Publications

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Conference Proceedings
Human Intestinal Bacteria Responsible for the Metabolism of Saikosaponins, Meselhy, Ragab Meselhy , The general meeting of Medical and Pharmaceutical Society for Wakan-yaku abstracts, Volume 16, p.5, (1999) Abstract
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Inhibitory effect of component from Ganoderma lucidum on the growth of human immunodeficiency virus (HIV) and the protease activity, Hattori, Masao, El-Mekkawy S., and Meselhy M. R. , Proceedings of the 1st International Symposium on Ganoderma Lucidum in Japan, Mizuno T, Ide N and Hasegawa Y (eds), p.128-135, (1997) Abstract
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Proc. Symp. Wakan-Yaku Proc. Symp. Wakan-Yaku 10, 103-108, 1999, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Proc. Symp. Wakan-Yaku, Volume 10, p.103-108, (1999) Abstract
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Journal Article
The 117th Annual Meeting of the Pharmaceutical Society of Japan, Sendai, March The 117th Annual Meeting of the Pharmaceutical Society of Japan, Sendai, March 29, 1994, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Biological & pharmaceutical bulletin, Volume 21, Issue 6, p.588-593, (1998) Abstract
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12-O-acetylphorbol-13-decanoate potently inhibits cytopathic effects of human immunodeficiency virus type 1 (HIV-1), without activation of protein kinase C, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , CHEMICAL AND PHARMACEUTICAL BULLETIN-TOKYO-, Volume 47, p.1346-1347, (1999) Abstract
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29A-01 Isolation of Human Intestinal Bacteria Capable of Transforming Rhein to Rhein Anthrone, Meselhy, Meselhy R. , 和漢医薬学会大会要旨集, Volume 15, p.19, (1998) Abstract
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Alkaloids Self-Assembled Supramolecular Nanocapsules with Enhanced Antioxidant and Cytotoxic Activities., Fahmy, Sherif Ashraf, Issa Marwa Y., Saleh Basma M., Meselhy Meselhy Ragab, and Azzazy Hassan Mohamed El-Said , ACS omega, Volume 6, Issue 18, p.11954-11963, (2021) Abstract

Amphiphilic macrocycles, such as -sulfonatocalix[6]arenes (-SC6), have demonstrated great potential in designing synthetic nanovesicles based on self-assembly approaches. These supramolecular nanovesicles are capable of improving the solubility, stability, and biological activity of various drugs. In the present study, the biologically active harmala alkaloid-rich fraction (HARF) was extracted from . seeds. Ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC/ESI-MS) analysis of HARF revealed 15 alkaloids. The reversed-phase high-performance liquid chromatography (RP-HPLC) analysis revealed three peaks: peganine, harmol, and harmine. The HARF was then encapsulated in -SC6 nanocapsules employing a thin-film hydration approach. The designed nanocapsules had an average particle size of 264.8 ± 10.6 nm, and a surface charge of -30.3 ± 2.2 mV. They were able to encapsulate 89.3 ± 1.4, 74.4 ± 1.3, and 76.1 ± 1.7% of the three harmala alkaloids; harmine, harmol, and peganine; respectively. The drug release experiments showed the potential of the designed nanocapsules to release their cargo at a pH of 5.5 (typical of cancerous tissue). The IC values of HARF encapsulated in -SC6 (H/-SC6 nanocapsules) were 5 and 2.7 μg/mL against ovarian cancer cells (SKOV-3) and breast adenocarcinoma cells (MCF-7), respectively. The prepared nanocapsules were found to be biocompatible when tested on human skin fibroblasts. Additionally, the antioxidant activity of the designed nanocapsules was 5 times that of the free powder fraction; the IC of the H/-SC6 nanocapsules was 30.1 ± 1.3 μg/mL, and that of the HARF was 169.3 ± 7.2 μg/mL. In conclusion, encapsulation of alkaloid-rich fraction into self-assembled -SC6 significantly increases its antioxidant and cytotoxic activities.

Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Tezuka Yasuhiro, Hattori Masao, Kakiuchi Nobuko, Shimotohno Kunitada, Kawahata Takuya, and Otake Toru , Phytochemistry, Volume 49, Issue 6, p.1651-1657, (1998) Abstract
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Anti-HIV-1 phorbol esters from the seeds of Croton tiglium, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Phytochemistry, Volume 53, Issue 4, p.457-464, (2000) Abstract
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Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity., Emad, Ayat M., Ali Sherifa F., Abdel-Rahman Engy A., Meselhy Meselhy R., Farag Mohamed A., Ali Sameh S., and Abdel-Sattar Essam A. , Journal of food biochemistry, p.e13399, (2020) Abstract

In the present work, antioxidant activity, total phenolics (TP), and total flavonoids (TF) contents of aqueous and methanol extracts of celery were determined, in addition to untargeted metabolites profiling its methanol celery root extract (MCRE) via UPLC-MS. Although MCRE exhibited the lowest TPC and TFC levels, it presented the most potential hydroxyl radical quenching effect using electron paramagnetic resonance spin trapping technique. Treatment of Acetaminophen-induced hepatotoxicity (AAH) rats with MCRE lowered serum levels of AST, ALT, ALP, TNF-α, and IL-1β significantly. Additionally, MCRE significantly increased total antioxidant capacity (TAC) and glutathione (GSH) levels relative to AAH rats. Strikingly, Kaplan-Meier survival analysis of all groups revealed a 100% prevention of acetaminophen-induced mortality of rats by MCRE pretreatment (100 mg/kg/day). MCRE prevented AAH-associated severe weight loss and elicited normal behavior in the rescued rats. Our results suggest that pretreatment with MCRE can mitigate against overdosed acetaminophen-induced acute liver failure and warrant further investigations on the potential of postinjury intervention. PRACTICAL APPLICATIONS: Acetaminophen-induced hepatotoxicity (AAH) accounts for alerting numbers of overdose-related acute liver failure and liver transplant cases with increased morbidity and mortality rates. Currently proposed mechanisms implicate mitochondria-mediated oxidative stress and inflammation in the pathogenesis of AAH, which underline current interventions employing antioxidants to combat liver damage by over-dosed acetaminophen. The present work uncovers potent protective effects of some celery extracts (and their fractions) against acetaminophen-induced oxidative stress and inflammation. Treatment of rats with fatal liver injury with methanol extract of celery root significantly reduced secretion of liver enzymes and markedly decreased inflammatory as well as oxidative stress markers in these animals. This, in turn, rescued challenged rats exposed to fatal doses of acetaminophen completely, which establishes methanol extracts of celery roots as effective therapeutic intervention against AAH. The antioxidant capacity of the extracts was determined using EPR technique, and the secondary metabolites related to antioxidant activity were characterized via UPLC-MS.

Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MURAKAMI Yukihisa, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Biological and Pharmaceutical Bulletin, Volume 22, Issue 5, p.491-497, (1999) Abstract
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Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells, Tohda, Chihiro, Matsumoto Noriaki, Zou Kun, Meselhy Meselhy R., and Komatsu Katsuko , The Japanese Journal of Pharmacology, Volume 90, Issue 3, p.254-262, (2002) Abstract
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Aβ (25–35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins, Tohda, Chihiro, Matsumoto Noriaki, Zou Kun, Meselhy Meselhy R., and Komatsu Katsuko , Neuropsychopharmacology, Volume 29, Issue 5, p.860, (2004) Abstract
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Biotransformation of (-)-epicatechin 3-O-gallate by human intestinal bacteria, Meselhy, Meselhy R., Nakamura Norio, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 45, Issue 5, p.888-893, (1997) Abstract
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Biotransformation of a C-Glycosylflavone, Abrusin 2"-O-β-D-Apioside, by Human Intestinal Bacteria, Li, Yan, Meselhy Meselhy R., Wang Li-Quan, Nakamura Norio, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 48, Issue 8, p.1239-1241, (2000) Abstract
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Biotransformation of shikonin by human intestinal bacteria, Meselhy, Meselhy R., KADOTA Shigetoshi, Tsubono Koji, Hattori Masao, and NAMBA Tsuneo , Tetrahedron, Volume 50, Issue 10, p.3081-3098, (1994) Abstract
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Chemical and biological study of Manilkara zapota (L.) Van Royen leaves (Sapotaceae) cultivated in Egypt, m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., Meselhy Meselhy R., and Shazly Amani H. , Pharmacognosy research, Volume 4, Issue 2, p.85, (2012) Abstract
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Comparative Antioxidant Activities of Selected Apiaceous Plants, Emad, Ayat M., Ali Sherifa F., Meselhy Meselhy R., and Sattar Essam A. , Pharmacognosy Journal, Volume 11, Issue 6, p.1-6, (2019)
Comparative study of chemical constituents of rhubarb from different origins, Komatsu, Katsuko, Nagayama Yorinobu, Tanaka Ken, Ling Yun, Cai Shao-Qing, Omote Takayuki, and Meselhy Meselhy Ragab , Chemical and pharmaceutical bulletin, Volume 54, Issue 11, p.1491-1499, (2006) Abstract
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Constituents from Moghat, the roots of Glossostemon bruguieri (Desf.), Meselhy, Meselhy R. , Molecules, Volume 8, Issue 8, p.614-621, (2003) Abstract
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Conversion of aconitine to lipoaconitine by human intestinal bacteria and their antinociceptive effects in mice, Kawata, Yukio, Cho-mei MA, Nakamura Norio, WANG Hong, NAMBA Tsuneo, SATOH Kazuya, and KURAISHI Yasushi , 和漢医薬学雑誌= Journal of traditional medicines, Volume 16, Issue 1, p.15-23, (1999) Abstract
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Cytotoxicity of shikonin metabolites with biotransformation of human intestinal bacteria, MIN, Byung-Sun, Meselhy Meselhy-R, Hattori Masao, Kim Hwan-Mook, and Kim Young-Ho , Journal of microbiology and biotechnology, Volume 10, Issue 4, p.514-517, (2000) Abstract
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Dammarane-Type Saponins from Panax j aponicus and Their Neurite Outgrowth Activity in SK-N-SH Cells, Zou, Kun, Zhu Shu, Meselhy Meselhy R., Tohda Chihiro, Cai Shaoqing, and Komatsu Katsuko , Journal of natural products, Volume 65, Issue 9, p.1288-1292, (2002) Abstract
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Dammarane-type triterpenes from Cordia spinescens, Nakamura, Norio, Kojima Shiho, Lim Yasmina Aura, Meselhy Meselhy R., Hattori Masao, Gupta Mahabir P., and Correa Mireya , Phytochemistry, Volume 46, Issue 6, p.1139-1141, (1997) Abstract
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Developing of anti-HIV agents from natural resources (Chemical & Pharmacological study), Meselhy, Meselhy Ragab, El-Mekkawy Sahar, Ma Chaomei, Nakamura Norio, TEWTRAKUL Supinya, and Hattori Masao , 和漢医薬学雑誌, Volume 22, Issue 1, p.116-128, (2005) Abstract
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Development of a high performance liquid chromatographic method for systematic quantitative analysis of chemical constituents in rhubarb, Komatsu, Katsuko, Nagayama Yorinobu, Tanaka Ken, Ling Yun, Basnet Purusotam, and Meselhy Meselhy Ragab , Chemical and pharmaceutical bulletin, Volume 54, Issue 7, p.941-947, (2006) Abstract
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Disposition of paeoniflorin and paeonimetabolin I in rats after oral administration of Toki-Shakuyaku-San (TS) and Shakuyaku-Kanzo-To (SK), Meselhy, Meselhy R., Heikal Ola A., Akao Teruaki, KHOJIMATOV OLIM, Hattori Masao, ONO HIROMASA, and SADAKANE CHIHARU , Natural medicines= 生薬學雜誌, Volume 52, Issue 3, p.265-268, (1998) Abstract
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Diterpene acids from Conyza incana, Galal, Ahmed M., Abdel-Sattar Essam, El-Feraly Farouk S., Mossa Jaber S., Meselhy Meselhy R., KADOTA Shigetoshi, and NAMBA Tsuneo , Phytochemistry, Volume 48, Issue 1, p.159-163, (1998) Abstract
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Effect of tinctormine on contraction and Ca2+ currents in single cardiac myocytes from dog, Meselhy, M. R., Momose Y., Hatakeyama N., Kadota S., Hattori M., and Namba T. , Phytomedicine, Volume 1, Issue 4, p.277-281, (1995) Abstract
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Effects of paeoniflorin derivatives on scopolamine-induced amnesia using a passive avoidance task in mice; structure-activity relationship, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MUKARAMI Yukihisa, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Biological and Pharmaceutical Bulletin, Volume 21, Issue 11, p.1174-1179, (1998) Abstract
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Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum, GAO, Jiang Jing, MIN Byung Sun, Akao Teruaki, Meselhy Meselhy R., and Nakamura Norio , 和漢医薬学雑誌, Volume 18, Issue 4, p.154-160, (2001) Abstract
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Enzymes responsible for the metabolism of saikosaponins from Eubacterium sp. A-44, a human intestinal anaerobe, Kida, Hiroaki, Akao Teruaki, MESELHY Meselhy, and Hattori Masao , Biological and Pharmaceutical Bulletin, Volume 20, Issue 12, p.1274-1278, (1997) Abstract
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Essential oil of cultivated in Egypt: seasonal variation in chemical composition and anticholinesterase activity., Madi, Yasmine F., Choucry Mouchira A., Meselhy Meselhy R., and El-Kashoury El-Sayeda A. , Natural product research, p.1-5, (2020) Abstract

