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Two new quinochalcone yellow pigments from Carthamus tinctorius and Ca2+ antagonistic activity of tinctormine, Meselhy, Meselhy R., KADOTA Shigetoshi, Momose Yasunori, HATAKEYAMA Noboru, KUSAI Akihiko, Hattori Masao, and NAMBA Tsuneo , Chemical and pharmaceutical bulletin, Volume 41, Issue 10, p.1796-1802, (1993) Abstract
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TINCTRMINE, A NOVEL Ca2+ ANTAGONIST N-CONTAINING QUINOCHALCONE C-GLYCOSIDE FROM CARTHAMUS TINCTORIUS L., Meselhy, Meselhy R., KADOTA Shigetoshi, Momose Yasunori, Hattori Masao, and NAMBA Tsuneo , Chemical and pharmaceutical bulletin, Volume 40, Issue 12, p.3355-3357, (1992) Abstract
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Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells., Abdellatef, Amira A., Zhou Yue, Yamada Akane, Elmekkawy Sahar A., Kohyama Aki, Yokoyama Satoru, Meselhy Meselhy R., Matsuya Yuji, Sakurai Hiroaki, and Hayakawa Yoshihiro , Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Volume 140, p.111737, (2021) Abstract

Guggulsterone (GS) [4,17(20)-pregnadiene-3,16-dione], is the main active phytosterol constituent in guggul, the gum resin of Commiphora wightii (Arnott.) Bhand./Commiphora mukul Engl. tree, and is known for its medicinal effects. In this study, we report that GSD-1, a structurally-related synthetic GS derivative, strongly inhibits NF-κB activation induced by TNF-α. GSD-1 prevented the nuclear translocation of p65 through the blockade of IκBα degradation and p65 phosphorylation, and further inhibited the activation of upstream kinases, including transforming growth factor-β activated kinase 1 (TAK1), IκB kinase (IKK) α, and IKKβ. Furthermore, GSD-1 inhibited the cell-intrinsic activation of NF-κB, and exerted its direct anti-cancer and anti-metastatic effects in both murine and human breast cancer cell lines. This study demonstrated GSD-1 to be an attractive compound to target NF-κB activation that has potential for treating breast cancer growth and metastasis.

Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells., Kohyama, Aki, Yokoyama Rei, Dibwe Dya Fita, El-Mekkawy Sahar, Meselhy Meselhy R., Awale Suresh, and Matsuya Yuji , Bioorganic & medicinal chemistry letters, Volume 30, Issue 7, p.126964, (2020) Abstract

E- and Z-guggulsterones and nine guggulsterone derivatives (GSDs) were synthesized and evaluated for their preferential cytotoxicity against human PANC-1 cell in nutrient deprived medium utilizing antiausterity strategy. Among the synthesized compounds, GSD-1 and GSD-7 showed potent cytotoxicity against PANC-1 cells under nutrient-deprived conditions in a concentration dependent manner, with a PC value of 1.6 μM and 3.2 μM, respectively. The effect of GSD-1 and GSD-7 was further evaluated in a real time using live cell imaging. Both of these compounds altered PANC-1 cell morphology, leading to cell death at sub micromolar concentration range. GSD-1 and GSD-7 also inhibited PANC-1 cell colony formation in a concentration-dependent manner. GSD-1 and GSD-7 are lead structure for the anti-austerity drug development.

