Analysis of Selected C.V.S. Acting Drugs

Citation:
Hassan, S. A. E. - M., Badr El-Dean Abd El-Haleam El-Zeany, H. W. Darwish, and M. Y. Salem, Analysis of Selected C.V.S. Acting Drugs, , Egypt, Cairo University, 2013.

Thesis Type:

M.Sc Thesis

Abstract:

This thesis is concerned with the analysis of four selected drugs of the CVS
acting drugs namely Amlodipine besylate, Atorvastatin calcium, Valsartan and
Hydrochlorothiazide. In this work, different analytical techniques were applied for
the simultaneous quantitative determination of Amlodipine besylate and
Atorvastatin calcium in their laboratory prepared mixtures and in their tablet
dosage form using spectrophotometric methods. Stability study was carried out on
Amlodipine besylate and Atorvastatin calcium and stability indicating methods
were developed for the determination of both drugs in the presence of their acidic
degradation products using chemometric methods. Different analytical techniques
were applied for the simultaneous quantitative determination of Amlodipine
besylate, Valsartan and Hydrochlorothiazide in their laboratory prepared mixtures
and in their tablet dosage form using spectrophotometric, chemometric and
chromatographic methods. The aim of the present work was the development of
analytical procedures which would be feasible, sensitive and specific for the
determination of the studied drugs in their laboratory prepared mixtures and their
pharmaceutical dosage forms and Amlodipine besylate and Atorvastatin calcium
in the presence of their acidic degradation products.

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