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Dammarane-Type Saponins from Panax j aponicus and Their Neurite Outgrowth Activity in SK-N-SH Cells, Zou, Kun, Zhu Shu, Meselhy Meselhy R., Tohda Chihiro, Cai Shaoqing, and Komatsu Katsuko , Journal of natural products, Volume 65, Issue 9, p.1288-1292, (2002) Abstract
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Simultaneous determination of triterpene saponins in ginseng drugs by high-performance liquid chromatography, Zhu, Shu, Zou Kun, Cai Shaoqing, Meselhy Meselhy Ragab, and Komatsu Katsuko , Chemical and pharmaceutical bulletin, Volume 52, Issue 8, p.995-998, (2004) Abstract
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和漢医薬学雑誌= Journal of traditional medicines 20 (5), 201-207, 2003-10-20, Xiong, Xin, Zhai Suodi, Yao Zhongqiang, Tazawa Takako, Zhao Huai-qing, Li Yan, Meselhy Meselhy Ragab, Nakamura Norio, Akao Teruaki, and Hattori Masao , Prog. Neurobiol, Volume 56, p.211-235, (1998) Abstract
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The heterocyclic ring fission and dehydroxylation of catechins and related compounds by Eubacterium sp. strain SDG-2, a human intestinal bacterium, Wang, Li-Quan, Meselhy Meselhy Ragab, Li Yan, Nakamura Norio, MIN Byung-Sun, QIN Guo-Wei, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 49, Issue 12, p.1640-1643, (2001) Abstract
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Four mono-tetrahydrofuran ring acetogenins, montanacins BE, from Annona montana, Wang, Li-Quan, Nakamura Norio, Meselhy Meselhy R., Hattori Masao, ZHAO Wei-Min, CHENG Kin-Fai, YANG Ren-Zhou, and QIN Guo-Wei , Chemical and pharmaceutical bulletin, Volume 48, Issue 8, p.1109-1113, (2000) Abstract
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Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone, Wang, Li-Quan, Meselhy Meselhy R., Li Yan, QIN Guo-Wei, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 48, Issue 11, p.1606-1610, (2000) Abstract
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Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells, Tohda, Chihiro, Matsumoto Noriaki, Zou Kun, Meselhy Meselhy R., and Komatsu Katsuko , The Japanese Journal of Pharmacology, Volume 90, Issue 3, p.254-262, (2002) Abstract
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Aβ (25–35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins, Tohda, Chihiro, Matsumoto Noriaki, Zou Kun, Meselhy Meselhy R., and Komatsu Katsuko , Neuropsychopharmacology, Volume 29, Issue 5, p.860, (2004) Abstract
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Isolation and identification of human intestinal bacteria capable of hydrolyzing saikosaponins, Teruaki, AKAO‘, and HATTORIW Masao , Journal of Traditional Medicines, Volume 14, p.34-40, (1997) Abstract
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A new enzyme immunoassay for aconitine and its application to quantitative determination of aconitine levels in plasma, Tazawa, Takako, Zhao Huai-qing, Li Yan, Meselhy Meselhy Ragab, Nakamura Norio, Akao Teruaki, and Hattori Masao , Biological and Pharmaceutical Bulletin, Volume 26, Issue 9, p.1289-1294, (2003) Abstract
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Neuroprotective effect of Salvia splendens extract and its constituents against AlCl3‑induced Alzheimer’s disease in rats, Salma Ahmed El‑Sawi, Shahira Mohamed Ezzat, Hanan Farouk Aly, Rana Merghany Merghany, and Meselhy Meselhy Ragab , Advances in Traditional Medicine, Volume Online version, (2019)
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UPLC-PDA-ESI/MS metabolic profiling of dill shoots bioactive fraction; evidence of its antioxidant and hepatoprotective effects in vitro and in vivo., Rasheed, Dalia M., Emad Ayat M., Ali Sherifa F., Ali Sameh S., Farag Mohamed A., Meselhy Meselhy R., and Sattar Essam A. , Journal of food biochemistry, p.e13741, (2021) Abstract

Hydroxyl radical ( OH) scavenging capacity of aqueous dill (Anethum graveolens L.) shoot (ADSh) extract was assessed using electron paramagnetic resonance (EPR) spectroscopy. ADSh extract (at concentrations of 0.5 and 10 mg/ml) exerted high (OH) radical scavenging power. ADSh extract was further fractionated on Diaion HP-20 column to yield five fractions. EPR spin-trapping assay revealed fraction 4 (eluted with 75% aq. MeOH) to possess ( OH) radical scavenging capacity over a concentration range (0.01-10 mg/ml), whereas fraction 2 (eluted with 25% aq. MeOH) appeared to be pro-oxidant at concentration 0.01 mg/ml. UPLC-PDA-ESI-MS metabolite profiling of ADSh extract revealed 87 metabolites, of which 64 compounds were identified in fraction 4, the most active fraction. Furthermore, ADSh extract demonstrated a hepatoprotective effect against acetaminophen (APAP)-induced hepatotoxicity in rats. Pretreatment of rats with ADSh extract (200 mg/kg b.wt) markedly attenuated the increased in the serum hepatic enzyme levels. It also increased free glutathione level and total antioxidant capacity in the serum of treated rats. [Correction added on May 3, 2021, after first online publication: "rates" has been changed to "rats" in the previous sentence.] Additionally, levels of (TNF-α and IL-1β) were back to almost normal levels compared to the control group. The above findings suggest that ADSh extract has a protective effect against APAP-induced liver damage.