Simultaneous determination of triterpene saponins in ginseng drugs by high-performance liquid chromatography, Zhu, Shu, Zou Kun, Cai Shaoqing, Meselhy Meselhy Ragab, and Komatsu Katsuko , Chemical and pharmaceutical bulletin, Volume 52, Issue 8, p.995-998, (2004) Abstract
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Shikometabolins A, B, C and D, novel dimeric naphthoquinone metabolites obtained from shikonin by human intestinal bacteria, Meselhy, Meselhy R., KADOTA Shigetoshi, Tsubono Koji, KUSAI Akihiko, Hattori Masao, and NAMBA Tsuneo , Tetrahedron letters, Volume 35, Issue 4, p.583-586, (1994) Abstract
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Proc. Symp. Wakan-Yaku Proc. Symp. Wakan-Yaku 10, 103-108, 1999, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Proc. Symp. Wakan-Yaku, Volume 10, p.103-108, (1999) Abstract
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Natural Products as Antiviral Agents Natural Products as Antiviral Agents, 1-29, 1992, El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Chemical & pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002) Abstract
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Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria, El-Mekkawy, Sahar, Meselhy M. R., Kawata Yukio, KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Planta medica, Volume 59, Issue 04, p.347-350, (1993) Abstract
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Metabolism of safflor yellow B by human intestinal bacteria, Meselhy, M. R., KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Journal of natural products, Volume 56, Issue 1, p.39-45, (1993) Abstract
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Metabolism and pharmacokinetics of orally administered saikosaponin b1 in conventional, germ-free and Eubacterium sp. A-44-infected gnotobiote rats, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Biological and Pharmaceutical Bulletin, Volume 21, Issue 6, p.588-593, (1998) Abstract
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Intestinal injury can be effectively prevented by in gamma irradiated rats., Khayyal, Mohamed T., El-Baz Farouk K., Meselhy Meselhy R., Ali Gamila H., and El-Hazek Rania M. , Heliyon, Volume 5, Issue 5, p.e01814, (2019) Abstract

is one of the most common microalgae that is used as human food. It is isolated from the salty lakes in El-Fayoum and Lake of Bardawil-Sinai in Egypt and can withstand very high concentrations of salt: The potentiality of , a unicellular biflagellate green alga to protect against intestinal injury induced after radiation exposure was studied. was given orally in doses of 100 and 200 mg/kg to male Wistar rats for 5 days before exposure to 6 Gray (Gy) gamma radiation and continued for a further two days. Rats were sacrificed 24 h later and intestinal segments were dissected out. One segment was examined histologically and another was used to prepare homogenates to assess relevant biochemical parameters reflecting intestinal injury. Radiation exposure led to a rise in the histological damage score, an increase in tissue tumor necrosis factor (TNF-α), interleukin (IL-1β) and thiobarbituric acid reactive substances (TBARS) but a reduction in tissue reduced glutathione (GSH) and in serum citrulline. Pretreatment with either dose of effectively reduced the severity of intestinal mucositis induced by gamma radiation.

