Comparative Antioxidant Activities of Selected Apiaceous Plants,
Emad, Ayat M., Ali Sherifa F., Meselhy Meselhy R., and Sattar Essam A.
, Pharmacognosy Journal, Volume 11, Issue 6, p.1-6, (2019)
Inhibitory effects of egyptian folk medicines oh human immunodeficiency virus (HIV) reverse transcriptase,
El-Mekkawy, Sahar, Meselhy Meselhy R., KUSUMOTO Ines Tomoco, KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo
, Chemical and Pharmaceutical Bulletin, Volume 43, Issue 4, p.641-648, (1995)
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Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives,
El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru
, Chemical and pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002)
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Anti-HIV-1 phorbol esters from the seeds of Croton tiglium,
El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru
, Phytochemistry, Volume 53, Issue 4, p.457-464, (2000)
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Natural Products as Antiviral Agents Natural Products as Antiviral Agents, 1-29, 1992,
El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru
, Chemical & pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002)
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Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria,
El-Mekkawy, Sahar, Meselhy M. R., Kawata Yukio, KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo
, Planta medica, Volume 59, Issue 04, p.347-350, (1993)
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12-O-acetylphorbol-13-decanoate potently inhibits cytopathic effects of human immunodeficiency virus type 1 (HIV-1), without activation of protein kinase C,
El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru
, CHEMICAL AND PHARMACEUTICAL BULLETIN-TOKYO-, Volume 47, p.1346-1347, (1999)
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Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii.,
El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita
, Natural product research, 2013, Volume 27, Issue 2, p.146-54, (2013)
AbstractThree new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangambin, gugglsterol I, (E)-guggulsterone and (Z)-guggulsterone. Their structures were elucidated on the basis of different spectroscopic data. α-Glucosidase inhibitory effects of HSF and the isolated compounds were evaluated calorimetrically. The HSF showed significant α-glucosidase inhibitory effect [IC(50) value of 140 µg mL(-1) (p < 0.05)]. Under the assay conditions, diasesartemin (IC(50) = 60.6 ± 0.01 µM) was found to be more potent than the positive control, acarbose (IC(50) = 92.94 ± 0.01 µM); a known α-glucosidase inhibitor (p < 0.05). The IC(50) values of epi-mukulin and (Z)-guggulsterone were found to be 159.33 and 132.14 µM, respectively. Other compounds showed weak α-glucosidase inhibitory effects, <30% inhibition of the enzyme activity at 0.1 mg mL(-1).
Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii,
El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita
, Natural product research, Volume 27, Issue 2, p.146-154, (2013)
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Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum,
El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Tezuka Yasuhiro, Hattori Masao, Kakiuchi Nobuko, Shimotohno Kunitada, Kawahata Takuya, and Otake Toru
, Phytochemistry, Volume 49, Issue 6, p.1651-1657, (1998)
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