Publications

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New paeonilactone-A adducts formed by anaerobic incubation of paeoniflorin with Lactobacillus brevis in the presence of arylthiols, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Chemical and pharmaceutical bulletin, Volume 49, Issue 7, p.918-920, (2001) Abstract
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Potent anticonvulsant paeonimetabolin-I derivatives obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MOHAMED Tarek A., MAHFOUZ Nadia M., and EL-GENDY Mahmoud A. , Chemical and pharmaceutical bulletin, Volume 46, Issue 9, p.1486-1487, (1998) Abstract
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Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MURAKAMI Yukihisa, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Biological and Pharmaceutical Bulletin, Volume 22, Issue 5, p.491-497, (1999) Abstract
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Effects of paeoniflorin derivatives on scopolamine-induced amnesia using a passive avoidance task in mice; structure-activity relationship, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MUKARAMI Yukihisa, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Biological and Pharmaceutical Bulletin, Volume 21, Issue 11, p.1174-1179, (1998) Abstract
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New oxypregnane glycosides from Caralluma penicillata, Abdel-Sattar, Essam, Meselhy Meselhy R., and Al-Yahya Mohammed Abdul-Aziz , Planta medica, Volume 68, Issue 05, p.430-434, (2002) Abstract
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Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells., Abdellatef, Amira A., Zhou Yue, Yamada Akane, Elmekkawy Sahar A., Kohyama Aki, Yokoyama Satoru, Meselhy Meselhy R., Matsuya Yuji, Sakurai Hiroaki, and Hayakawa Yoshihiro , Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Volume 140, p.111737, (2021) Abstract

Guggulsterone (GS) [4,17(20)-pregnadiene-3,16-dione], is the main active phytosterol constituent in guggul, the gum resin of Commiphora wightii (Arnott.) Bhand./Commiphora mukul Engl. tree, and is known for its medicinal effects. In this study, we report that GSD-1, a structurally-related synthetic GS derivative, strongly inhibits NF-κB activation induced by TNF-α. GSD-1 prevented the nuclear translocation of p65 through the blockade of IκBα degradation and p65 phosphorylation, and further inhibited the activation of upstream kinases, including transforming growth factor-β activated kinase 1 (TAK1), IκB kinase (IKK) α, and IKKβ. Furthermore, GSD-1 inhibited the cell-intrinsic activation of NF-κB, and exerted its direct anti-cancer and anti-metastatic effects in both murine and human breast cancer cell lines. This study demonstrated GSD-1 to be an attractive compound to target NF-κB activation that has potential for treating breast cancer growth and metastasis.

Iridoids from Phlomis aurea Decne growing in Egypt., Aboutabl, E. A., Meselhy M. R., and Afifi M. S. , Die Pharmazie, Volume 57, Issue 9, p.646-647, (2002) Abstract
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Phenolic constituents from Grevillea robusta, Ahmed, Amany S., Nakamura Norio, Meselhy Meselhy R., Makhboul Makhboul A., El-Emary Nasr, and Hattori Masao , Phytochemistry, Volume 53, Issue 1, p.149-154, (2000) Abstract
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Evaluation of the Anti-inflammatory and Antioxidant Activities of Selected Resin Exudates, Ali, Dalia E., Abdelrahman Rehab S., Gedaily Rania El A., Ezzat Shahira M., Meselhy Meselhy R., and Abdel-Sattar Essam , Tropical Journal of Natural Product Research, Volume 4, Issue 7, p.255-261, (2020)