Publications

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1
12-O-acetylphorbol-13-decanoate potently inhibits cytopathic effects of human immunodeficiency virus type 1 (HIV-1), without activation of protein kinase C, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , CHEMICAL AND PHARMACEUTICAL BULLETIN-TOKYO-, Volume 47, p.1346-1347, (1999) Abstract
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A
Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Tezuka Yasuhiro, Hattori Masao, Kakiuchi Nobuko, Shimotohno Kunitada, Kawahata Takuya, and Otake Toru , Phytochemistry, Volume 49, Issue 6, p.1651-1657, (1998) Abstract
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Anti-HIV-1 phorbol esters from the seeds of Croton tiglium, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Phytochemistry, Volume 53, Issue 4, p.457-464, (2000) Abstract
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Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MURAKAMI Yukihisa, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Biological and Pharmaceutical Bulletin, Volume 22, Issue 5, p.491-497, (1999) Abstract
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B
Biotransformation of (-)-epicatechin 3-O-gallate by human intestinal bacteria, Meselhy, Meselhy R., Nakamura Norio, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 45, Issue 5, p.888-893, (1997) Abstract
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Biotransformation of a C-Glycosylflavone, Abrusin 2"-O-β-D-Apioside, by Human Intestinal Bacteria, Li, Yan, Meselhy Meselhy R., Wang Li-Quan, Nakamura Norio, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 48, Issue 8, p.1239-1241, (2000) Abstract
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Biotransformation of shikonin by human intestinal bacteria, Meselhy, Meselhy R., KADOTA Shigetoshi, Tsubono Koji, Hattori Masao, and NAMBA Tsuneo , Tetrahedron, Volume 50, Issue 10, p.3081-3098, (1994) Abstract
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C
Comparative study of chemical constituents of rhubarb from different origins, Komatsu, Katsuko, Nagayama Yorinobu, Tanaka Ken, Ling Yun, Cai Shao-Qing, Omote Takayuki, and Meselhy Meselhy Ragab , Chemical and pharmaceutical bulletin, Volume 54, Issue 11, p.1491-1499, (2006) Abstract
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Conversion of aconitine to lipoaconitine by human intestinal bacteria and their antinociceptive effects in mice, Kawata, Yukio, Cho-mei MA, Nakamura Norio, WANG Hong, NAMBA Tsuneo, SATOH Kazuya, and KURAISHI Yasushi , 和漢医薬学雑誌= Journal of traditional medicines, Volume 16, Issue 1, p.15-23, (1999) Abstract
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Dammarane-type triterpenes from Cordia spinescens, Nakamura, Norio, Kojima Shiho, Lim Yasmina Aura, Meselhy Meselhy R., Hattori Masao, Gupta Mahabir P., and Correa Mireya , Phytochemistry, Volume 46, Issue 6, p.1139-1141, (1997) Abstract
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Developing of anti-HIV agents from natural resources (Chemical & Pharmacological study), Meselhy, Meselhy Ragab, El-Mekkawy Sahar, Ma Chaomei, Nakamura Norio, TEWTRAKUL Supinya, and Hattori Masao , 和漢医薬学雑誌, Volume 22, Issue 1, p.116-128, (2005) Abstract
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Development of a high performance liquid chromatographic method for systematic quantitative analysis of chemical constituents in rhubarb, Komatsu, Katsuko, Nagayama Yorinobu, Tanaka Ken, Ling Yun, Basnet Purusotam, and Meselhy Meselhy Ragab , Chemical and pharmaceutical bulletin, Volume 54, Issue 7, p.941-947, (2006) Abstract
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Diterpene acids from Conyza incana, Galal, Ahmed M., Abdel-Sattar Essam, El-Feraly Farouk S., Mossa Jaber S., Meselhy Meselhy R., KADOTA Shigetoshi, and NAMBA Tsuneo , Phytochemistry, Volume 48, Issue 1, p.159-163, (1998) Abstract
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E
Effect of tinctormine on contraction and Ca2+ currents in single cardiac myocytes from dog, Meselhy, M. R., Momose Y., Hatakeyama N., Kadota S., Hattori M., and Namba T. , Phytomedicine, Volume 1, Issue 4, p.277-281, (1995) Abstract
