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A
Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MURAKAMI Yukihisa, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Biological and Pharmaceutical Bulletin, Volume 22, Issue 5, p.491-497, (1999) Abstract
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Potent anticonvulsant paeonimetabolin-I derivatives obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MOHAMED Tarek A., MAHFOUZ Nadia M., and EL-GENDY Mahmoud A. , Chemical and pharmaceutical bulletin, Volume 46, Issue 9, p.1486-1487, (1998) Abstract
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Effects of paeoniflorin derivatives on scopolamine-induced amnesia using a passive avoidance task in mice; structure-activity relationship, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, WATANABE Hiroshi, MUKARAMI Yukihisa, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Biological and Pharmaceutical Bulletin, Volume 21, Issue 11, p.1174-1179, (1998) Abstract
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New paeonilactone-A adducts formed by anaerobic incubation of paeoniflorin with Lactobacillus brevis in the presence of arylthiols, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Chemical and pharmaceutical bulletin, Volume 49, Issue 7, p.918-920, (2001) Abstract
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New oxypregnane glycosides from Caralluma penicillata, Abdel-Sattar, Essam, Meselhy Meselhy R., and Al-Yahya Mohammed Abdul-Aziz , Planta medica, Volume 68, Issue 05, p.430-434, (2002) Abstract
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Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells., Abdellatef, Amira A., Zhou Yue, Yamada Akane, Elmekkawy Sahar A., Kohyama Aki, Yokoyama Satoru, Meselhy Meselhy R., Matsuya Yuji, Sakurai Hiroaki, and Hayakawa Yoshihiro , Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Volume 140, p.111737, (2021) Abstract

Guggulsterone (GS) [4,17(20)-pregnadiene-3,16-dione], is the main active phytosterol constituent in guggul, the gum resin of Commiphora wightii (Arnott.) Bhand./Commiphora mukul Engl. tree, and is known for its medicinal effects. In this study, we report that GSD-1, a structurally-related synthetic GS derivative, strongly inhibits NF-κB activation induced by TNF-α. GSD-1 prevented the nuclear translocation of p65 through the blockade of IκBα degradation and p65 phosphorylation, and further inhibited the activation of upstream kinases, including transforming growth factor-β activated kinase 1 (TAK1), IκB kinase (IKK) α, and IKKβ. Furthermore, GSD-1 inhibited the cell-intrinsic activation of NF-κB, and exerted its direct anti-cancer and anti-metastatic effects in both murine and human breast cancer cell lines. This study demonstrated GSD-1 to be an attractive compound to target NF-κB activation that has potential for treating breast cancer growth and metastasis.

Iridoids from Phlomis aurea Decne growing in Egypt., Aboutabl, E. A., Meselhy M. R., and Afifi M. S. , Die Pharmazie, Volume 57, Issue 9, p.646-647, (2002) Abstract
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Phenolic constituents from Grevillea robusta, Ahmed, Amany S., Nakamura Norio, Meselhy Meselhy R., Makhboul Makhboul A., El-Emary Nasr, and Hattori Masao , Phytochemistry, Volume 53, Issue 1, p.149-154, (2000) Abstract
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Evaluation of the Anti-inflammatory and Antioxidant Activities of Selected Resin Exudates, Ali, Dalia E., Abdelrahman Rehab S., Gedaily Rania El A., Ezzat Shahira M., Meselhy Meselhy R., and Abdel-Sattar Essam , Tropical Journal of Natural Product Research, Volume 4, Issue 7, p.255-261, (2020)
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Pharmacokinetic study of paeoniflorin, paeonimetabolin-I and glycyrrhetic acid in humans after oral administration of paeony root, Glycyrrhiza and Shakuyaku-kanzo-to (Shao-Yao-Gan-Cao-Tang)., Bando, Miyuki, Shibahara Naotoshi, Shimada Yutaka, Meselhy Meselhy R., Akao Teruaki, Itoh Takashi, and Terasawa Katsutoshi , Journal of Traditional Medicines, Volume 17, Issue 1, p.26-33, (2000) Abstract
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Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation, Basu, Nikhil K., Kubota Shigeki, Meselhy Meselhy R., Ciotti Marco, Chowdhury Bhabadeb, Hartori Masao, and Owens Ida S. , Journal of Biological Chemistry, Volume 279, Issue 27, p.28320-28329, (2004) Abstract
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Sesquiterpenes from Cymbopogon proximus, El-Askary, Hesham I., Meselhy Meselhy R., and Galal Ahmed M. , Molecules, Volume 8, Issue 9, p.670-677, (2003) Abstract
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Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Tezuka Yasuhiro, Hattori Masao, Kakiuchi Nobuko, Shimotohno Kunitada, Kawahata Takuya, and Otake Toru , Phytochemistry, Volume 49, Issue 6, p.1651-1657, (1998) Abstract
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12-O-acetylphorbol-13-decanoate potently inhibits cytopathic effects of human immunodeficiency virus type 1 (HIV-1), without activation of protein kinase C, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , CHEMICAL AND PHARMACEUTICAL BULLETIN-TOKYO-, Volume 47, p.1346-1347, (1999) Abstract
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Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria, El-Mekkawy, Sahar, Meselhy M. R., Kawata Yukio, KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Planta medica, Volume 59, Issue 04, p.347-350, (1993) Abstract
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Inhibitory effects of egyptian folk medicines oh human immunodeficiency virus (HIV) reverse transcriptase, El-Mekkawy, Sahar, Meselhy Meselhy R., KUSUMOTO Ines Tomoco, KADOTA Shigetoshi, Hattori Masao, and NAMBA Tsuneo , Chemical and Pharmaceutical Bulletin, Volume 43, Issue 4, p.641-648, (1995) Abstract
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Natural Products as Antiviral Agents Natural Products as Antiviral Agents, 1-29, 1992, El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Chemical & pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002) Abstract
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Anti-HIV-1 phorbol esters from the seeds of Croton tiglium, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Phytochemistry, Volume 53, Issue 4, p.457-464, (2000) Abstract
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Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives, El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Chemical and pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002) Abstract
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Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii., El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita , Natural product research, 2013, Volume 27, Issue 2, p.146-54, (2013) Abstract

