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2006
Amal A. Khalil, G. A., El-Samman, S. E. Abo-Abdou, and H. M. Nasar, Coping Strategies of Adolescents Having Sensory Disability in Port Said, , vol. 5, issue 1, 2006. Abstractcu_pdf.pdf

The study aimed to identify coping strategies used by adolescents with visual or hearing disability. This study was carried out two governmental schools for blind and deaf in Port Said, the sample of 75 disabled adolescents. The data was collected using a structured questionnaire and a coping scale to identify coping strategies used by disabled and communication problems with family member and others. Most of blind and deaf adolescents cope with their disability by using problem - focused strategies especially active role. Moreover, more than half of them used day dream as a way of emotional focused coping. The study recommended that schools must have at least one class for sensory disabled children to allow them to interact with other normal children. The nurse can support and participate in the problem - solving process by providing information, discussing alternative choice and assisting disabled adolescents to identify and test possible solution to their problems. Also the nurse must plan and implement rehabilitation program to disabled adolescents and their families about coping strategies to solve their problems.

2007
Ahmed, E. M., Appraisal of Pain Perception among Nurses who are Working with Hospitalized Preschool Age Children, , vol. 36, issue 1, 2007. Abstractcu_pdf.pdf

Pain is one of the major physical and psychological stressors for children. The preschool age children like the rest of humanity can experience pain. Children's pain management has been found to be problematic and in need of improvement. The aim of the study was to appraise pain perception among nurses who are working with hospitalized preschool age children at Cairo University pediatric Hospital and El Monira Pediatric Hospital. A descriptive design was utilized in this study. A total sample was 100 nurses who had work in medicine units in pediatric hospitals at the time of collecting data. Two tools were used to collect the required data, the structured questionnaire sheet which include pertinent data regarding the socio - demographic characteristics of nurses and their knowledge about pain in hospitalized preschool age child. The second tool was pain perception scale. The study results revealed that nearly fifth of nurses (22%) had good level of knowledge, nurses who had fair and poor level of knowledge about pain in children were 34% and 44% respectively. Less than half of nurses (48%) had acceptable level of perception, 44% had poor level, and only 8% had high level of perception. It was obviously that, there was a statistical significant positive correlation between nurses' knowledge and perception regarding pain in preschool aged children. The present study recommended that, periodic and continues in services training programs for nurses about pain assessment and management should be done, based on the latest research findings and innovations in the area of pediatric pain.

Abd-Rabou, S., and N. A. Hani, "Length of Stay, Outcome and Nosocomial Infection among Neonates Admitted to the Neonatal Intensive Care Unit in El-Karak Governmental Hospital, Jordan", The New Egyptian Journal of Medicine, vol. 36, issue 1, 2007. Abstractcu_pdf.pdf

The current study utilized a descriptive prospective cohort research design, aiming to identify and describe the determinants length of stay and outcome, and to study the epidemiological pattern and determinants of nosocomial infection among neonates admitted to the neonatal intensive care unit (NICU) in El-Karak Governmental Hospital, Jordan. A total number of 135 neonates admitted to the NICU during the period from January to December 2004 were constituted the subjects of the present study. The required data were obtained through a pre-designed, pre-coded neonatal profile sheet constructed by the researchers after reviewing the relevant literature. The study results revealed that, the highest percentage of neonates stayed from two to seven days in the unit. The majority of the neonates were discharged alive from the unit. The mortality rate among neonates was 14%. Almost two fifths of the neonates suspected to have sepsis on admission, while less than fifth of them acquired sepsis during their hospital stay. There were highly statistically significant relationships between the length of stay of the neonates and their health problems and birth weight, highly statistically significant relationships were found between the hospital outcome of the neonates and their health problems, gestational age and birth weight. There were a statistically significant relationship between the occurrence of nosocomial infection and the birth weight of the neonates. The study recommended that, staff development programs should be developed based on need assessment in order to upgrade physicians’ and nurses’ knowledge and performance regarding the application of the infection control measures in the NICUs.

