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和漢医薬学雑誌= Journal of traditional medicines 20 (5), 201-207, 2003-10-20, Xiong, Xin, Zhai Suodi, Yao Zhongqiang, Tazawa Takako, Zhao Huai-qing, Li Yan, Meselhy Meselhy Ragab, Nakamura Norio, Akao Teruaki, and Hattori Masao , Prog. Neurobiol, Volume 56, p.211-235, (1998) Abstract
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Two new quinochalcone yellow pigments from Carthamus tinctorius and Ca2+ antagonistic activity of tinctormine, Meselhy, Meselhy R., KADOTA Shigetoshi, Momose Yasunori, HATAKEYAMA Noboru, KUSAI Akihiko, Hattori Masao, and NAMBA Tsuneo , Chemical and pharmaceutical bulletin, Volume 41, Issue 10, p.1796-1802, (1993) Abstract
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Transformation of shikonin by a cell-free extract of Eubacterium sp. A-44, a human intestinal bacterium, Meselhy, Meselhy R., Nishimoto Eri, Akao Teruaki, and Hattori Masao , (2001) Abstract
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TINCTRMINE, A NOVEL Ca2+ ANTAGONIST N-CONTAINING QUINOCHALCONE C-GLYCOSIDE FROM CARTHAMUS TINCTORIUS L., Meselhy, Meselhy R., KADOTA Shigetoshi, Momose Yasunori, Hattori Masao, and NAMBA Tsuneo , Chemical and pharmaceutical bulletin, Volume 40, Issue 12, p.3355-3357, (1992) Abstract
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Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii., El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita , Natural product research, 2013, Volume 27, Issue 2, p.146-54, (2013) Abstract

Three new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangambin, gugglsterol I, (E)-guggulsterone and (Z)-guggulsterone. Their structures were elucidated on the basis of different spectroscopic data. α-Glucosidase inhibitory effects of HSF and the isolated compounds were evaluated calorimetrically. The HSF showed significant α-glucosidase inhibitory effect [IC(50) value of 140 µg mL(-1) (p < 0.05)]. Under the assay conditions, diasesartemin (IC(50) = 60.6 ± 0.01 µM) was found to be more potent than the positive control, acarbose (IC(50) = 92.94 ± 0.01 µM); a known α-glucosidase inhibitor (p < 0.05). The IC(50) values of epi-mukulin and (Z)-guggulsterone were found to be 159.33 and 132.14 µM, respectively. Other compounds showed weak α-glucosidase inhibitory effects, <30% inhibition of the enzyme activity at 0.1 mg mL(-1).

Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii, El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita , Natural product research, Volume 27, Issue 2, p.146-154, (2013) Abstract
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Simultaneous determination of triterpene saponins in ginseng drugs by high-performance liquid chromatography, Zhu, Shu, Zou Kun, Cai Shaoqing, Meselhy Meselhy Ragab, and Komatsu Katsuko , Chemical and pharmaceutical bulletin, Volume 52, Issue 8, p.995-998, (2004) Abstract
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Shikometabolins A, B, C and D, novel dimeric naphthoquinone metabolites obtained from shikonin by human intestinal bacteria, Meselhy, Meselhy R., KADOTA Shigetoshi, Tsubono Koji, KUSAI Akihiko, Hattori Masao, and NAMBA Tsuneo , Tetrahedron letters, Volume 35, Issue 4, p.583-586, (1994) Abstract
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Sesquiterpenes from Cymbopogon proximus, El-Askary, Hesham I., Meselhy Meselhy R., and Galal Ahmed M. , Molecules, Volume 8, Issue 9, p.670-677, (2003) Abstract
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Quinic acid derivatives from Artemisia annua L. leaves; biological activities and seasonal variation, H.I. El-Askary, S.S. Mohamed, El-Gohari H. M. A., Ezzat S. M., and Meselhy M. R. , South African Journal of Botany, Volume 128, p.200-208, (2020)
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Proc. Symp. Wakan-Yaku Proc. Symp. Wakan-Yaku 10, 103-108, 1999, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Proc. Symp. Wakan-Yaku, Volume 10, p.103-108, (1999) Abstract
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Potent anticonvulsant paeonimetabolin-I derivatives obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MOHAMED Tarek A., MAHFOUZ Nadia M., and EL-GENDY Mahmoud A. , Chemical and pharmaceutical bulletin, Volume 46, Issue 9, p.1486-1487, (1998) Abstract
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Polyphenols LC-MS2 profile of Ajwa date fruit (Phoenix dactylifera L.) and their microemulsion: Potential impact on hepatic fibrosis, Nematallah, Khaled A., Ayoub Nahla A., Abdelsattar Essam, Meselhy Meselhy R., Elmazar Mohey M., El-Khatib Ahmed H., Linscheid Michael W., Hathout Rania M., Godugu Kavitha, and Adel Aya , Journal of Functional Foods, Volume 49, p.401-411, (2018) Abstract
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Phenolics from Maytenus senegalensis, Hussein, Ghazi, Nakamura Norio, Meselhy Meselhy R., and Hattori Masao , Phytochemistry, Volume 50, Issue 4, p.689-694, (1999) Abstract
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Phenolic constituents from Grevillea robusta, Ahmed, Amany S., Nakamura Norio, Meselhy Meselhy R., Makhboul Makhboul A., El-Emary Nasr, and Hattori Masao , Phytochemistry, Volume 53, Issue 1, p.149-154, (2000) Abstract
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Pharmacokinetic study of paeoniflorin, paeonimetabolin-I and glycyrrhetic acid in humans after oral administration of paeony root, Glycyrrhiza and Shakuyaku-kanzo-to (Shao-Yao-Gan-Cao-Tang)., Bando, Miyuki, Shibahara Naotoshi, Shimada Yutaka, Meselhy Meselhy R., Akao Teruaki, Itoh Takashi, and Terasawa Katsutoshi , Journal of Traditional Medicines, Volume 17, Issue 1, p.26-33, (2000) Abstract
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New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits., m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., and Meselhy Meselhy R. , Pharmacognosy research, 2013 Apr, Volume 5, Issue 2, p.55-9, (2013) Abstract