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Polyphenols LC-MS2 profile of Ajwa date fruit (Phoenix dactylifera L.) and their microemulsion: Potential impact on hepatic fibrosis, Nematallah, Khaled A., Ayoub Nahla A., Abdelsattar Essam, Meselhy Meselhy R., Elmazar Mohey M., El-Khatib Ahmed H., Linscheid Michael W., Hathout Rania M., Godugu Kavitha, and Adel Aya , Journal of Functional Foods, Volume 49, p.401-411, (2018) Abstract
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Cheminformatics Application in the Phytochemical and Biological Study of Eucalyptus globulus L. Bark as a Potential Hepatoprotective Drug, Nematallah, Khaled A., Elmekkawy Sahar, Abdollah Maha RA, Elmazar Mohey M., Abdel-Sattar Essam, and Meselhy Meselhy Ragab , ACS omega, Volume 7, Number 9, p.7945–7956, (2022) Abstract
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In vivo Antiviral Activity of Stephania cepharantha against Herpes Simplex Virus Type‐1, ari Nawawi, As', Nakamura Norio, Meselhy Meselhy R., Hattori Masao, Kurokawa Masahiko, Shiraki Kimiyasu, Kashiwaba Noriaki, and Ono Minoru , Phytotherapy research, Volume 15, Issue 6, p.497-500, (2001) Abstract
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Dammarane-type triterpenes from Cordia spinescens, Nakamura, Norio, Kojima Shiho, Lim Yasmina Aura, Meselhy Meselhy R., Hattori Masao, Gupta Mahabir P., and Correa Mireya , Phytochemistry, Volume 46, Issue 6, p.1139-1141, (1997) Abstract
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Cytotoxicity of shikonin metabolites with biotransformation of human intestinal bacteria, MIN, Byung-Sun, Meselhy Meselhy-R, Hattori Masao, Kim Hwan-Mook, and Kim Young-Ho , Journal of microbiology and biotechnology, Volume 10, Issue 4, p.514-517, (2000) Abstract
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Hopane-type saponins from Polycarpon succulentum—II, Meselhy, Meselhy R. , Phytochemistry, Volume 48, Issue 8, p.1415-1421, (1998) Abstract
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Human intestinal Bacteroides spp. RHEIN-I and RHEIN-II capable of transforming rhein to rheinanthrone, induce rhein-dependent diarrhea in rats, Meselhy, Meselhy Ragab, Nishimoto Eri, Akao Teruaki, and Hattori Masao , J Trad Med, Volume 18, Issue 4, p.169-176, (2001) Abstract
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Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents, Meselhy, Meselhy R. , Phytochemistry, Volume 62, Issue 2, p.213-218, (2003) Abstract
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Shikometabolins A, B, C and D, novel dimeric naphthoquinone metabolites obtained from shikonin by human intestinal bacteria, Meselhy, Meselhy R., KADOTA Shigetoshi, Tsubono Koji, KUSAI Akihiko, Hattori Masao, and NAMBA Tsuneo , Tetrahedron letters, Volume 35, Issue 4, p.583-586, (1994) Abstract
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Metabolism and pharmacokinetics of paeoniflorin, a bioactive component from Peony roots, Meselhy, Meselhy R., and Hattori Masao , 和漢薬研究所年報, Volume 28, p.3-13, (2002) Abstract
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Transformation of shikonin by a cell-free extract of Eubacterium sp. A-44, a human intestinal bacterium, Meselhy, Meselhy R., Nishimoto Eri, Akao Teruaki, and Hattori Masao , (2001) Abstract
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Developing of anti-HIV agents from natural resources (Chemical & Pharmacological study), Meselhy, Meselhy Ragab, El-Mekkawy Sahar, Ma Chaomei, Nakamura Norio, TEWTRAKUL Supinya, and Hattori Masao , 和漢医薬学雑誌, Volume 22, Issue 1, p.116-128, (2005) Abstract
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Chemical and biological assessment of high value pharmaceutical raw material from Egyptian orange peel, Meselhy, Meselhy R., Ezzat Shahira M., Ali Dalia El-Sheikh, El-Adl Mohamed, El-Shafei Reham A., El-Aziz Marwa Abd M., and Abdel-Sattar Essam , (2022) Abstract
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Two new quinochalcone yellow pigments from Carthamus tinctorius and Ca2+ antagonistic activity of tinctormine, Meselhy, Meselhy R., KADOTA Shigetoshi, Momose Yasunori, HATAKEYAMA Noboru, KUSAI Akihiko, Hattori Masao, and NAMBA Tsuneo , Chemical and pharmaceutical bulletin, Volume 41, Issue 10, p.1796-1802, (1993) Abstract
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Biotransformation of (-)-epicatechin 3-O-gallate by human intestinal bacteria, Meselhy, Meselhy R., Nakamura Norio, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 45, Issue 5, p.888-893, (1997) Abstract