2008
Metwally, S. M., N. A. Mahgoub, Z. A. E. - H. Othman, and M. M. El-Kayal, Effect of Burden and Stigma of Mental Illness on Expressed Emotion of Families of Schizophrenic Patients, , vol. 76, issue 2, 2008. Abstractcu_pdf.pdf

"Expressed emotion" of relatives of schizophrenic patients is an important indicator of relapse in schizophrenia. Objective: The present study aimed to explore the effect of stigma of mental illness and burden of care-given of families of schizophrenic patients on their level of "expressed emotion". Design: A descriptive exploratory design was applied. Setting: This study was conducted at two psychiatric outpatient clinics in Banha Governmental Hospital for Mental Health and Zagazig University Hospitals. Sample: A purposeful sample of 100 schizophrenic patients' caregivers who accompany their patients. Results: Results of this study revealed that there were highly significant positive correlations between expressed emotion, family burden and stigma of mental illness. It is concluded that stigma of mental illness increases feelings of stress among caregivers leading to the experience of great burden. Increase feelings of stress and burden result in high expressed emotion in those caregivers. High expressed emotion in families caring for schizophrenic patients increases relapse of patients' mental disease.

Fattah, M. A. E. A. E. H., and F. A. Abed, Impact of the Staff nurses – Physicians Interdisciplinary Communication on the Quality of Nursing Care Performance Provided by the Staff Nurses ii, Critical care Medicine Departments at El-Manial University Hospital, Cairo University, , vol. 38, issue 2, 2008. Abstractcu_pdf.pdf

Communication and collaboration between nursing and medicine can have a profound effect on workplace environment and patient care. Communication between health care nurse-physician accounts for the major part of the information flow in health care system. Within intensive care units, 2% of the activity consists of verbal communication between nurses and doctors. So the present study aimed at identifying the impact of the staff nurses – physicians ' interdisciplinary communication on the quality of nursing care performance provided by the staff nurses in critical care medicine units at El-Manial University Hospital, Cairo University. The present study was based on one main question that: Is there a relationship between the staff nurses –physicians ' interdisciplinary communication and the quality of nursing care performance provided by the staff nurses in critical care units?. The present study took place in the departments of Critical Care medicine at El- Manial university hospital, Cairo University. The study sample consisted of (56) staff nurses. Data were collected through utilizing the following tools; The First questionnaire contained two sections, one related to demographic information which includes information on various demographic characteristics, the Second section was the interdisciplinary Collaboration' questionnaire developed by Shorten and colleagues (1994), The scale consists of (74) items and the second tool was the Quality of nursing care performance appraisal scale (QNCPA) adopted by Remington in Waltz& Strrik (1990). The scale consists of (38) items of nursing skills and procedures which used in the critical care units. The study concluded that Nurses - physicians communications were significantly correlated with the quality of nursing care performance provided by the staff nurses. Nurses-physicians interdisciplinary communication was significantly correlated with the participants who were females, of older age and more experienced. The study recommended that set up collaborative practice teams (CPTs); multidisciplinary health care teams aimed to ensure that quality, cost-effective, research-based care is provided to patients& position of interdisciplinary team manager should be created by the organization to ensure timely communication among all members including the patient and the patient's family.

2009
Elsamman, G., and N. E. kateb, Effect of Exercise on Physical Status of Children with Cancer Receiving Chemotherapy in the National Cancer Institute Egypt, , vol. 40, issue 3, 2009. Abstractcu_pdf.pdf

Physical exercise improve prognosis of cancer. In addition exercise for a cancer patient undergoing treatment is essentially the same as exercise for healthy person. The aims of the study were to assess physical status and side-effects of chemotherapy of cancer children receiving chemotherapy, design and implement exercise program for them, and evaluate the effect of exercise on side effects of chemotherapy and the physical status of cancer children. Quasi experimental design was used. A purposeful sample composed from thirty one school age children with cancer admitted to the Pediatric oncology department at the National Cancer Institute, Cairo University. Three tools were used to collect the needed data: questionnaire sheet, observation sheet and patient records. Results showed that more than half of children were boys; the mean age was 8.2+2.9, years. Exercise did affect neither pulse nor respiratory rate, differences between before and after the program were minimal and not proved to be statistically significant. There were significant differences between before and after exercise regarding appetite, nausea, vomiting, activity and pain. On the other hand, difference between before and after exercise regarding fatigue and sleeping hours per day not proved to be statistically significant. The study concluded that children engagement in daily light exercises for short duration improved their physical status and reduced side effects of chemotherapy except fatigue. The study recommends that nursing intervention protocol for children receiving chemotherapy should include regular exercise. Exercise program for children must start from the beginning of treatment and go parallel with it.

