Medical Sector

Citation:

Ali, S. M. H., N. E. - D. Tawfik, and R. M. El-Nashar, Construction and Performance Characteristics of New Ion Selective Electrodes Based on Carbon Nanotubes for Determination of Meclofenoxate Hydrochloride and Selegiline Hydrochloride, , Egypt, Cairo University, 2012.

Thesis Type:

Abstract:

The presented thesis describes the preparation and investigation of the
performance characteristics of new plastic membrane electrodes, carbon paste
electrodes and carbon nanotubes chemically modified carbon paste electrodes for
potentiometric determination of meclofenoxate hydrochloride (MecloCl) and
selegiline hydrochloride (SelCl). In these electrodes, the active element is
polyvinyl chloride (PVC) membrane as in case of plastic membrane electrodes that
plasticized with dioctyl adipate (DOA) containing an ion-exchanger of the
investigated drug with phosphomolybdic acid (PMA) or phosphotungstic acid
(PTA). Carbon paste electrodes presented low cost and easy construction by
simple mixing of graphite powder with dioctyladipate (DOA) as a plasticizer and
an ion-exchanger of the investigated drugs with phosphomolybdic acid (PMA) or
phosphotungstic acid (PTA). The same procedure is done for carbon nanotubes
chemically modified carbon paste electrodes with addition certain amount of
multi-wall carbon nanotubes which have excellent effect for improving the
performance characteristics of the studied electrodes for determination the
investigated drugs. Carbon nanotubes chemically modified carbon paste electrodes
have better conductivity, higher potential responses, faster response time, longer
operational lifetime and wider linear concentration range than carbon paste
electrodes due to carbon nanotubes possess unique geometric, mechanical,
electronic, and chemical properties as high mechanical strength, high electrical
conductivity, high thermal conductivity and high surface area.