Farag, M. M., W. El-Sebaie, E. B. Basalious, and O. N. El-Gazayerly, Self-Nanoemulsifying/ Self-Assembled Cubic Nanoparticles Lyophilized Tablet: A Novel Biphasic Release Approach to Enhance the Bioavailability of a Lipophilic Drug, , vol. 25, issue 8, pp. 250, 2024. AbstractWebsite

This study aimed to prepare a combined self-nanoemulsifying and self-assembled cubic nanoparticles (SNE/SAC) lyophilized tablet eliciting biphasic release pattern escorted with enhanced bioavailability for drugs hampered with slow dissolution and poor absorption. The antimuscarinic Darifenacin hydrobromide (DRF) was selected as a model drug used to treat overactive bladder-associated nocturia. The DRF-SNE/SAC lyophilized tablet was prepared so that upon reconstitution a mixture of DRF-loaded cubic nanoparticles and nanoemulsion dispersion is obtained. The nanoemulsion portion is responsible for the fast release followed by controlled release of the remaining dose loaded in cubic nanoparticles. A comparative pharmacokinetic study adopting randomized crossover design in male albino rabbits versus marketed product Frequefenacine® tablet was performed. Half of the dose (52.05% ± 4.21%) was rapidly released in the first 4 h followed by sustained release of the remaining drug where (90.16% ± 8.85%) was released in 24 h. The tested system showed 2.45 folds higher % relative bioavailability and 1.57 folds higher Cmax with 1.62 longer residence time relative to reference product. The results endow the ability of the developed DRF-SNE/SAC lyophilized tablet to be considered as a propitious approach for the treatment of overactive bladder-associated nocturia without midnight dose administration.

Ahmed, S., M. M. Farag, M. A. Sadek, and D. E. Aziz, "Transdermal application of diacerin loaded-terpene enriched invasomes: an approach to augment anti-edema and nociception inhibition activity", Journal of Liposome Research: Taylor & Francis, pp. 1-14, 2024. Abstract
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Ali, M. M., A. K. Al-Mokaddem, E. Abdel-Sattar, R. A. El-Shiekh, M. M. Farag, S. H. Aljuaydi, and I. B. Shaheed, "Enhanced wound healing potential of arabincoside B isolated from Caralluma Arabica in rat model; a possible dressing in veterinary practice", BMC Veterinary Research, vol. 20, issue 1: Springer, pp. 282, 2024. Abstract
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Eltaweel, M. M., M. A. Tawfik, K. Soliman, M. S. Khattab, and M. M. Farag, "Tailoring of topically applied curcumin loaded pro-novasomes for skin cancer treatment: In-vitro characterization, statistical optimization and histopathological assessment of subcutaneous Ehrlich carcinoma mice model", Journal of Drug Delivery Science and Technology, vol. 88: Elsevier, pp. 104957, 2023. Abstract
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Tawfik, M. A., M. M. Eltaweel, M. M. Farag, H. A. Shamsel-Din, and ahmed b ibrahim, "Sonophoresis-assisted transdermal delivery of antimigraine-loaded nanolipomers: Radio-tracking, histopathological assessment and in-vivo biodistribution study", International Journal of Pharmaceutics, vol. 644: Elsevier, pp. 123338, 2023. Abstract
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Farag, M. M., H. B. El-Nassan, H. A. Merey, B. M. Eltanany, M. M. Galal, W. Wadie, D. M. El-Tanbouly, M. A. Khattab, L. A. Rashed, and A. N. ElMeshad, "Comparative pharmacodynamic study delineating the efficacy of amantadine loaded nano-emulsified organogel via intranasal versus transdermal route in rotenone-induced Parkinson's disease rat model", Journal of Drug Delivery Science and Technology, vol. 86: Elsevier, pp. 104765, 2023. Abstract
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Farag, M. M., W. El-Sebaie, E. B. Basalious, and O. N. El-Gazayerly, "Darifenacin Self-assembled Liquid Crystal Cubic Nanoparticles: a Sustained Release Approach for an Overnight Control of Overactive Bladder", AAPS PharmSciTech, vol. 24, issue 5: Springer, pp. 120, 2023. Abstract
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Farag, M. M., M. M. Louis, A. A. Badawy, D. I. Nessem, and N. A. S. ElMalak, "Drotaverine Hydrochloride Superporous Hydrogel Hybrid System: a gastroretentive approach for sustained drug delivery and enhanced viscoelasticity.", AAPS PharmSciTech, vol. 23, issue 5, pp. 1-12, 2022.
Farag, M. M., N. E. V. I. N. E. S. ABDELMALAK, S. A. Yehia, and M. A. Ahmed, "Hyaluronic Acid Conjugated Metformin-Phospholipid Sonocomplex: A Biphasic Complexation Approach to Correct Hypoxic Tumour Microenvironment", International Journal of Nanomedicine, vol. 16: Dove Press, pp. 1005, 2021. Abstract
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Farag, M. M., N. E. V. I. N. E. S. ABDELMALAK, S. A. Yehia, and M. A. Ahmed, "Sonocomplexation as an effective tool to enhance the antitumorigenic effect of metformin: Preparation, in vitro characterization, molecular dynamic simulation & MiaPaCa-2 cell line hypoxia evaluation", Journal of Drug Delivery Science and Technology, vol. 59: Elsevier, pp. 101968, 2020. Abstract

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