@article {204850,
	title = {Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells.},
	journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
	volume = {140},
	year = {2021},
	pages = {111737},
	abstract = {<p>Guggulsterone (GS) [4,17(20)-pregnadiene-3,16-dione], is the main active phytosterol constituent in guggul, the gum resin of Commiphora wightii (Arnott.) Bhand./Commiphora mukul Engl. tree, and is known for its medicinal effects. In this study, we report that GSD-1, a structurally-related synthetic GS derivative, strongly inhibits NF-κB activation induced by TNF-α. GSD-1 prevented the nuclear translocation of p65 through the blockade of IκBα degradation and p65 phosphorylation, and further inhibited the activation of upstream kinases, including transforming growth factor-β activated kinase 1 (TAK1), IκB kinase (IKK) α, and IKKβ. Furthermore, GSD-1 inhibited the cell-intrinsic activation of NF-κB, and exerted its direct anti-cancer and anti-metastatic effects in both murine and human breast cancer cell lines. This study demonstrated GSD-1 to be an attractive compound to target NF-κB activation that has potential for treating breast cancer growth and metastasis.</p>
},
	author = {Abdellatef, Amira A and Zhou, Yue and Yamada, Akane and Elmekkawy, Sahar A and Kohyama, Aki and Yokoyama, Satoru and Meselhy, Meselhy R and Matsuya, Yuji and Sakurai, Hiroaki and Hayakawa, Yoshihiro}
}
