Publications

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Journal Article
Shaker, O. G., M. Khairallah, H. M. Rasheed, M. R. Abdel-Halim, O. M. Abu Zeid, A. M. El Tawdi, H. H. El Hadidi, and A. Ashmaui, "Antiangiogenic effect of methotrexate and PUVA on psoriasis", Cell biochemistry and biophysics, vol. 67, no. 2: Springer, pp. 735–742, 2013. Abstract
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El-Hawary, M. S., M. R. E. Abdel-Halim, S. S. Sayed, and H. A. Abdelkader, "Apocytolysis, a proposed mechanism of blister formation in epidermolysis bullosa simplex", Archives of Dermatological Research: Springer Berlin Heidelberg, pp. 1–7, 2015. Abstract
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Esmat, S., M. AbdElhalim, M. Fawzy, S. Nassef, S. Esmat, R. T. Fouly ES, and El, "Are normolipidaemic patients with xanthelasma prone to atherosclerosis?", Clinical and Experimental Dermatology, 2015. Abstract
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Tawfic, S. O., M. R. E. Abdel-Halim, and O. G. Shaker, "Assessment of interleukin-17 in alopecia areata: a case–control pilot study", Journal of the Egyptian Women’s Dermatologic Society, vol. 11, no. 1: LWW, pp. 20–23, 2014. Abstract
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El-Darouti, M. A., S. A. Marzouk, M. R. E. Abdel-Halim, A. Z. Zidan, and M. M. Fawzy, "Basaloid follicular hamartoma", International journal of dermatology, vol. 44, no. 5: Wiley Online Library, pp. 361–365, 2005. Abstract
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El-Mofty, M., W. Z. Mostafa, R. Yousef, M. R. E. Abdel Halim, M. El Hawary, H. Abdel Kader, S. Assaad, and B. B. Ghannam, "Broadband ultraviolet A in the treatment of psoriasis vulgaris: a randomized controlled trial", International journal of dermatology, 2014. Abstract
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Shalaby, S., E. A. El-Nabarawy, M. Assaf, and M. R. E. Abdel Halim, "Causes of acquired erythroderma in adults presenting to a tertiary care centre in Cairo, Egypt", Journal of the Egyptian Women's Dermatologic Society, vol. 12, no. 3: Wolters Kluwer, pp. 162–169, 2015. Abstract
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El-Komy, M. H. M., Y. Azzazi, R. El Naggar, and M. R. E. Abdel-Halim, "Chronic Atrophic Scar-like Plaque: Challenge.", The American Journal of dermatopathology, vol. 44, issue 1, pp. e6-e7, 2022.
Hafez, V. G., M. Bosseila, M. R. E. Abdel Halim, O. G. Shaker, M. Kamal, and H. S. Kareem, "Clinical effects of “pioglitazone”, an insulin sensitizing drug, on psoriasis vulgaris and its co-morbidities, a double blinded randomized controlled trial", Journal of Dermatological Treatment, vol. 26 (3), issue Jun: Informa UK Ltd. London, pp. 208-14, 2015. Abstract

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Osama, R., H. A. Abdelkader, S. Ahmad, and M. R. E. Abdel-Halim, "Clustered yellowish papules on the cheek.", International journal of dermatology, 2020.
Khatery, B. H. M., M. R. E. Abdel-Halim, and S. Adel, "Comedonal Lesions on the Trunk and Proximal Extremities: Challenge.", The American Journal of dermatopathology, vol. Publish Ahead of Print, 2020.
El-Mofty, M., H. El Weshahy, R. Youssef, M. Abdel-Halim, H. Mashaly, and M. El Hawary, "A comparative study of different treatment frequencies of psoralen and ultraviolet A in psoriatic patients with darker skin types (randomized-controlled study)", Photodermatology, photoimmunology & photomedicine, vol. 24, no. 1: Wiley Online Library, pp. 38–42, 2008. Abstract
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Shaker, O., and M. Abdel-Halim, "Connexin 26 in psoriatic skin before and after two conventional therapeutic modalities: methotrexate and PUVA", European Journal of Dermatology, vol. 22, no. 2, pp. 218–224, 2012. Abstract
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Enany, G. E., N. Nagui, H. Nada, H. A. Abdelkader, I. Sany, A. Nada, M. Mostafa, O. El-Ghanam, and M. R. E. Abdel-Halim, "Crystalglobulinemia: A Rare Presenting Manifestation of Multiple Myeloma.", The American Journal of dermatopathology, 2021. Abstract

ABSTRACT: Crystalglobulinemia (CG) is a rare disorder characterized by crystallization of monoclonal immunoglobulins in the microcirculation leading to multiorgan vascular thrombosis and ischemic injury. The main cause of CG is multiple myeloma. We report a case of a 52-year-old man who presented with widespread necrotizing plaques and ulcerations. A skin biopsy revealed eosinophilic rectangular-shaped crystals occluding the lumina of blood vessels with no associated features of vasculitis. The crystals were Periodic acid-Schiff stain positive. The findings were diagnostic of CG. Extensive work up lead to the discovery of multiple myeloma. Awareness of CG is important because it may be the first presenting manifestation of an underlying serious hematological malignancy.

Abdel-Halim, M. R. E., A. Mahmoud, and G. Ragab, "Cutaneous manifestations of ANCA associated vasculitis", Vessel Plus, vol. 6, 2022.
Hoshy, K. E., M. R. E. Abdel-Halim, E. El-Nabarawy, and S. Shalaby, "Cutaneous Protothecosis as an Unusual Complication Following Dermal Filler Injection: A Case Report.", The Journal of clinical and aesthetic dermatology, vol. 12, issue 12, pp. 13-16, 2019. Abstract

A 77-year-old female patient presented with bilateral tender, swollen, erythematous, focally crusted cheeks with a discharge of pus and necrotic material, which had developed one month after autologous fat transfer and a corrective injection procedure conducted to correct an overdone fat transfer. Histopathological examination of the discharged material using routine hematoxylin and eosin staining revealed degenerated collagen admixed with three different filler materials. Scattered all throughout the specimen were numerous thick-walled, basophilic, nonbudding spherical bodies of variable sizes. The bodies stained positively with Periodic acid-Schiff and Alcian blue and showed internal septation and sporangia with a morula-like appearance. The morphology of these bodies was characteristic of a infection. The patient was treated by surgical drainage accompanied by itraconazole 200mg daily for six months, ultimately showing marked improvement.

Elbendary, A., H. A. Abdelkader, Y. Abdel-Galeil, M. El-Mofty, A. M. Sultan, A. S. Elkomi, and M. R. E. Abdel-Halim, "Cytoplasmic CD3 Positivity as the Only Clue for the Diagnosis of T-Acute Lymphoblastic Leukemia With Cutaneous Deposits: A Case Report.", The American Journal of dermatopathology, vol. 42(1), pp. 43-45, 2020.
Mostafa, N. A., M. Assaf, S. Elhakim, M. R. E. Abdel-Halim, E. El-Nabarawy, and khaled Gharib, "Diagnostic accuracy of immunohistochemical markers in differentiation between basal cell carcinoma and trichoepithelioma in small biopsy specimens.", Journal of cutaneous pathology, vol. 45, issue 11, pp. 807-816, 2018 Nov. Abstract

BACKGROUND: The distinction of trichoepithelioma from basal cell carcinoma in small superficial biopsies is important but often challenging. This has inspired many scientists to test the validity of immunohistochemical markers in the differential diagnosis.

OBJECTIVES: To develop an immunohistochemical protocol that helps in differentiation between both trichoepithelioma (TE) and basal cell carcinoma (BCC) with higher sensitivity and specificity.

METHODS: Using standard immunohistochemical techniques, we examined 10 TEs and 19 BCCs for the expression of CK19, Ki-67, androgen receptors (AR), CD10, and PHLDA1.