Inhibitory effects of egyptian folk medicines oh human immunodeficiency virus (HIV) reverse transcriptase, El-Mekkawy, Sahar, Meselhy Meselhy R., KUSUMOTO Ines Tomoco, KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Chemical and Pharmaceutical Bulletin, Volume 43, Issue 4, p.641-648, (1995) Abstract
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Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives, El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Chemical and pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002) Abstract
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In vivo Antiviral Activity of Stephania cepharantha against Herpes Simplex Virus Type‐1, ari Nawawi, As', Nakamura Norio, Meselhy Meselhy R., Hattori Masao, Kurokawa Masahiko, Shiraki Kimiyasu, Kashiwaba Noriaki, and Ono Minoru , Phytotherapy research, Volume 15, Issue 6, p.497-500, (2001) Abstract
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Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation, Basu, Nikhil K., Kubota Shigeki, Meselhy Meselhy R., Ciotti Marco, Chowdhury Bhabadeb, Hartori Masao, and Owens Ida S. , Journal of Biological Chemistry, Volume 279, Issue 27, p.28320-28329, (2004) Abstract
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Enzymes responsible for the metabolism of saikosaponins from Eubacterium sp. A-44, a human intestinal anaerobe, Kida, Hiroaki, Akao Teruaki, MESELHY Meselhy, and Hattori Masao , Biological and Pharmaceutical Bulletin, Volume 20, Issue 12, p.1274-1278, (1997) Abstract
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Effect of tinctormine on contraction and Ca2+ currents in single cardiac myocytes from dog, Meselhy, M. R., Momose Y., Hatakeyama N., Kadota S., Hattori M., and Namba T. , Phytomedicine, Volume 1, Issue 4, p.277-281, (1995) Abstract
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Diterpene acids from Conyza incana, Galal, Ahmed M., Abdel-Sattar Essam, El-Feraly Farouk S., Mossa Jaber S., Meselhy Meselhy R., KADOTA Shigetoshi, and NAMBA Tsuneo , Phytochemistry, Volume 48, Issue 1, p.159-163, (1998) Abstract
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Disposition of paeoniflorin and paeonimetabolin I in rats after oral administration of Toki-Shakuyaku-San (TS) and Shakuyaku-Kanzo-To (SK), Meselhy, Meselhy R., Heikal Ola A., Akao Teruaki, KHOJIMATOV OLIM, Hattori Masao, ONO HIROMASA, and SADAKANE CHIHARU , Natural medicines= 生薬學雜誌, Volume 52, Issue 3, p.265-268, (1998) Abstract
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Development of a high performance liquid chromatographic method for systematic quantitative analysis of chemical constituents in rhubarb, Komatsu, Katsuko, Nagayama Yorinobu, Tanaka Ken, Ling Yun, Basnet Purusotam, and Meselhy Meselhy Ragab , Chemical and pharmaceutical bulletin, Volume 54, Issue 7, p.941-947, (2006) Abstract
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Dammarane-type triterpenes from Cordia spinescens, Nakamura, Norio, Kojima Shiho, Lim Yasmina Aura, Meselhy Meselhy R., Hattori Masao, Gupta Mahabir P., and Correa Mireya , Phytochemistry, Volume 46, Issue 6, p.1139-1141, (1997) Abstract
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Dammarane-Type Saponins from Panax j aponicus and Their Neurite Outgrowth Activity in SK-N-SH Cells, Zou, Kun, Zhu Shu, Meselhy Meselhy R., Tohda Chihiro, Cai Shaoqing, and Komatsu Katsuko , Journal of natural products, Volume 65, Issue 9, p.1288-1292, (2002) Abstract
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Cytotoxicity of shikonin metabolites with biotransformation of human intestinal bacteria, MIN, Byung-Sun, Meselhy Meselhy-R, Hattori Masao, Kim Hwan-Mook, and Kim Young-Ho , Journal of microbiology and biotechnology, Volume 10, Issue 4, p.514-517, (2000) Abstract
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Conversion of aconitine to lipoaconitine by human intestinal bacteria and their antinociceptive effects in mice, Kawata, Yukio, Cho-mei MA, Nakamura Norio, WANG Hong, NAMBA Tsuneo, SATOH Kazuya, and KURAISHI Yasushi , 和漢医薬学雑誌= Journal of traditional medicines, Volume 16, Issue 1, p.15-23, (1999) Abstract
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Comparative study of chemical constituents of rhubarb from different origins, Komatsu, Katsuko, Nagayama Yorinobu, Tanaka Ken, Ling Yun, Cai Shao-Qing, Omote Takayuki, and Meselhy Meselhy Ragab , Chemical and pharmaceutical bulletin, Volume 54, Issue 11, p.1491-1499, (2006) Abstract
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Biotransformation of shikonin by human intestinal bacteria, Meselhy, Meselhy R., KADOTA Shigetoshi, Tsubono Koji, Hattori Masao, and NAMBA Tsuneo , Tetrahedron, Volume 50, Issue 10, p.3081-3098, (1994) Abstract
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Aβ (25–35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins, Tohda, Chihiro, Matsumoto Noriaki, Zou Kun, Meselhy Meselhy R., and Komatsu Katsuko , Neuropsychopharmacology, Volume 29, Issue 5, p.860, (2004) Abstract
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Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells, Tohda, Chihiro, Matsumoto Noriaki, Zou Kun, Meselhy Meselhy R., and Komatsu Katsuko , The Japanese Journal of Pharmacology, Volume 90, Issue 3, p.254-262, (2002) Abstract
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Anti-HIV-1 phorbol esters from the seeds of Croton tiglium, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Phytochemistry, Volume 53, Issue 4, p.457-464, (2000) Abstract
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Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Tezuka Yasuhiro, Hattori Masao, Kakiuchi Nobuko, Shimotohno Kunitada, Kawahata Takuya, and Otake Toru , Phytochemistry, Volume 49, Issue 6, p.1651-1657, (1998) Abstract
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12-O-acetylphorbol-13-decanoate potently inhibits cytopathic effects of human immunodeficiency virus type 1 (HIV-1), without activation of protein kinase C, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , CHEMICAL AND PHARMACEUTICAL BULLETIN-TOKYO-, Volume 47, p.1346-1347, (1999) Abstract
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The 117th Annual Meeting of the Pharmaceutical Society of Japan, Sendai, March The 117th Annual Meeting of the Pharmaceutical Society of Japan, Sendai, March 29, 1994, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Biological & pharmaceutical bulletin, Volume 21, Issue 6, p.588-593, (1998) Abstract
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Tourism