β-amyrin-3-(3'-dimethyl) butyrate, a new natural compound was isolated from the fruits of Manilkara zapota (L.) Van Royen, in addition to lupeol-3-acetate and 4-caffeoylquinic acid (cryptochlorogenic acid). The structures of these compounds were identified using different spectral methods (IR, MS, UV, (1)H-NMR, (13)C-NMR and 2D-NMR). The alcoholic and aqueous extracts of the unripe fruits, in addition to their aqueous homogenate exhibited antioxidant, antihyperglycemic and hypocholesterolemic activities.

New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits, m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., and Meselhy Meselhy R. , Pharmacognosy research, Volume 5, Issue 2, p.55, (2013) Abstract
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New paeonilactone-A adducts formed by anaerobic incubation of paeoniflorin with Lactobacillus brevis in the presence of arylthiols, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Chemical and pharmaceutical bulletin, Volume 49, Issue 7, p.918-920, (2001) Abstract
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New oxypregnane glycosides from Caralluma penicillata, Abdel-Sattar, Essam, Meselhy Meselhy R., and Al-Yahya Mohammed Abdul-Aziz , Planta medica, Volume 68, Issue 05, p.430-434, (2002) Abstract
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A new enzyme immunoassay for aconitine and its application to quantitative determination of aconitine levels in plasma, Tazawa, Takako, Zhao Huai-qing, Li Yan, Meselhy Meselhy Ragab, Nakamura Norio, Akao Teruaki, and Hattori Masao , Biological and Pharmaceutical Bulletin, Volume 26, Issue 9, p.1289-1294, (2003) Abstract
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Neuroprotective effect of Salvia splendens extract and its constituents against AlCl3‑induced Alzheimer’s disease in rats, Salma Ahmed El‑Sawi, Shahira Mohamed Ezzat, Hanan Farouk Aly, Rana Merghany Merghany, and Meselhy Meselhy Ragab , Advances in Traditional Medicine, Volume Online version, (2019)
Natural Products as Antiviral Agents Natural Products as Antiviral Agents, 1-29, 1992, El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Chemical & pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002) Abstract
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Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria, El-Mekkawy, Sahar, Meselhy M. R., Kawata Yukio, KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Planta medica, Volume 59, Issue 04, p.347-350, (1993) Abstract
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Metabolism of safflor yellow B by human intestinal bacteria, Meselhy, M. R., KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Journal of natural products, Volume 56, Issue 1, p.39-45, (1993) Abstract
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Metabolism and pharmacokinetics of paeoniflorin, a bioactive component from Peony roots, Meselhy, Meselhy R., and Hattori Masao , 和漢薬研究所年報, Volume 28, p.3-13, (2002) Abstract
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Metabolism and pharmacokinetics of orally administered saikosaponin b1 in conventional, germ-free and Eubacterium sp. A-44-infected gnotobiote rats, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Biological and Pharmaceutical Bulletin, Volume 21, Issue 6, p.588-593, (1998) Abstract
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Lanostane-type triterpenes from the sporoderm-broken spores of Ganoderma lucidum, Ma, Bing-Ji, Zhou Yan, Ruan Yuan, Ma Jin-Chuan, Ren Wei, and Wen Chun-Nan , The Journal of antibiotics, Volume 65, Issue 3, p.165, (2012) Abstract
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Isolation and identification of human intestinal bacteria capable of hydrolyzing saikosaponins, Teruaki, AKAO‘, and HATTORIW Masao , Journal of Traditional Medicines, Volume 14, p.34-40, (1997) Abstract
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Iridoids from Phlomis aurea Decne growing in Egypt., Aboutabl, E. A., Meselhy M. R., and Afifi M. S. , Die Pharmazie, Volume 57, Issue 9, p.646-647, (2002) Abstract
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Intestinal injury can be effectively prevented by in gamma irradiated rats., Khayyal, Mohamed T., El-Baz Farouk K., Meselhy Meselhy R., Ali Gamila H., and El-Hazek Rania M. , Heliyon, Volume 5, Issue 5, p.e01814, (2019) Abstract

is one of the most common microalgae that is used as human food. It is isolated from the salty lakes in El-Fayoum and Lake of Bardawil-Sinai in Egypt and can withstand very high concentrations of salt: The potentiality of , a unicellular biflagellate green alga to protect against intestinal injury induced after radiation exposure was studied. was given orally in doses of 100 and 200 mg/kg to male Wistar rats for 5 days before exposure to 6 Gray (Gy) gamma radiation and continued for a further two days. Rats were sacrificed 24 h later and intestinal segments were dissected out. One segment was examined histologically and another was used to prepare homogenates to assess relevant biochemical parameters reflecting intestinal injury. Radiation exposure led to a rise in the histological damage score, an increase in tissue tumor necrosis factor (TNF-α), interleukin (IL-1β) and thiobarbituric acid reactive substances (TBARS) but a reduction in tissue reduced glutathione (GSH) and in serum citrulline. Pretreatment with either dose of effectively reduced the severity of intestinal mucositis induced by gamma radiation.

Inhibitory effects of egyptian folk medicines oh human immunodeficiency virus (HIV) reverse transcriptase, El-Mekkawy, Sahar, Meselhy Meselhy R., KUSUMOTO Ines Tomoco, KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Chemical and Pharmaceutical Bulletin, Volume 43, Issue 4, p.641-648, (1995) Abstract
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Inhibitory effect of component from Ganoderma lucidum on the growth of human immunodeficiency virus (HIV) and the protease activity, Hattori, Masao, El-Mekkawy S., and Meselhy M. R. , Proceedings of the 1st International Symposium on Ganoderma Lucidum in Japan, Mizuno T, Ide N and Hasegawa Y (eds), p.128-135, (1997) Abstract
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Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents, Meselhy, Meselhy R. , Phytochemistry, Volume 62, Issue 2, p.213-218, (2003) Abstract
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Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives, El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Chemical and pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002) Abstract
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In vivo Antiviral Activity of Stephania cepharantha against Herpes Simplex Virus Type‐1, ari Nawawi, As', Nakamura Norio, Meselhy Meselhy R., Hattori Masao, Kurokawa Masahiko, Shiraki Kimiyasu, Kashiwaba Noriaki, and Ono Minoru , Phytotherapy research, Volume 15, Issue 6, p.497-500, (2001) Abstract
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Human intestinal Bacteroides spp. RHEIN-I and RHEIN-II capable of transforming rhein to rheinanthrone, induce rhein-dependent diarrhea in rats, Meselhy, Meselhy Ragab, Nishimoto Eri, Akao Teruaki, and Hattori Masao , J Trad Med, Volume 18, Issue 4, p.169-176, (2001) Abstract
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Human Intestinal Bacteria Responsible for the Metabolism of Saikosaponins, Meselhy, Ragab Meselhy , The general meeting of Medical and Pharmaceutical Society for Wakan-yaku abstracts, Volume 16, p.5, (1999) Abstract
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