Hamid, A. A. A. E., S. H. H. A. El-Aziz, and H. M. Gaafar, Effect of Rheumatic Heart Disease on Pregnancy Outcome among Pregnant Woman Attending Delivery at El Manial University Hospital, , vol. 1, issue 40, 2009. Abstract

Rheumatic heart disease (RHD) remains the most common cardiac condition in pregnancy. Aim of this study was to evaluate the maternal and neonatal outcomes of pregnancy associated with rheumatic heart disease. Design a descriptive correlational design was adopted in this study. Setting: Labor and delivery unit at El Mania) Maternity Hospital, Cairo University. Sample, A total of 60 pregnant women (30 RHD with single valve involvement & 30 normal, without medical disease) were recruited for this study. Tools. Three tools developed by researchers were used for data collection, interviewing questionnaire sheet; maternal and neonatal evaluation sheets. Procedure data collected), through three phases: 1) interviewing; 2) assessment and 3) evaluation. Results of the present study indicated that, no statistically significant differences between groups were found regarding sociodemographic characteristics. Mean age for, pregnant women in the RHD group was 27.50 ± 4,79 years Vs 25.,-'3,--'- 4.37 years for control group. More than one third (36.7%) in both groups cannot read and write. Mean of gestational age for RHD group was 37.83 ± 0.64 weeks gestation while, it was 39.16 ± 1.44 weeks gestation for control group. During labor, 43.3% in the RHD group had dyspnea and palpitation. More than half, (56.7%) of RJ'1D group delivered by caesarean section Vs 26.7% in the control group. Postpartum, 43.3% in the RHD group had a tonic uterus Vs 10% in the control group. Regarding neonatal outcome, at the fifth, minute 20% in RHD group had moderate asphyxia Vs 6.7% in the control group. Less than one, third of neonates in the RHD group was low birth weight Vs non in the control group. The study concluded that rheumatic heart disease is considered a risk factor for both maternal and neonatal morbidity. Recommendations: Construct a join cardio -obstetric clinic and close monitoring for the mother during the first .24 hours after delivery.

Mohame, H. E., G. A. E. - Samman, and E. H. El-Shaeer, "Effect of Structured Postnatal Education for Mothers on Neonatal Care and Early Detection of Neonatal Health Problems", The New Egyptian Journal of Medicine, vol. 40, issue 3, 2009. cu_pdf.pdf
2010
Khalil, M., "Direct contact of umbilical cord blood endothelial progenitors with living cardiac tissue is a requirement for vascular tube-like structures formation", J. Cell. Mol. Med, vol. 15, issue 9, pp. 1914-1926, 2010. Abstractcu_pdf.pdf

The umbilical cord blood derived endothelial progenitor cells (EPCs) contribute to vascular regeneration in experimental models of
ischaemia. However, their ability to participate in cardiovascular tissue restoration has not been elucidated yet. We employed a novel
coculture system to investigate whether human EPCs have the capacity to integrate into living and ischaemic cardiac tissue, and participate
to neovascularization. EPCs were cocultured with either living or ischaemic murine embryonic ventricular slices, in the presence
or absence of a pro-angiogenic growth factor cocktail consisting of VEGF, IGF-1, EGF and bFGF. Tracking of EPCs within the cocultures
was performed by cell transfection with green fluorescent protein or by immunostaining performed with anti-human vWF, CD31, nuclei
and mitochondria antibodies. EPCs generated vascular tube-like structures in direct contact with the living ventricular slices.
Furthermore, the pro-angiogenic growth factor cocktail reduced significantly tubes formation. Coculture of EPCs with the living
ventricular slices in a transwell system did not lead to vascular tube-like structures formation, demonstrating that the direct contact is
necessary and that the soluble factors secreted by the living slices were not sufficient for their induction. No vascular tubes were formed
when EPCs were cocultured with ischaemic ventricular slices, even in the presence of the pro-angiogenic cocktail. In conclusion, EPCs
form vascular tube-like structures in contact with living cardiac tissue and the direct cell-to-cell interaction is a prerequisite for their
induction. Understanding the cardiac niche and micro-environmental interactions that regulate EPCs integration and neovascularization
are essential for applying these cells to cardiovascular regeneration.

