp. 31–37, 2011. Abstract
El Darouti, M., S. A. Marzouk, M. Fawzi, M. Rabie, A. El Tawdi, and M. Abdel Azziz, "Reticulate acropigmentation of Dohi: a report of two new associations", International journal of dermatology, vol. 43, no. 8: Wiley Online Library, pp. 595–596, 2004. Abstract
El-Darouti, M. A., S. A. Marzouk, M. H. M. El-Komy, and M. RE, "Preliminary Clinical, Histopathological and Laboratory Study of Cases Presenting with Pruriginous Edematous Excoriated Papular Eruption (Subacute Prurigo)", Kasr Al Aini Medical Journal, vol. 13, no. 1, pp. 7–13, 2007. Abstract
Esmat, S. M., M. R. E. Abdel-Halim, H. I. GAWDAT, M. Kamel, A. E. Ramly, K. Helmy, and S. M. Esmat, "Persistent Pixel Stamping Marks: a novel complication of fractional CO laser in scar treatment.", Lasers in medical science, 2019 Jan 04. Abstract

Fractional CO laser rejuvenation of scars offers a high safety profile. Laser marks usually disappear clinically within 1 week. The authors observed occasional persistence of the laser marks on the scar surface. The purpose of this study is to report the incidence and to describe the clinical, dermoscopic, and histological features of a novel observed complication of fractional CO laser scar rejuvenation "Persistent Pixel Stamping Marks (PPSM)".One hundred seventy-one cases were consecutively recruited from patients assigned for fractional CO laser scar rejuvenation. Patients who developed the phenomenon 1 month post laser session were recorded and subjected to clinical photography, dermoscopy, and optical coherence tomography (OCT) as well as a 4-mm punch biopsy from pixelated scars. The evolution of PPSM was followed up for 6 months. PPSM developed in 16 patients (9.4%), 15 of which were post burn hypertrophic scars. PPSM was significantly related to darker skin type, darker scar color, and longer scar duration. Histopathological findings included characteristic holes in stratum corneum and superficial dermis, thick collagen bundles perpendicular to the skin surface with loss of elastic tissue, focal interface changes, and triangular focus of fibroblastic proliferation. The marks disappeared in 5 and lasted in 11 patients. Their longevity was significantly related to longer dwell times and lower densities. PPSM represent miniature scarring at the sites of the microscopic thermal zones or a sign of their delayed healing. They tend to follow fractional CO laser resurfacing of hyperpigmented, long-standing burn scars. Longer dwell times and lower densities make them last longer.

El Darouti, M. A., S. A. Marzouk, H. M. Mashaly, E. A. El Nabarawi, M. R. E. Abdel-Halim, M. M. El Komy, V. G. Hafez, A. H. M. Reheem, and K. M. Moussa, "Lipedema and lipedematous alopecia: report of 10 new cases (vol 17, pg 351, 2007)", EUROPEAN JOURNAL OF DERMATOLOGY, vol. 17, no. 5: JOHN LIBBEY EUROTEXT LTD 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE, pp. 360–360, 2007. Abstract
RASHEED, H., M. M. T. Fawzi, M. R. E. Abdel-Halim, A. M. Eissa, N. M. Salem, and S. Mahfouz, "Immunohistochemical study of the expression of matrix metalloproteinase-9 in skin lesions of mycosis fungoides", The American Journal of Dermatopathology, vol. 32, no. 2: LWW, pp. 162–169, 2010. Abstract
Abdel-Halim, M., E. El-Nabarawy, M. D. Reham El Nemr, and A. M. Hassan, "Frequency of Hypopigmented Mycosis Fungoides in Egyptian Patients Presenting With Hypopigmented Lesions of the Trunk.", The American Journal of Dermatopathology: LWW, 2015. Abstract
Ragab, M. S., S. M. Essmat, D. A. Bassiounv, M. R. E. Abdel-Halim, H. H. El-Hadidi, N. M. El-Sharkawy, F. M. Ghaleb, and S. M. Al-Maghrabi, Effect of staphylococcal colonization and exotoxin production on apoptosis in atopic dermatitis, , 2005. Abstract


Esmat, S., M. R. E. Abdel-Halim, A. El-Tawdy, M. M. Fawzy, A. Ragheb, and N. Hasan, "Does increasing the pulse duration increase the efficacy of long pulsed Nd: YAG laser assisted hair removal? A split-chin clinical trial", European Journal of Dermatology, vol. 1, no. 1, pp. 0–0, 2014. Abstract
Abdel-Halim, M. R. E., A. Mahmoud, and G. Ragab, "Cutaneous manifestations of ANCA associated vasculitis", Vessel Plus, vol. 6, 2022.
Shaker, O. G., M. Khairallah, H. M. Rasheed, M. R. Abdel-Halim, O. M. Abu Zeid, A. M. El Tawdi, H. H. El Hadidi, and A. Ashmaui, "Antiangiogenic effect of methotrexate and PUVA on psoriasis", Cell biochemistry and biophysics, vol. 67, no. 2: Springer, pp. 735–742, 2013. Abstract