Publications

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M
Pioltelli, P., P. T. Atkinson, M. Mattar, A. Edrees, H. M. A. Ahmad, A. Laymouna, M. R. E. Abdel-Halim, and G. Ragab, Monoclonal gammopathies with miscellaneous associations, , 2022.
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El-Darouti, M. A., S. A. Marzouk, M. R. E. Abdel-Halim, A. Z. Zidan, and M. M. Fawzy, "Basaloid follicular hamartoma", International journal of dermatology, vol. 44, no. 5: Wiley Online Library, pp. 361–365, 2005. Abstract
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El-Mofty, M., W. Z. Mostafa, R. Yousef, M. R. E. Abdel Halim, M. El Hawary, H. Abdel Kader, S. Assaad, and B. B. Ghannam, "Broadband ultraviolet A in the treatment of psoriasis vulgaris: a randomized controlled trial", International journal of dermatology, 2014. Abstract
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El-Mofty, M., H. El Weshahy, R. Youssef, M. Abdel-Halim, H. Mashaly, and M. El Hawary, "A comparative study of different treatment frequencies of psoralen and ultraviolet A in psoriatic patients with darker skin types (randomized-controlled study)", Photodermatology, photoimmunology & photomedicine, vol. 24, no. 1: Wiley Online Library, pp. 38–42, 2008. Abstract
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FH, S., A. - A. FA, M. NH, A. - H. MRE, E. - N. EA, and K. AM, "Congenital Primary Cutaneous Rhabdomyosarcoma of the Perineum with Mixed Histopathological Features and Unusual Expression of Smooth Muscle Actin: Report of a Case", Clinical Dermatology Open Access Journal, issue 2(1), 2017.
Enany, G. E., N. Nagui, H. Nada, H. A. Abdelkader, I. Sany, A. Nada, M. Mostafa, O. El-Ghanam, and M. R. E. Abdel-Halim, "Crystalglobulinemia: A Rare Presenting Manifestation of Multiple Myeloma.", The American Journal of dermatopathology, 2021. Abstract

ABSTRACT: Crystalglobulinemia (CG) is a rare disorder characterized by crystallization of monoclonal immunoglobulins in the microcirculation leading to multiorgan vascular thrombosis and ischemic injury. The main cause of CG is multiple myeloma. We report a case of a 52-year-old man who presented with widespread necrotizing plaques and ulcerations. A skin biopsy revealed eosinophilic rectangular-shaped crystals occluding the lumina of blood vessels with no associated features of vasculitis. The crystals were Periodic acid-Schiff stain positive. The findings were diagnostic of CG. Extensive work up lead to the discovery of multiple myeloma. Awareness of CG is important because it may be the first presenting manifestation of an underlying serious hematological malignancy.

Abdel-Halim, M. R. E., A. Mahmoud, and G. Ragab, "Cutaneous manifestations of ANCA associated vasculitis", Vessel Plus, vol. 6, 2022.
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Mostafa, N. A., M. Assaf, S. Elhakim, M. R. E. Abdel-Halim, E. El-Nabarawy, and khaled Gharib, "Diagnostic accuracy of immunohistochemical markers in differentiation between basal cell carcinoma and trichoepithelioma in small biopsy specimens.", Journal of cutaneous pathology, vol. 45, issue 11, pp. 807-816, 2018 Nov. Abstract

BACKGROUND: The distinction of trichoepithelioma from basal cell carcinoma in small superficial biopsies is important but often challenging. This has inspired many scientists to test the validity of immunohistochemical markers in the differential diagnosis.

OBJECTIVES: To develop an immunohistochemical protocol that helps in differentiation between both trichoepithelioma (TE) and basal cell carcinoma (BCC) with higher sensitivity and specificity.

METHODS: Using standard immunohistochemical techniques, we examined 10 TEs and 19 BCCs for the expression of CK19, Ki-67, androgen receptors (AR), CD10, and PHLDA1.

RESULTS: Immunoreactivity of AR, Ki-67, and CD10 in tumor cells was significantly higher in BCC than TE with a diagnostic accuracy in BCC of 75.5%, 75.8%, and 79.3% respectively, whereas immunoreactivity of PHLDA1 in tumor cells and stromal CD10 was significantly higher in TE than BCC with a diagnostic accuracy in TE of 100% and 82.8%, respectively. In contrast, immunoreactivity for CK19 showed no statistically significant differences between both tumors.