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Human Intestinal Bacteria Responsible for the Metabolism of Saikosaponins, Meselhy, Ragab Meselhy , The general meeting of Medical and Pharmaceutical Society for Wakan-yaku abstracts, Volume 16, p.5, (1999) Abstract
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Constituents from Moghat, the roots of Glossostemon bruguieri (Desf.), Meselhy, Meselhy R. , Molecules, Volume 8, Issue 8, p.614-621, (2003) Abstract
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Disposition of paeoniflorin and paeonimetabolin I in rats after oral administration of Toki-Shakuyaku-San (TS) and Shakuyaku-Kanzo-To (SK), Meselhy, Meselhy R., Heikal Ola A., Akao Teruaki, KHOJIMATOV OLIM, Hattori Masao, ONO HIROMASA, and SADAKANE CHIHARU , Natural medicines= 生薬學雜誌, Volume 52, Issue 3, p.265-268, (1998) Abstract
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Effect of tinctormine on contraction and Ca2+ currents in single cardiac myocytes from dog, Meselhy, M. R., Momose Y., Hatakeyama N., Kadota S., Hattori M., and Namba T. , Phytomedicine, Volume 1, Issue 4, p.277-281, (1995) Abstract
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Preparation of Lignan-Rich Extract from the Aerial Parts of Using Nonconventional Methods., Meselhy, Meselhy R., Abdel-Sattar Ola E., El-Mekkawy Sahar, El-Desoky Ahmed M., Mohamed Shanaz O., Mohsen Sobhy M., Abdel-Sattar Essam, and Halawany Ali El- , Molecules (Basel, Switzerland), Volume 25, Issue 5, (2020) Abstract

Phyllanthin and related lignans were found to be responsible, at least in part, for most of the activity of species. This observation encouraged the authors to develop methods for the preparation of an extract rich in phyllanthin and related lignans from the aerial parts of L. Direct extraction with solvents produced extracts with variable yields and contents of lignans. Lignans were identified by LC-ESI-MS analysis as phyllanthin (used as marker substance), hypophyllanthin, phylltetralin, nirtetralin, and niranthin. Extraction with boiling water produced 18.10 g% (/) extract with a trace amount of lignans (phyllanthin content of 0.33 ± 0.10 mg/g extract), while extraction with MeOH gave 3.6 g% / extract with a low phyllanthin content (3.1 mg/g extract), as determined by HPLC. However, Soxhlet extraction with hexane, CHCl, or acetone gave extracts with low yields (0.82, 1.12, and 3.40 g% /, respectively) and a higher phyllanthin contents (36.2 ± 2.6, 11.7 ± 1.68, and 11.7 ± 1.10 mg/g extract, respectively). Extraction quality and efficiency were optimized by adopting the following three different approaches: (1) Alkaline digestion of the plant material with 30% potassium hydroxide yielded 3.1 g% / of purified extract with high phyllanthin content (22.34 ± 0.13 mg/g); (2) microwave-assisted extraction using 80% MeOH gave an extract with a better yield (8.13 g% /) and phyllanthin content (21.2 ± 1.30 mg/g) (after filtration through a Diaion HP-20 column); and (3) treatment of the ground plant material at 50 °C with two hydrolytic enzymes, cellulase (9 U/g for 12 h) and then, protease (4 U/g up to 72 h) optimized the yield of extract (13.92 g% /) and phyllanthin content (25.9 mg/g extract and total lignans content of 85.87 mg/g extract). In conclusion, the nonconventional methods presented here are superior for optimizing the yield of extract and its lignan contents from the aerial parts of .

Biotransformation of shikonin by human intestinal bacteria, Meselhy, Meselhy R., KADOTA Shigetoshi, Tsubono Koji, Hattori Masao, and NAMBA Tsuneo , Tetrahedron, Volume 50, Issue 10, p.3081-3098, (1994) Abstract
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29A-01 Isolation of Human Intestinal Bacteria Capable of Transforming Rhein to Rhein Anthrone, Meselhy, Meselhy R. , 和漢医薬学会大会要旨集, Volume 15, p.19, (1998) Abstract
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Metabolism of safflor yellow B by human intestinal bacteria, Meselhy, M. R., KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Journal of natural products, Volume 56, Issue 1, p.39-45, (1993) Abstract
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Hopane-type saponins from Polycarpon succulentum growing in Egypt, Meselhy, Meselhy R., and Aboutabl El-Sayed A. , Phytochemistry, Volume 44, Issue 5, p.925-929, (1997) Abstract
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TINCTRMINE, A NOVEL Ca2+ ANTAGONIST N-CONTAINING QUINOCHALCONE C-GLYCOSIDE FROM CARTHAMUS TINCTORIUS L., Meselhy, Meselhy R., KADOTA Shigetoshi, Momose Yasunori, Hattori Masao, and NAMBA Tsuneo , Chemical and pharmaceutical bulletin, Volume 40, Issue 12, p.3355-3357, (1992) Abstract
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