Publications

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2019
Intestinal injury can be effectively prevented by in gamma irradiated rats., Khayyal, Mohamed T., El-Baz Farouk K., Meselhy Meselhy R., Ali Gamila H., and El-Hazek Rania M. , Heliyon, Volume 5, Issue 5, p.e01814, (2019) Abstract

is one of the most common microalgae that is used as human food. It is isolated from the salty lakes in El-Fayoum and Lake of Bardawil-Sinai in Egypt and can withstand very high concentrations of salt: The potentiality of , a unicellular biflagellate green alga to protect against intestinal injury induced after radiation exposure was studied. was given orally in doses of 100 and 200 mg/kg to male Wistar rats for 5 days before exposure to 6 Gray (Gy) gamma radiation and continued for a further two days. Rats were sacrificed 24 h later and intestinal segments were dissected out. One segment was examined histologically and another was used to prepare homogenates to assess relevant biochemical parameters reflecting intestinal injury. Radiation exposure led to a rise in the histological damage score, an increase in tissue tumor necrosis factor (TNF-α), interleukin (IL-1β) and thiobarbituric acid reactive substances (TBARS) but a reduction in tissue reduced glutathione (GSH) and in serum citrulline. Pretreatment with either dose of effectively reduced the severity of intestinal mucositis induced by gamma radiation.

2018
Polyphenols LC-MS2 profile of Ajwa date fruit (Phoenix dactylifera L.) and their microemulsion: Potential impact on hepatic fibrosis, Nematallah, Khaled A., Ayoub Nahla A., Abdelsattar Essam, Meselhy Meselhy R., Elmazar Mohey M., El-Khatib Ahmed H., Linscheid Michael W., Hathout Rania M., Godugu Kavitha, and Adel Aya , Journal of Functional Foods, Volume 49, p.401-411, (2018) Abstract
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2013
New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits., m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., and Meselhy Meselhy R. , Pharmacognosy research, 2013 Apr, Volume 5, Issue 2, p.55-9, (2013) Abstract

β-amyrin-3-(3'-dimethyl) butyrate, a new natural compound was isolated from the fruits of Manilkara zapota (L.) Van Royen, in addition to lupeol-3-acetate and 4-caffeoylquinic acid (cryptochlorogenic acid). The structures of these compounds were identified using different spectral methods (IR, MS, UV, (1)H-NMR, (13)C-NMR and 2D-NMR). The alcoholic and aqueous extracts of the unripe fruits, in addition to their aqueous homogenate exhibited antioxidant, antihyperglycemic and hypocholesterolemic activities.

Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii., El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita , Natural product research, 2013, Volume 27, Issue 2, p.146-54, (2013) Abstract

Three new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangambin, gugglsterol I, (E)-guggulsterone and (Z)-guggulsterone. Their structures were elucidated on the basis of different spectroscopic data. α-Glucosidase inhibitory effects of HSF and the isolated compounds were evaluated calorimetrically. The HSF showed significant α-glucosidase inhibitory effect [IC(50) value of 140 µg mL(-1) (p < 0.05)]. Under the assay conditions, diasesartemin (IC(50) = 60.6 ± 0.01 µM) was found to be more potent than the positive control, acarbose (IC(50) = 92.94 ± 0.01 µM); a known α-glucosidase inhibitor (p < 0.05). The IC(50) values of epi-mukulin and (Z)-guggulsterone were found to be 159.33 and 132.14 µM, respectively. Other compounds showed weak α-glucosidase inhibitory effects, <30% inhibition of the enzyme activity at 0.1 mg mL(-1).