The yield of essential oil obtained by hydrodistillation of fresh leaves ranged from 0.15% to 0.46% w/w; being the highest in spring and the lowest in winter. The oil sample obtained in winter exhibited a moderate acetylcholinesterase inhibitory activity (IC 2.86 ± 0.17 mg/mL), compared to physostigmine (IC 0.012 mg/mL), while other samples were relatively weak (IC values of 2.86-5.40 mg/mL). In all samples, oxygenated monoterpenes were predominating (73.22-89.32%). GC-MS identified a total of 61, 25, 50 and 63 components in oil samples obtained in spring, summer, autumn and winter, respectively. Citral content was the highest in autumn and summer samples (82.02% and 80.01% citral; respectively) and the lowest in winter sample (60.01%). Citral, isolated from the oil demonstrated a relatively potent anticholinesterase activity (IC 0.21 ± 0.01 mg/mL).

Evaluation of the Anti-inflammatory and Antioxidant Activities of Selected Resin Exudates, Ali, Dalia E., Abdelrahman Rehab S., Gedaily Rania El A., Ezzat Shahira M., Meselhy Meselhy R., and Abdel-Sattar Essam , Tropical Journal of Natural Product Research, Volume 4, Issue 7, p.255-261, (2020)
Four mono-tetrahydrofuran ring acetogenins, montanacins BE, from Annona montana, Wang, Li-Quan, Nakamura Norio, Meselhy Meselhy R., Hattori Masao, ZHAO Wei-Min, CHENG Kin-Fai, YANG Ren-Zhou, and QIN Guo-Wei , Chemical and pharmaceutical bulletin, Volume 48, Issue 8, p.1109-1113, (2000) Abstract
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Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation, Basu, Nikhil K., Kubota Shigeki, Meselhy Meselhy R., Ciotti Marco, Chowdhury Bhabadeb, Hartori Masao, and Owens Ida S. , Journal of Biological Chemistry, Volume 279, Issue 27, p.28320-28329, (2004) Abstract
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Guaianolides from Centaurea scoparia, Helal, Amr M., Nakamura Norio, Meselhy Meselhy R., El-Fishawy Ahlam M., Hattori Masao, and Mahran Gamal H. , Phytochemistry, Volume 45, Issue 3, p.551-554, (1997) Abstract
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The heterocyclic ring fission and dehydroxylation of catechins and related compounds by Eubacterium sp. strain SDG-2, a human intestinal bacterium, Wang, Li-Quan, Meselhy Meselhy Ragab, Li Yan, Nakamura Norio, MIN Byung-Sun, QIN Guo-Wei, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 49, Issue 12, p.1640-1643, (2001) Abstract
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Hopane-type saponins from Polycarpon succulentum growing in Egypt, Meselhy, Meselhy R., and Aboutabl El-Sayed A. , Phytochemistry, Volume 44, Issue 5, p.925-929, (1997) Abstract
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