Medical Sector

Citation:

YA, L., S. AM, S. S, and A. AI, "Expression Signature of MicroRNA-181-a Reveals its Crucial Rule in the Pathogenesis of Paediatric Systemic Lupus Erythematosus", Clin Exp Rheumatol, 2011.

Abstract:

Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disease manifested by self-reactive antibodies due to failure of selection in both B and T lymphocytes leading to immune intolerance accompanied by increased rate of apoptosis and deficiency in the clearance of the apoptotic cells. Micro RNAs regulate posttranscriptional gene expression and have been recently identified to regulate cellular differentiation, establishing immunological tolerance and are involved in the pathogenesis of several diseases. miR-181-a, expressed in haematopoietic cell lineage, has shown to be an important modulator of B and T cell differentiation, maturation and function. This study aims to identify the expression signature of miR-181-a in the peripheral blood of paediatric SLE and its regulatory effect on the consequent expression of its target gene PCAF.

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