CONCLUSION: The analysis of CD10, Ki-67, and PHLDA1 can be used as a helpful immunohistochemical panel in the distinction between TE and BCC especially in small and superficial biopsies.

E
El-Komy, M. H. M., N. Shawky, A. Mourad, and M. R. Abdel-Halim, "Erythema gyratum repens-like psoriasis: a case report and review of literature.", International journal of dermatology, 2022.
Mona R.E. Abdel-Halim, Faisal N. Mohammed, K. S. D. A. A. G. E. - D. M. B. S. M. A. A., "Expression of programmed cell death protein 4 in non-melanoma skin cancer compared with psoriasis and normal skin, a preliminary study", JEWDS, vol. 13, no. 2, pp. 77–82, 2016. Abstract
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El-Darouti, M. A., S. A. Fawzi, S. A. Marzook, N. H. El-Eishi, M. R. E. Abdel-Halim, and S. A. Soliman, "Familial gigantic melanocytosis", International journal of dermatology, vol. 44, no. 12: Wiley Online Library, pp. 1010–1015, 2005. Abstract
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El-Darouty, M. A., S. A. Marzouk, M. R. E. Abdel-Halim, M. H. M. El-Komy, and H. M. Mashaly, "Folliculo-sebaceous cystic hamartoma", International journal of dermatology, vol. 40, no. 7: Wiley Online Library, pp. 454–457, 2001. Abstract
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El-Tahlawi, S. M. R., M. R. E. Abdel-Halim, M. A. F. Hamid, K. S. Mohammad, H. Wafai, and A. H. M. S. El-Sayed, "Gene polymorphism and serum levels of insulin-like growth factor-I in Egyptian acne patients", Journal of the Egyptian Women’s Dermatologic Society, vol. 11, no. 1: LWW, pp. 45–49, 2014. Abstract
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El-Darouti, M. A., S. Hussein, S. A. Marzouk, N. Nabil, N. S. Hunter, D. Mahgoub, N. H. El-Eishi, and M. R. E. Abdel-Halim, "Histopathological study of apparently normal skin of patients with leprosy", International journal of dermatology, vol. 45, no. 3: Wiley Online Library, pp. 292–296, 2006. Abstract
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Youssef, R., D. Mahgoub, O. A. Zeid, D. M. Abdel-Halim, M. El-Hawary, M. F. Hussein, M. A. Morcos, D. M. Aboelfadl, H. A. Abdelkader, Y. Abdel-Galeil, et al., "Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study.", The American Journal of dermatopathology, vol. 40, issue 10, pp. 727-735, 2018 Oct. Abstract

Hypopigmented interface T-cell dyscrasia (HITCD) is a distinct form of lymphoid dyscrasia that may progress to hypopigmented mycosis fungoides (HMF). We compared both diseases as regards their CD4/CD8 phenotype and expression of granzyme B and tumor necrosis factor-alpha (TNF-α) and how these are affected by narrow-band UVB (nb-UVB). The study included 11 patients with HITCD and 9 patients with HMF. They received nb-UVB thrice weekly until complete repigmentation or a maximum of 48 sessions. Pretreatment and posttreatment biopsies were stained using anti CD4, CD8, TNF-α, and granzyme B monoclonal antibodies. Epidermal lymphocytes were CD8 predominant in 54.5% and 66.7% of HITCD and HMF cases, respectively, whereas dermal lymphocytes were CD4 predominant in 63.6% and 66.7%, respectively. Significantly, more dermal infiltrate was encountered in HMF (P = 0.041). In both diseases, granzyme B was only expressed in the dermis, whereas TNF-α was expressed both in the epidermis and dermis. No difference existed as regards the number of sessions needed to achieve repigmentation or cumulative nb-UVB dose reached at end of study. (P > 0.05). Narrow-band UVB significantly reduced only the epidermal lymphocytes in both diseases (P ≤ 0.05) with their complete disappearance in 8 (72.7%) HITCD and 6 (66.7%) HMF cases. In both diseases, nb-UVB did not affect granzyme B or TNF-α expression (P > 0.05). In conclusion, both diseases share the same phenotype, with HITCD being a milder form of T-cell dysfunction. In both diseases, epidermal lymphocytes are mainly CD8-exhausted cells lacking cytotoxicity, whereas dermal cells are mostly reactive cells exerting antitumor cytotoxicity. Tumor necrosis factor-alpha mediates hypopigmentation in both diseases and prevents disease progression. Repigmentation after nb-UVB in both diseases occurs before and independently from disappearance of the dermal infiltrate.

