@article {250698,
	title = {Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF-κB and caspase-3 activities.},
	journal = {Environmental science and pollution research international},
	volume = {30},
	year = {2023},
	pages = {17657-17669},
	abstract = {<p>5-Fluorouracil (5-FU) is a chemotherapy used to treat many types of cancer. Cardiotoxicity is one of the common drawbacks of 5-FU therapy. Quercetin (Qu) is a bioflavonoid with striking biological activities. This research aimed to assess the ameliorative effect of Qu against 5-FU-mediated cardiotoxicity. Thirty-five rats were allocated into five groups: control group (normal saline), 5-FU group (30 mg/kg, intraperitoneally), Qu group (50 mg/kg, oral), 25 mg/kg Qu+5-FU group, and 50 mg/kg Qu+5-FU. The experimental animals were received the above-mentioned drugs for 21 days. Results showed that 5-FU significantly elevated creatine kinase, lactate dehydrogenase, serum cholesterol and triglyceride, and upregulated troponin and renin mRNA expression. Additionally, cardiac oxidant/antioxidant imbalance was evident in elevated oxidants (malondialdehyde and nitric oxide) and depleted antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione). 5-FU also downregulated the gene expression of nuclear factor erythroid 2-related factor 2. Furthermore, 5-FU significantly increased cardiac pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1 beta) and upregulated gene expression of nuclear factor kappa-B. 5-FU significantly enhanced cardiac apoptosis through upregulating caspase-3 expression and downregulating B-cell lymphoma 2. Immunohistochemical and histopathological examinations verified the above-mentioned findings. However, all these changes were significantly ameliorated in Qu pre-administered rats. Conclusively, Qu counteracted 5-FU-mediated cardiotoxicity through potent antioxidant, anti-inflammatory, and anti-apoptotic effects.</p>
},
	attachments = {https://scholar.cu.edu.eg/sites/default/files/mohdhefny/files/protective_effect_of_quercetin_against_5-fluorouracil-induced_cardiac_impairments_through_activating_nrf2_and_inhibiting_nf-kb_and_caspase-3_activities_0.pdf},
	author = {Lokman, Maha S and Althagafi, Hussam A and Alharthi, Fahad and Ola A. Habotta and Arwa A. Hassan and Mohamed A. Elhefny and Al Sberi, Hassan and Theyab, Abdulrahman and Mufti, Ahmad Hasan and Alhazmi, Alaa and Hawsawi, Yousef M and Asmaa F. Khafaga and Mahmoud S Gewaily and Khalaf F Alsharif and Ashraf Albrakati and Rami B. Kassab}
}