Khalil, M., "Direct contact of umbilical cord blood endothelial progenitors with living cardiac tissue is a requirement for vascular tube-like structures formation", J. Cell. Mol. Med, vol. 15, issue 9, pp. 1914-1926, 2010. Abstractcu_pdf.pdf

The umbilical cord blood derived endothelial progenitor cells (EPCs) contribute to vascular regeneration in experimental models of
ischaemia. However, their ability to participate in cardiovascular tissue restoration has not been elucidated yet. We employed a novel
coculture system to investigate whether human EPCs have the capacity to integrate into living and ischaemic cardiac tissue, and participate
to neovascularization. EPCs were cocultured with either living or ischaemic murine embryonic ventricular slices, in the presence
or absence of a pro-angiogenic growth factor cocktail consisting of VEGF, IGF-1, EGF and bFGF. Tracking of EPCs within the cocultures
was performed by cell transfection with green fluorescent protein or by immunostaining performed with anti-human vWF, CD31, nuclei
and mitochondria antibodies. EPCs generated vascular tube-like structures in direct contact with the living ventricular slices.
Furthermore, the pro-angiogenic growth factor cocktail reduced significantly tubes formation. Coculture of EPCs with the living
ventricular slices in a transwell system did not lead to vascular tube-like structures formation, demonstrating that the direct contact is
necessary and that the soluble factors secreted by the living slices were not sufficient for their induction. No vascular tubes were formed
when EPCs were cocultured with ischaemic ventricular slices, even in the presence of the pro-angiogenic cocktail. In conclusion, EPCs
form vascular tube-like structures in contact with living cardiac tissue and the direct cell-to-cell interaction is a prerequisite for their
induction. Understanding the cardiac niche and micro-environmental interactions that regulate EPCs integration and neovascularization
are essential for applying these cells to cardiovascular regeneration.

El–Moneem., D. S. E. –D. A., Effect of Acupressure on Chemotherapy Induced Nausea and Vomiting Among Cancer Patient, , vol. 1, issue 1, 2010. Abstractcu_pdf.pdf

Patients who receive chemotherapy perceive nausea and vomiting to be one of the most problematic outcomes of chemotherapy, even with the administration of a prophylactic anti-emetic protocol. Therefore, the purpose of the current study was to evaluate the effect of acupressure on chemotherapy induced nausea and vomiting among cancer patients. A convenient sample of 63 adult male and female patients who had one day dose of chemotherapy was recruited. The study setting was the public–free of charge chemotherapeutic outpatient of the National Cancer Institute, Cairo University. Three tools were used for data collection: 1) Sociodemographic and medical data sheet, 2) Visual Analogue scale, 3) Patient assessment sheet. Pressure on % the neiguan, pericardium 6 (P6) was performed for about 1- 3 times for 5 minutes each according to the patients' condition and need. The study results showed that there were statistically significant differences between the anti- emetic session, whereas patients received the anti-emetic only and the acupressure sessions, whereas patients received routine anti-emetic plus acupressure in relation to incidence of nausea and vomiting, frequency and amount of vomiting and severity of nausea and vomiting during the during July 2010 chemotherapeutic cycle. There were no statistically significant differences between 1st and 2nd acupressure sessions in relation to incidence of nausea, frequency and amount of vomiting and perceived severity scores of nausea and vomiting during chemotherapy administration. In addition the majority of patients signed on high effect of acupressure as an adjuvant with anti-emetic in controlling

Abdelsalam, Z., A. Abdel Rahman, Y. El Sayed, and F. Mossa, "Psychosocial Stressors and Self Efficacy among Adults Diagnosed with Epilepsy in Egypt", Egyptian Nursing Journal, vol. 1, issue 1, 2010. Abstractcu_pdf.pdf

The chronic illness of epilepsy imposes several psychosocial stressors on patients and influences their health-related behaviors. The disease requires substantial behavioral and psychosocial adjustments. The influence of psychosocial stressors exerted by epilepsy on a person's self-efficacy is not well documented, especially among the Egyptian patients. This study was conducted to identify the psychosocial stressors and self-efficacy among Egyptian patients with epilepsy. A sample of convenience of 100 patients with epilepsy was recruited from the Out-patient clinic in El-Abassia Mental Health Hospital in Cairo and El Manial University Hospital Out-patient Clinic for Epilepsy. Four tools were used to accomplish this study including sociodemographic and medical data sheet, Stressors Inventory for Persons with Epilepsy (SIPE), General Self-efficacy Scale (GSES), and Epilepsy Self-efficacy Scale (ESES). The investigator collected data through a semi-structured interview with each patient and his/her family member if available. Results revealed that patients with epilepsy had intermediate psychosocial stressors (75%) as well as intermediate self-efficacy (72%). