Medical Sector

Citation:

El-Rahman, M. K. A., M. G. El-Bardicy, M. Y. Salem, N. Morcos, and A. El-Kosasy, Analytical and Stability Studies on some Drugs Affecting the Muscloskeletal System, , Egypt, Cairo University, 2012.

Thesis Type:

Abstract:

Most pharmaceutical compounds are subjected to some degradation with the
subsequent partial or even complete loss of pharmacological activity or the
conversion into harmful or toxic substances. A stability indicating procedure may
be defined as a procedure that affords selective determination of a drug in presence
of its degradation products. This work is concerned with the quantitative
determination of the intact molecules of some for some drugs affecting the
musculoskeletal system, namely, diacerein, neostigmine bromide, allopurinol,
benzbromarone and orphenadrine citrate in raw materials, in presence of their
degradation products and in their pharmaceutical dosage forms using different
analytical techniques. Simple spectrophotometric, ion-selective electrode based
potentiometric and chromatographic methods were developed for the stability
indicating determination of diacerein, neostigmine bromide, orphenadrine citrate
and for the analysis of a mixture of allopurinol and benzbromarone.