New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits, m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., and Meselhy Meselhy R. , Pharmacognosy research, Volume 5, Issue 2, p.55, (2013) Abstract
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Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii, El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita , Natural product research, Volume 27, Issue 2, p.146-154, (2013) Abstract
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2012
Chemical and biological study of Manilkara zapota (L.) Van Royen leaves (Sapotaceae) cultivated in Egypt, m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., Meselhy Meselhy R., and Shazly Amani H. , Pharmacognosy research, Volume 4, Issue 2, p.85, (2012) Abstract
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Lanostane-type triterpenes from the sporoderm-broken spores of Ganoderma lucidum, Ma, Bing-Ji, Zhou Yan, Ruan Yuan, Ma Jin-Chuan, Ren Wei, and Wen Chun-Nan , The Journal of antibiotics, Volume 65, Issue 3, p.165, (2012) Abstract
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2006
Comparative study of chemical constituents of rhubarb from different origins, Komatsu, Katsuko, Nagayama Yorinobu, Tanaka Ken, Ling Yun, Cai Shao-Qing, Omote Takayuki, and Meselhy Meselhy Ragab , Chemical and pharmaceutical bulletin, Volume 54, Issue 11, p.1491-1499, (2006) Abstract
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Development of a high performance liquid chromatographic method for systematic quantitative analysis of chemical constituents in rhubarb, Komatsu, Katsuko, Nagayama Yorinobu, Tanaka Ken, Ling Yun, Basnet Purusotam, and Meselhy Meselhy Ragab , Chemical and pharmaceutical bulletin, Volume 54, Issue 7, p.941-947, (2006) Abstract
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2005
Developing of anti-HIV agents from natural resources (Chemical & Pharmacological study), Meselhy, Meselhy Ragab, El-Mekkawy Sahar, Ma Chaomei, Nakamura Norio, TEWTRAKUL Supinya, and Hattori Masao , 和漢医薬学雑誌, Volume 22, Issue 1, p.116-128, (2005) Abstract
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2004
Aβ (25–35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins, Tohda, Chihiro, Matsumoto Noriaki, Zou Kun, Meselhy Meselhy R., and Komatsu Katsuko , Neuropsychopharmacology, Volume 29, Issue 5, p.860, (2004) Abstract
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Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation, Basu, Nikhil K., Kubota Shigeki, Meselhy Meselhy R., Ciotti Marco, Chowdhury Bhabadeb, Hartori Masao, and Owens Ida S. , Journal of Biological Chemistry, Volume 279, Issue 27, p.28320-28329, (2004) Abstract
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Simultaneous determination of triterpene saponins in ginseng drugs by high-performance liquid chromatography, Zhu, Shu, Zou Kun, Cai Shaoqing, Meselhy Meselhy Ragab, and Komatsu Katsuko , Chemical and pharmaceutical bulletin, Volume 52, Issue 8, p.995-998, (2004) Abstract
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2003
Constituents from Moghat, the roots of Glossostemon bruguieri (Desf.), Meselhy, Meselhy R. , Molecules, Volume 8, Issue 8, p.614-621, (2003) Abstract
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Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents, Meselhy, Meselhy R. , Phytochemistry, Volume 62, Issue 2, p.213-218, (2003) Abstract
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A new enzyme immunoassay for aconitine and its application to quantitative determination of aconitine levels in plasma, Tazawa, Takako, Zhao Huai-qing, Li Yan, Meselhy Meselhy Ragab, Nakamura Norio, Akao Teruaki, and Hattori Masao , Biological and Pharmaceutical Bulletin, Volume 26, Issue 9, p.1289-1294, (2003) Abstract
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Sesquiterpenes from Cymbopogon proximus, El-Askary, Hesham I., Meselhy Meselhy R., and Galal Ahmed M. , Molecules, Volume 8, Issue 9, p.670-677, (2003) Abstract
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2002
Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells, Tohda, Chihiro, Matsumoto Noriaki, Zou Kun, Meselhy Meselhy R., and Komatsu Katsuko , The Japanese Journal of Pharmacology, Volume 90, Issue 3, p.254-262, (2002) Abstract
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Dammarane-Type Saponins from Panax j aponicus and Their Neurite Outgrowth Activity in SK-N-SH Cells, Zou, Kun, Zhu Shu, Meselhy Meselhy R., Tohda Chihiro, Cai Shaoqing, and Komatsu Katsuko , Journal of natural products, Volume 65, Issue 9, p.1288-1292, (2002) Abstract
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Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives, El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Chemical and pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002) Abstract
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Iridoids from Phlomis aurea Decne growing in Egypt., Aboutabl, E. A., Meselhy M. R., and Afifi M. S. , Die Pharmazie, Volume 57, Issue 9, p.646-647, (2002) Abstract