Three new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangambin, gugglsterol I, (E)-guggulsterone and (Z)-guggulsterone. Their structures were elucidated on the basis of different spectroscopic data. α-Glucosidase inhibitory effects of HSF and the isolated compounds were evaluated calorimetrically. The HSF showed significant α-glucosidase inhibitory effect [IC(50) value of 140 µg mL(-1) (p < 0.05)]. Under the assay conditions, diasesartemin (IC(50) = 60.6 ± 0.01 µM) was found to be more potent than the positive control, acarbose (IC(50) = 92.94 ± 0.01 µM); a known α-glucosidase inhibitor (p < 0.05). The IC(50) values of epi-mukulin and (Z)-guggulsterone were found to be 159.33 and 132.14 µM, respectively. Other compounds showed weak α-glucosidase inhibitory effects, <30% inhibition of the enzyme activity at 0.1 mg mL(-1).

Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii, El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita , Natural product research, Volume 27, Issue 2, p.146-154, (2013) Abstract
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Comparative Antioxidant Activities of Selected Apiaceous Plants, Emad, Ayat M., Ali Sherifa F., Meselhy Meselhy R., and Sattar Essam A. , Pharmacognosy Journal, Volume 11, Issue 6, p.1-6, (2019)
Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity., Emad, Ayat M., Ali Sherifa F., Abdel-Rahman Engy A., Meselhy Meselhy R., Farag Mohamed A., Ali Sameh S., and Abdel-Sattar Essam A. , Journal of food biochemistry, p.e13399, (2020) Abstract

In the present work, antioxidant activity, total phenolics (TP), and total flavonoids (TF) contents of aqueous and methanol extracts of celery were determined, in addition to untargeted metabolites profiling its methanol celery root extract (MCRE) via UPLC-MS. Although MCRE exhibited the lowest TPC and TFC levels, it presented the most potential hydroxyl radical quenching effect using electron paramagnetic resonance spin trapping technique. Treatment of Acetaminophen-induced hepatotoxicity (AAH) rats with MCRE lowered serum levels of AST, ALT, ALP, TNF-α, and IL-1β significantly. Additionally, MCRE significantly increased total antioxidant capacity (TAC) and glutathione (GSH) levels relative to AAH rats. Strikingly, Kaplan-Meier survival analysis of all groups revealed a 100% prevention of acetaminophen-induced mortality of rats by MCRE pretreatment (100 mg/kg/day). MCRE prevented AAH-associated severe weight loss and elicited normal behavior in the rescued rats. Our results suggest that pretreatment with MCRE can mitigate against overdosed acetaminophen-induced acute liver failure and warrant further investigations on the potential of postinjury intervention. PRACTICAL APPLICATIONS: Acetaminophen-induced hepatotoxicity (AAH) accounts for alerting numbers of overdose-related acute liver failure and liver transplant cases with increased morbidity and mortality rates. Currently proposed mechanisms implicate mitochondria-mediated oxidative stress and inflammation in the pathogenesis of AAH, which underline current interventions employing antioxidants to combat liver damage by over-dosed acetaminophen. The present work uncovers potent protective effects of some celery extracts (and their fractions) against acetaminophen-induced oxidative stress and inflammation. Treatment of rats with fatal liver injury with methanol extract of celery root significantly reduced secretion of liver enzymes and markedly decreased inflammatory as well as oxidative stress markers in these animals. This, in turn, rescued challenged rats exposed to fatal doses of acetaminophen completely, which establishes methanol extracts of celery roots as effective therapeutic intervention against AAH. The antioxidant capacity of the extracts was determined using EPR technique, and the secondary metabolites related to antioxidant activity were characterized via UPLC-MS.

