New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits.,
m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., and Meselhy Meselhy R.
, Pharmacognosy research, 2013 Apr, Volume 5, Issue 2, p.55-9, (2013)
Abstractβ-amyrin-3-(3'-dimethyl) butyrate, a new natural compound was isolated from the fruits of Manilkara zapota (L.) Van Royen, in addition to lupeol-3-acetate and 4-caffeoylquinic acid (cryptochlorogenic acid). The structures of these compounds were identified using different spectral methods (IR, MS, UV, (1)H-NMR, (13)C-NMR and 2D-NMR). The alcoholic and aqueous extracts of the unripe fruits, in addition to their aqueous homogenate exhibited antioxidant, antihyperglycemic and hypocholesterolemic activities.
Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii.,
El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita
, Natural product research, 2013, Volume 27, Issue 2, p.146-54, (2013)
AbstractThree new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangambin, gugglsterol I, (E)-guggulsterone and (Z)-guggulsterone. Their structures were elucidated on the basis of different spectroscopic data. α-Glucosidase inhibitory effects of HSF and the isolated compounds were evaluated calorimetrically. The HSF showed significant α-glucosidase inhibitory effect [IC(50) value of 140 µg mL(-1) (p < 0.05)]. Under the assay conditions, diasesartemin (IC(50) = 60.6 ± 0.01 µM) was found to be more potent than the positive control, acarbose (IC(50) = 92.94 ± 0.01 µM); a known α-glucosidase inhibitor (p < 0.05). The IC(50) values of epi-mukulin and (Z)-guggulsterone were found to be 159.33 and 132.14 µM, respectively. Other compounds showed weak α-glucosidase inhibitory effects, <30% inhibition of the enzyme activity at 0.1 mg mL(-1).
New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits,
m Fayek, Nesrin, Monem Azza Abdel R., Mossa Mohamed Y., and Meselhy Meselhy R.
, Pharmacognosy research, Volume 5, Issue 2, p.55, (2013)
Abstractn/a
Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii,
El-Mekkawy, Sahar, Meselhy Meselhy R., Nkobole Nolitha, and Lall Namrita
, Natural product research, Volume 27, Issue 2, p.146-154, (2013)
Abstractn/a