RESULTS: Immunoreactivity of AR, Ki-67, and CD10 in tumor cells was significantly higher in BCC than TE with a diagnostic accuracy in BCC of 75.5%, 75.8%, and 79.3% respectively, whereas immunoreactivity of PHLDA1 in tumor cells and stromal CD10 was significantly higher in TE than BCC with a diagnostic accuracy in TE of 100% and 82.8%, respectively. In contrast, immunoreactivity for CK19 showed no statistically significant differences between both tumors.

CONCLUSION: The analysis of CD10, Ki-67, and PHLDA1 can be used as a helpful immunohistochemical panel in the distinction between TE and BCC especially in small and superficial biopsies.

Enany, G. E., H. Nada, N. Nagui, I. Sany, A. Nada, S. Ibrahim, O. EGhannam, and M. R. E. Abdel-Halim, Diffuse cicatricial alopecia and multiple telangiectatic indurated leg plaques, , 2020.
Esmat, S., M. R. E. Abdel-Halim, A. El-Tawdy, M. M. Fawzy, A. Ragheb, and N. Hasan, "Does increasing the pulse duration increase the efficacy of long pulsed Nd: YAG laser assisted hair removal? A split-chin clinical trial", European Journal of Dermatology, vol. 1, no. 1, pp. 0–0, 2014. Abstract
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Abdelkader, H. A., M. M. Fawzy, N. Nour, and M. R. E. Abdel-Halim, "Eczematous mucinous eccrine nevus: a novel presentation with Meyerson phenomenon.", International journal of dermatology, 2022.
Youssef, R., M. R. E. Abdel-Halim, M. Kamel, M. Khorshid, and A. Fahim, "Effect of polymorphisms in IL-12B p40, IL-17A and IL-23 A/G genes on the response of psoriatic patients to narrowband UVB.", Photodermatology, photoimmunology & photomedicine, vol. 34, issue 5, pp. 347-349, 2018 09.
Ragab, M. S., S. M. Essmat, D. A. Bassiounv, M. R. E. Abdel-Halim, H. H. El-Hadidi, N. M. El-Sharkawy, F. M. Ghaleb, and S. M. Al-Maghrabi, Effect of staphylococcal colonization and exotoxin production on apoptosis in atopic dermatitis, , 2005. Abstract

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Elsayed, H., S. SHALABY, M. R. E. Abdel-Halim, D. M. Aboelfadl, and N. Samir, "Efficacy of doxycycline in the treatment of early stages of mycosis fungoides: a randomized controlled trial.", The Journal of dermatological treatment, pp. 1-8, 2019. Abstract

Mycosis fungoides is the most common type of primary cutaneous T cell lymphomas. Doxycycline promoted apoptosis in different human malignant cell lines and in vivo models. To test for the therapeutic efficacy of doxycycline in comparison to PUVA in early stages of classic MF and its effect on T cell apoptosis. Thirty-six patients were randomized into either: doxycycline 200 mg daily ( = 18) or PUVA (3 weekly sessions) ( = 18) for 12 weeks. The primary outcome (therapeutic efficacy) was defined in terms of objective response rate (ORR) which was measured according to changes in the modified severity weighted assessment tool (mSWAT). Doxycycline achieved significantly less ORR (partial response) in comparison to PUVA (11.1%, 50%, respectively,  = .016). The percent reduction in mSWAT, CAILS, histopathology score and CD3 expression was significantly less in the doxycycline group ( = .001,  = .001,  ˂ .001, and  = .004, respectively). Within the doxycycline group, changes in mSWAT and CAILS showed no correlation with changes in the CD3 or Bcl-2 expression. Gastric upset was significantly more encountered in the doxycycline group ( = .001). Doxycycline is not suitable as a sole agent in the treatment of early stages of classic MF, acting mainly by anti-inflammatory rather apoptotic function. NCT03454945 ( www.clinicaltrials.gov ).