I
RASHEED, H., M. M. T. Fawzi, M. R. E. Abdel-Halim, A. M. Eissa, N. M. Salem, and S. Mahfouz, "Immunohistochemical study of the expression of matrix metalloproteinase-9 in skin lesions of mycosis fungoides", The American Journal of Dermatopathology, vol. 32, no. 2: LWW, pp. 162–169, 2010. Abstract
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El-Darouti, M. A., H. M. Mashaly, E. El-Nabarawy, A. M. Eissa, M. R. E. Abdel-Halim, M. M. T. Fawzi, N. H. El-Eishi, S. O. Tawfik, N. S. Zaki, A. Z. Zidan, et al., "Leukocytoclastic vasculitis and necrolytic acral erythema in patients with hepatitis C infection: Do viral load and viral genotype play a role?", Journal of the American Academy of Dermatology, vol. 63, no. 2: Elsevier, pp. 259–265, 2010. Abstract
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El Darouti, M. A., S. A. Marzouk, H. M. Mashaly, E. A. El Nabarawi, M. R. E. Abdel-Halim, M. M. El Komy, V. G. Hafez, A. H. M. Reheem, and K. M. Moussa, "Lipedema and lipedematous alopecia: report of 10 new cases (vol 17, pg 351, 2007)", EUROPEAN JOURNAL OF DERMATOLOGY, vol. 17, no. 5: JOHN LIBBEY EUROTEXT LTD 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE, pp. 360–360, 2007. Abstract
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M
El-Darouti, M. A., S. A. Marzouk, M. Bosseila, O. abu Zeid, O. El-Safouri, A. Zayed, A. El-Ramly, and M. R. E. Abdel-Halim, "Microscopic study of normal skin in cases of mycosis fungoides", International journal of dermatology, vol. 45, no. 9: Wiley Online Library, pp. 1043–1046, 2006. Abstract
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El-Darouti, M. A., S. A. Marzouk, and M. R. E. Abdel-Halim, "Muckle–Wells syndrome: report of six cases with hyperpigmented sclerodermoid skin lesions", International journal of dermatology, vol. 45, no. 3: Wiley Online Library, pp. 239–244, 2006. Abstract
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El-Darouti, M. A., S. A. Marzouk, N. Nabil, M. R. E. Abdel-Halim, M. H. M. El-Komy, and M. Abdel-Latif, "Pachyonychia congenita: treatment of the thickened nails and palmoplantar circumscribed callosities with urea 40% paste", Journal of the European Academy of Dermatology and Venereology, vol. 20, no. 5: Wiley Online Library, pp. 615–617, 2006. Abstract
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El-Darouti, M. A., S. A. Marzouk, M. H. M. El-Komy, and M. RE, "Preliminary Clinical, Histopathological and Laboratory Study of Cases Presenting with Pruriginous Edematous Excoriated Papular Eruption (Subacute Prurigo)", Kasr Al Aini Medical Journal, vol. 13, no. 1, pp. 7–13, 2007. Abstract
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El Darouti, M., S. A. Marzouk, M. Fawzi, M. Rabie, A. El Tawdi, and M. Abdel Azziz, "Reticulate acropigmentation of Dohi: a report of two new associations", International journal of dermatology, vol. 43, no. 8: Wiley Online Library, pp. 595–596, 2004. Abstract
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Shaker, O. G., W. Moustafa, S. Essmat, M. Abdel-Halim, and M. El-Komy, "The role of interleukin-12 in the pathogenesis of psoriasis", Clinical biochemistry, vol. 39, no. 2: Elsevier, pp. 119–125, 2006. Abstract
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El Mofty, M. A., R. M. Youssef, S. O. Tawfic, M. R. E. Abdel Halim, H. Abozeid, O. G. Shaker, and O. M. Mohammad, "Skin and serum levels of calcium, phosphorus and vitamin D3 in uremic pruritus patients before and after broad band ultraviolet B (UVB) phototherapy", Egypt Dermatol Online J, vol. 2, 2006. Abstract
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