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Effects of paeoniflorin derivatives on scopolamine-induced amnesia using a passive avoidance task in mice; structure-activity relationship, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MUKARAMI Yukihisa, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Biological and Pharmaceutical Bulletin, Volume 21, Issue 11, p.1174-1179, (1998) Abstract
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Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum, GAO, Jiang Jing, MIN Byung Sun, Akao Teruaki, Meselhy Meselhy R., and Nakamura Norio , 和漢医薬学雑誌, Volume 18, Issue 4, p.154-160, (2001) Abstract
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Four mono-tetrahydrofuran ring acetogenins, montanacins BE, from Annona montana, Wang, Li-Quan, Nakamura Norio, Meselhy Meselhy R., Hattori Masao, ZHAO Wei-Min, CHENG Kin-Fai, YANG Ren-Zhou, and QIN Guo-Wei , Chemical and pharmaceutical bulletin, Volume 48, Issue 8, p.1109-1113, (2000) Abstract
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Guaianolides from Centaurea scoparia, Helal, Amr M., Nakamura Norio, Meselhy Meselhy R., El-Fishawy Ahlam M., Hattori Masao, and Mahran Gamal H. , Phytochemistry, Volume 45, Issue 3, p.551-554, (1997) Abstract
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The heterocyclic ring fission and dehydroxylation of catechins and related compounds by Eubacterium sp. strain SDG-2, a human intestinal bacterium, Wang, Li-Quan, Meselhy Meselhy Ragab, Li Yan, Nakamura Norio, MIN Byung-Sun, QIN Guo-Wei, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 49, Issue 12, p.1640-1643, (2001) Abstract
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Human intestinal Bacteroides spp. RHEIN-I and RHEIN-II capable of transforming rhein to rheinanthrone, induce rhein-dependent diarrhea in rats, Meselhy, Meselhy Ragab, Nishimoto Eri, Akao Teruaki, and Hattori Masao , J Trad Med, Volume 18, Issue 4, p.169-176, (2001) Abstract
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I
In vivo Antiviral Activity of Stephania cepharantha against Herpes Simplex Virus Type‐1, ari Nawawi, As', Nakamura Norio, Meselhy Meselhy R., Hattori Masao, Kurokawa Masahiko, Shiraki Kimiyasu, Kashiwaba Noriaki, and Ono Minoru , Phytotherapy research, Volume 15, Issue 6, p.497-500, (2001) Abstract
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Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives, El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Chemical and pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002) Abstract
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Inhibitory effects of egyptian folk medicines oh human immunodeficiency virus (HIV) reverse transcriptase, El-Mekkawy, Sahar, Meselhy Meselhy R., KUSUMOTO Ines Tomoco, KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Chemical and Pharmaceutical Bulletin, Volume 43, Issue 4, p.641-648, (1995) Abstract
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M
Metabolism of safflor yellow B by human intestinal bacteria, Meselhy, M. R., KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Journal of natural products, Volume 56, Issue 1, p.39-45, (1993) Abstract
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Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria, El-Mekkawy, Sahar, Meselhy M. R., Kawata Yukio, KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Planta medica, Volume 59, Issue 04, p.347-350, (1993) Abstract
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N
Natural Products as Antiviral Agents Natural Products as Antiviral Agents, 1-29, 1992, El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Chemical & pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002) Abstract
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A new enzyme immunoassay for aconitine and its application to quantitative determination of aconitine levels in plasma, Tazawa, Takako, Zhao Huai-qing, Li Yan, Meselhy Meselhy Ragab, Nakamura Norio, Akao Teruaki, and Hattori Masao , Biological and Pharmaceutical Bulletin, Volume 26, Issue 9, p.1289-1294, (2003) Abstract
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New paeonilactone-A adducts formed by anaerobic incubation of paeoniflorin with Lactobacillus brevis in the presence of arylthiols, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Chemical and pharmaceutical bulletin, Volume 49, Issue 7, p.918-920, (2001) Abstract