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Alkaloids Self-Assembled Supramolecular Nanocapsules with Enhanced Antioxidant and Cytotoxic Activities., Fahmy, Sherif Ashraf, Issa Marwa Y., Saleh Basma M., Meselhy Meselhy Ragab, and Azzazy Hassan Mohamed El-Said , ACS omega, Volume 6, Issue 18, p.11954-11963, (2021) Abstract

Amphiphilic macrocycles, such as -sulfonatocalix[6]arenes (-SC6), have demonstrated great potential in designing synthetic nanovesicles based on self-assembly approaches. These supramolecular nanovesicles are capable of improving the solubility, stability, and biological activity of various drugs. In the present study, the biologically active harmala alkaloid-rich fraction (HARF) was extracted from . seeds. Ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC/ESI-MS) analysis of HARF revealed 15 alkaloids. The reversed-phase high-performance liquid chromatography (RP-HPLC) analysis revealed three peaks: peganine, harmol, and harmine. The HARF was then encapsulated in -SC6 nanocapsules employing a thin-film hydration approach. The designed nanocapsules had an average particle size of 264.8 ± 10.6 nm, and a surface charge of -30.3 ± 2.2 mV. They were able to encapsulate 89.3 ± 1.4, 74.4 ± 1.3, and 76.1 ± 1.7% of the three harmala alkaloids; harmine, harmol, and peganine; respectively. The drug release experiments showed the potential of the designed nanocapsules to release their cargo at a pH of 5.5 (typical of cancerous tissue). The IC values of HARF encapsulated in -SC6 (H/-SC6 nanocapsules) were 5 and 2.7 μg/mL against ovarian cancer cells (SKOV-3) and breast adenocarcinoma cells (MCF-7), respectively. The prepared nanocapsules were found to be biocompatible when tested on human skin fibroblasts. Additionally, the antioxidant activity of the designed nanocapsules was 5 times that of the free powder fraction; the IC of the H/-SC6 nanocapsules was 30.1 ± 1.3 μg/mL, and that of the HARF was 169.3 ± 7.2 μg/mL. In conclusion, encapsulation of alkaloid-rich fraction into self-assembled -SC6 significantly increases its antioxidant and cytotoxic activities.

New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits, m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., and Meselhy Meselhy R. , Pharmacognosy research, Volume 5, Issue 2, p.55, (2013) Abstract
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Chemical and biological study of Manilkara zapota (L.) Van Royen leaves (Sapotaceae) cultivated in Egypt, m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., Meselhy Meselhy R., and Shazly Amani H. , Pharmacognosy research, Volume 4, Issue 2, p.85, (2012) Abstract
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New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits., m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., and Meselhy Meselhy R. , Pharmacognosy research, 2013 Apr, Volume 5, Issue 2, p.55-9, (2013) Abstract

β-amyrin-3-(3'-dimethyl) butyrate, a new natural compound was isolated from the fruits of Manilkara zapota (L.) Van Royen, in addition to lupeol-3-acetate and 4-caffeoylquinic acid (cryptochlorogenic acid). The structures of these compounds were identified using different spectral methods (IR, MS, UV, (1)H-NMR, (13)C-NMR and 2D-NMR). The alcoholic and aqueous extracts of the unripe fruits, in addition to their aqueous homogenate exhibited antioxidant, antihyperglycemic and hypocholesterolemic activities.

