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Proc. Symp. Wakan-Yaku Proc. Symp. Wakan-Yaku 10, 103-108, 1999, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Proc. Symp. Wakan-Yaku, Volume 10, p.103-108, (1999) Abstract
Preparation of Lignan-Rich Extract from the Aerial Parts of Using Nonconventional Methods., Meselhy, Meselhy R., Abdel-Sattar Ola E., El-Mekkawy Sahar, El-Desoky Ahmed M., Mohamed Shanaz O., Mohsen Sobhy M., Abdel-Sattar Essam, and Halawany Ali El- , Molecules (Basel, Switzerland), Volume 25, Issue 5, (2020) Abstract

Phyllanthin and related lignans were found to be responsible, at least in part, for most of the activity of species. This observation encouraged the authors to develop methods for the preparation of an extract rich in phyllanthin and related lignans from the aerial parts of L. Direct extraction with solvents produced extracts with variable yields and contents of lignans. Lignans were identified by LC-ESI-MS analysis as phyllanthin (used as marker substance), hypophyllanthin, phylltetralin, nirtetralin, and niranthin. Extraction with boiling water produced 18.10 g% (/) extract with a trace amount of lignans (phyllanthin content of 0.33 ± 0.10 mg/g extract), while extraction with MeOH gave 3.6 g% / extract with a low phyllanthin content (3.1 mg/g extract), as determined by HPLC. However, Soxhlet extraction with hexane, CHCl, or acetone gave extracts with low yields (0.82, 1.12, and 3.40 g% /, respectively) and a higher phyllanthin contents (36.2 ± 2.6, 11.7 ± 1.68, and 11.7 ± 1.10 mg/g extract, respectively). Extraction quality and efficiency were optimized by adopting the following three different approaches: (1) Alkaline digestion of the plant material with 30% potassium hydroxide yielded 3.1 g% / of purified extract with high phyllanthin content (22.34 ± 0.13 mg/g); (2) microwave-assisted extraction using 80% MeOH gave an extract with a better yield (8.13 g% /) and phyllanthin content (21.2 ± 1.30 mg/g) (after filtration through a Diaion HP-20 column); and (3) treatment of the ground plant material at 50 °C with two hydrolytic enzymes, cellulase (9 U/g for 12 h) and then, protease (4 U/g up to 72 h) optimized the yield of extract (13.92 g% /) and phyllanthin content (25.9 mg/g extract and total lignans content of 85.87 mg/g extract). In conclusion, the nonconventional methods presented here are superior for optimizing the yield of extract and its lignan contents from the aerial parts of .

Potent anticonvulsant paeonimetabolin-I derivatives obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MOHAMED Tarek A., MAHFOUZ Nadia M., and EL-GENDY Mahmoud A. , Chemical and pharmaceutical bulletin, Volume 46, Issue 9, p.1486-1487, (1998) Abstract
Polyphenols LC-MS2 profile of Ajwa date fruit (Phoenix dactylifera L.) and their microemulsion: Potential impact on hepatic fibrosis, Nematallah, Khaled A., Ayoub Nahla A., Abdelsattar Essam, Meselhy Meselhy R., Elmazar Mohey M., El-Khatib Ahmed H., Linscheid Michael W., Hathout Rania M., Godugu Kavitha, and Adel Aya , Journal of Functional Foods, Volume 49, p.401-411, (2018) Abstract
Phenolics from Maytenus senegalensis, Hussein, Ghazi, Nakamura Norio, Meselhy Meselhy R., and Hattori Masao , Phytochemistry, Volume 50, Issue 4, p.689-694, (1999) Abstract
Phenolic constituents from Grevillea robusta, Ahmed, Amany S., Nakamura Norio, Meselhy Meselhy R., Makhboul Makhboul A., El-Emary Nasr, and Hattori Masao , Phytochemistry, Volume 53, Issue 1, p.149-154, (2000) Abstract
Pharmacokinetic study of paeoniflorin, paeonimetabolin-I and glycyrrhetic acid in humans after oral administration of paeony root, Glycyrrhiza and Shakuyaku-kanzo-to (Shao-Yao-Gan-Cao-Tang)., Bando, Miyuki, Shibahara Naotoshi, Shimada Yutaka, Meselhy Meselhy R., Akao Teruaki, Itoh Takashi, and Terasawa Katsutoshi , Journal of Traditional Medicines, Volume 17, Issue 1, p.26-33, (2000) Abstract