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Metabolism and pharmacokinetics of paeoniflorin, a bioactive component from Peony roots, Meselhy, Meselhy R., and Hattori Masao , 和漢薬研究所年報, Volume 28, p.3-13, (2002) Abstract
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Natural Products as Antiviral Agents Natural Products as Antiviral Agents, 1-29, 1992, El-Mekkawy, Sahar, Meselhy Meselhy Ragab, Abdel-Hafez Atef Abdel-Monem, Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Chemical & pharmaceutical bulletin, Volume 50, Issue 4, p.523-529, (2002) Abstract
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New oxypregnane glycosides from Caralluma penicillata, Abdel-Sattar, Essam, Meselhy Meselhy R., and Al-Yahya Mohammed Abdul-Aziz , Planta medica, Volume 68, Issue 05, p.430-434, (2002) Abstract
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2001
Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum, GAO, Jiang Jing, MIN Byung Sun, Akao Teruaki, Meselhy Meselhy R., and Nakamura Norio , 和漢医薬学雑誌, Volume 18, Issue 4, p.154-160, (2001) Abstract
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The heterocyclic ring fission and dehydroxylation of catechins and related compounds by Eubacterium sp. strain SDG-2, a human intestinal bacterium, Wang, Li-Quan, Meselhy Meselhy Ragab, Li Yan, Nakamura Norio, MIN Byung-Sun, QIN Guo-Wei, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 49, Issue 12, p.1640-1643, (2001) Abstract
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Human intestinal Bacteroides spp. RHEIN-I and RHEIN-II capable of transforming rhein to rheinanthrone, induce rhein-dependent diarrhea in rats, Meselhy, Meselhy Ragab, Nishimoto Eri, Akao Teruaki, and Hattori Masao , J Trad Med, Volume 18, Issue 4, p.169-176, (2001) Abstract
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In vivo Antiviral Activity of Stephania cepharantha against Herpes Simplex Virus Type‐1, ari Nawawi, As', Nakamura Norio, Meselhy Meselhy R., Hattori Masao, Kurokawa Masahiko, Shiraki Kimiyasu, Kashiwaba Noriaki, and Ono Minoru , Phytotherapy research, Volume 15, Issue 6, p.497-500, (2001) Abstract
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New paeonilactone-A adducts formed by anaerobic incubation of paeoniflorin with Lactobacillus brevis in the presence of arylthiols, Abdel-Hafez, Atef A., Meselhy Meselhy R., Nakamura Norio, Hattori Masao, EL-GENDY Mahmoud A., MAHFOUZ Nadia M., and MOHAMED Tarek A. , Chemical and pharmaceutical bulletin, Volume 49, Issue 7, p.918-920, (2001) Abstract
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Transformation of shikonin by a cell-free extract of Eubacterium sp. A-44, a human intestinal bacterium, Meselhy, Meselhy R., Nishimoto Eri, Akao Teruaki, and Hattori Masao , (2001) Abstract
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2000
Anti-HIV-1 phorbol esters from the seeds of Croton tiglium, El-Mekkawy, Sahar, Meselhy Meselhy R., Nakamura Norio, Hattori Masao, Kawahata Takuya, and Otake Toru , Phytochemistry, Volume 53, Issue 4, p.457-464, (2000) Abstract
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Biotransformation of a C-Glycosylflavone, Abrusin 2"-O-β-D-Apioside, by Human Intestinal Bacteria, Li, Yan, Meselhy Meselhy R., Wang Li-Quan, Nakamura Norio, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 48, Issue 8, p.1239-1241, (2000) Abstract
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Cytotoxicity of shikonin metabolites with biotransformation of human intestinal bacteria, MIN, Byung-Sun, Meselhy Meselhy-R, Hattori Masao, Kim Hwan-Mook, and Kim Young-Ho , Journal of microbiology and biotechnology, Volume 10, Issue 4, p.514-517, (2000) Abstract
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Four mono-tetrahydrofuran ring acetogenins, montanacins BE, from Annona montana, Wang, Li-Quan, Nakamura Norio, Meselhy Meselhy R., Hattori Masao, ZHAO Wei-Min, CHENG Kin-Fai, YANG Ren-Zhou, and QIN Guo-Wei , Chemical and pharmaceutical bulletin, Volume 48, Issue 8, p.1109-1113, (2000) Abstract
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Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone, Wang, Li-Quan, Meselhy Meselhy R., Li Yan, QIN Guo-Wei, and Hattori Masao , Chemical and pharmaceutical bulletin, Volume 48, Issue 11, p.1606-1610, (2000) Abstract
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Pharmacokinetic study of paeoniflorin, paeonimetabolin-I and glycyrrhetic acid in humans after oral administration of paeony root, Glycyrrhiza and Shakuyaku-kanzo-to (Shao-Yao-Gan-Cao-Tang)., Bando, Miyuki, Shibahara Naotoshi, Shimada Yutaka, Meselhy Meselhy R., Akao Teruaki, Itoh Takashi, and Terasawa Katsutoshi , Journal of Traditional Medicines, Volume 17, Issue 1, p.26-33, (2000) Abstract
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Phenolic constituents from Grevillea robusta, Ahmed, Amany S., Nakamura Norio, Meselhy Meselhy R., Makhboul Makhboul A., El-Emary Nasr, and Hattori Masao , Phytochemistry, Volume 53, Issue 1, p.149-154, (2000) Abstract
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