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P
Phenolic constituents from Grevillea robusta, Ahmed, Amany S., Nakamura Norio, Meselhy Meselhy R., Makhboul Makhboul A., El-Emary Nasr, and Hattori Masao , Phytochemistry, Volume 53, Issue 1, p.149-154, (2000) Abstract
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Phenolics from Maytenus senegalensis, Hussein, Ghazi, Nakamura Norio, Meselhy Meselhy R., and Hattori Masao , Phytochemistry, Volume 50, Issue 4, p.689-694, (1999) Abstract
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Polyphenols LC-MS2 profile of Ajwa date fruit (Phoenix dactylifera L.) and their microemulsion: Potential impact on hepatic fibrosis, Nematallah, Khaled A., Ayoub Nahla A., Abdelsattar Essam, Meselhy Meselhy R., Elmazar Mohey M., El-Khatib Ahmed H., Linscheid Michael W., Hathout Rania M., Godugu Kavitha, and Adel Aya , Journal of Functional Foods, Volume 49, p.401-411, (2018) Abstract
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Potent anticonvulsant paeonimetabolin-I derivatives obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MOHAMED Tarek A., MAHFOUZ Nadia M., and EL-GENDY Mahmoud A. , Chemical and pharmaceutical bulletin, Volume 46, Issue 9, p.1486-1487, (1998) Abstract
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Shikometabolins A, B, C and D, novel dimeric naphthoquinone metabolites obtained from shikonin by human intestinal bacteria, Meselhy, Meselhy R., KADOTA Shigetoshi, Tsubono Koji, KUSAI Akihiko, Hattori Masao, and NAMBA Tsuneo , Tetrahedron letters, Volume 35, Issue 4, p.583-586, (1994) Abstract
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Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii, El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita , Natural product research, Volume 27, Issue 2, p.146-154, (2013) Abstract
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Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii., El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita , Natural product research, 2013, Volume 27, Issue 2, p.146-54, (2013) Abstract

Three new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangambin, gugglsterol I, (E)-guggulsterone and (Z)-guggulsterone. Their structures were elucidated on the basis of different spectroscopic data. α-Glucosidase inhibitory effects of HSF and the isolated compounds were evaluated calorimetrically. The HSF showed significant α-glucosidase inhibitory effect [IC(50) value of 140 µg mL(-1) (p < 0.05)]. Under the assay conditions, diasesartemin (IC(50) = 60.6 ± 0.01 µM) was found to be more potent than the positive control, acarbose (IC(50) = 92.94 ± 0.01 µM); a known α-glucosidase inhibitor (p < 0.05). The IC(50) values of epi-mukulin and (Z)-guggulsterone were found to be 159.33 and 132.14 µM, respectively. Other compounds showed weak α-glucosidase inhibitory effects, <30% inhibition of the enzyme activity at 0.1 mg mL(-1).

TINCTRMINE, A NOVEL Ca2+ ANTAGONIST N-CONTAINING QUINOCHALCONE C-GLYCOSIDE FROM CARTHAMUS TINCTORIUS L., Meselhy, Meselhy R., KADOTA Shigetoshi, Momose Yasunori, Hattori Masao, and NAMBA Tsuneo , Chemical and pharmaceutical bulletin, Volume 40, Issue 12, p.3355-3357, (1992) Abstract
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Transformation of shikonin by a cell-free extract of Eubacterium sp. A-44, a human intestinal bacterium, Meselhy, Meselhy R., Nishimoto Eri, Akao Teruaki, and Hattori Masao , (2001) Abstract
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Two new quinochalcone yellow pigments from Carthamus tinctorius and Ca2+ antagonistic activity of tinctormine, Meselhy, Meselhy R., KADOTA Shigetoshi, Momose Yasunori, HATAKEYAMA Noboru, KUSAI Akihiko, Hattori Masao, and NAMBA Tsuneo , Chemical and pharmaceutical bulletin, Volume 41, Issue 10, p.1796-1802, (1993) Abstract
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和漢医薬学雑誌= Journal of traditional medicines 20 (5), 201-207, 2003-10-20, Xiong, Xin, Zhai Suodi, Yao Zhongqiang, Tazawa Takako, Zhao Huai-qing, Li Yan, Meselhy Meselhy Ragab, Nakamura Norio, Akao Teruaki, and Hattori Masao , Prog. Neurobiol, Volume 56, p.211-235, (1998) Abstract
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Tourism