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Diterpene acids from Conyza incana, Galal, Ahmed M., Abdel-Sattar Essam, El-Feraly Farouk S., Mossa Jaber S., Meselhy Meselhy R., KADOTA Shigetoshi, and NAMBA Tsuneo , Phytochemistry, Volume 48, Issue 1, p.159-163, (1998) Abstract
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Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum, GAO, Jiang Jing, MIN Byung Sun, Akao Teruaki, Meselhy Meselhy R., and Nakamura Norio , 和漢医薬学雑誌, Volume 18, Issue 4, p.154-160, (2001) Abstract
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Quinic acid derivatives from Artemisia annua L. leaves; biological activities and seasonal variation, H.I. El-Askary, S.S. Mohamed, El-Gohari H. M. A., Ezzat S. M., and Meselhy M. R. , South African Journal of Botany, Volume 128, p.200-208, (2020)
Inhibitory effect of component from Ganoderma lucidum on the growth of human immunodeficiency virus (HIV) and the protease activity, Hattori, Masao, El-Mekkawy S., and Meselhy M. R. , Proceedings of the 1st International Symposium on Ganoderma Lucidum in Japan, Mizuno T, Ide N and Hasegawa Y (eds), p.128-135, (1997) Abstract
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Guaianolides from Centaurea scoparia, Helal, Amr M., Nakamura Norio, Meselhy Meselhy R., El-Fishawy Ahlam M., Hattori Masao, and Mahran Gamal H. , Phytochemistry, Volume 45, Issue 3, p.551-554, (1997) Abstract
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Phenolics from Maytenus senegalensis, Hussein, Ghazi, Nakamura Norio, Meselhy Meselhy R., and Hattori Masao , Phytochemistry, Volume 50, Issue 4, p.689-694, (1999) Abstract
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Conversion of aconitine to lipoaconitine by human intestinal bacteria and their antinociceptive effects in mice, Kawata, Yukio, Cho-mei MA, Nakamura Norio, WANG Hong, NAMBA Tsuneo, SATOH Kazuya, and KURAISHI Yasushi , 和漢医薬学雑誌= Journal of traditional medicines, Volume 16, Issue 1, p.15-23, (1999) Abstract
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Intestinal injury can be effectively prevented by in gamma irradiated rats., Khayyal, Mohamed T., El-Baz Farouk K., Meselhy Meselhy R., Ali Gamila H., and El-Hazek Rania M. , Heliyon, Volume 5, Issue 5, p.e01814, (2019) Abstract

is one of the most common microalgae that is used as human food. It is isolated from the salty lakes in El-Fayoum and Lake of Bardawil-Sinai in Egypt and can withstand very high concentrations of salt: The potentiality of , a unicellular biflagellate green alga to protect against intestinal injury induced after radiation exposure was studied. was given orally in doses of 100 and 200 mg/kg to male Wistar rats for 5 days before exposure to 6 Gray (Gy) gamma radiation and continued for a further two days. Rats were sacrificed 24 h later and intestinal segments were dissected out. One segment was examined histologically and another was used to prepare homogenates to assess relevant biochemical parameters reflecting intestinal injury. Radiation exposure led to a rise in the histological damage score, an increase in tissue tumor necrosis factor (TNF-α), interleukin (IL-1β) and thiobarbituric acid reactive substances (TBARS) but a reduction in tissue reduced glutathione (GSH) and in serum citrulline. Pretreatment with either dose of effectively reduced the severity of intestinal mucositis induced by gamma radiation.

The 117th Annual Meeting of the Pharmaceutical Society of Japan, Sendai, March The 117th Annual Meeting of the Pharmaceutical Society of Japan, Sendai, March 29, 1994, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Biological & pharmaceutical bulletin, Volume 21, Issue 6, p.588-593, (1998) Abstract
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Metabolism and pharmacokinetics of orally administered saikosaponin b1 in conventional, germ-free and Eubacterium sp. A-44-infected gnotobiote rats, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Biological and Pharmaceutical Bulletin, Volume 21, Issue 6, p.588-593, (1998) Abstract
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Proc. Symp. Wakan-Yaku Proc. Symp. Wakan-Yaku 10, 103-108, 1999, Kida, Hiroaki, Akao Teruaki, Meselhy Meselhy Ragab, and Hattori Masao , Proc. Symp. Wakan-Yaku, Volume 10, p.103-108, (1999) Abstract
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Enzymes responsible for the metabolism of saikosaponins from Eubacterium sp. A-44, a human intestinal anaerobe, Kida, Hiroaki, Akao Teruaki, MESELHY Meselhy, and Hattori Masao , Biological and Pharmaceutical Bulletin, Volume 20, Issue 12, p.1274-1278, (1997) Abstract
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Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells., Kohyama, Aki, Yokoyama Rei, Dibwe Dya Fita, El-Mekkawy Sahar, Meselhy Meselhy R., Awale Suresh, and Matsuya Yuji , Bioorganic & medicinal chemistry letters, Volume 30, Issue 7, p.126964, (2020) Abstract

E- and Z-guggulsterones and nine guggulsterone derivatives (GSDs) were synthesized and evaluated for their preferential cytotoxicity against human PANC-1 cell in nutrient deprived medium utilizing antiausterity strategy. Among the synthesized compounds, GSD-1 and GSD-7 showed potent cytotoxicity against PANC-1 cells under nutrient-deprived conditions in a concentration dependent manner, with a PC value of 1.6 μM and 3.2 μM, respectively. The effect of GSD-1 and GSD-7 was further evaluated in a real time using live cell imaging. Both of these compounds altered PANC-1 cell morphology, leading to cell death at sub micromolar concentration range. GSD-1 and GSD-7 also inhibited PANC-1 cell colony formation in a concentration-dependent manner. GSD-1 and GSD-7 are lead structure for the anti-austerity drug development.

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