@article {164510,
	title = {Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii.},
	journal = {Natural product research},
	volume = {27},
	year = {2013},
	month = {2013},
	pages = {146-54},
	abstract = {<p>Three new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangambin, gugglsterol I, (E)-guggulsterone and (Z)-guggulsterone. Their structures were elucidated on the basis of different spectroscopic data. α-Glucosidase inhibitory effects of HSF and the isolated compounds were evaluated calorimetrically. The HSF showed significant α-glucosidase inhibitory effect [IC(50) value of 140 {\textmu}g mL(-1) (p \&lt; 0.05)]. Under the assay conditions, diasesartemin (IC(50) = 60.6 {\textpm} 0.01 {\textmu}M) was found to be more potent than the positive control, acarbose (IC(50) = 92.94 {\textpm} 0.01 {\textmu}M); a known α-glucosidase inhibitor (p \&lt; 0.05). The IC(50) values of epi-mukulin and (Z)-guggulsterone were found to be 159.33 and 132.14 {\textmu}M, respectively. Other compounds showed weak α-glucosidase inhibitory effects, \&lt;30\% inhibition of the enzyme activity at 0.1 mg mL(-1).</p>
},
	keywords = {Analysis of Variance, Commiphora, Glycoside Hydrolase Inhibitors, Hexanes, India, Inhibitory Concentration 50, Methanol, Molecular structure, Phytosterols, Plant Extracts, Plant Gums, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet},
	issn = {1478-6427},
	doi = {10.1080/14786419.2012.662651},
	author = {El-Mekkawy, Sahar and Meselhy, Meselhy R and Nkobole, Nolitha and Lall, Namrita}
}
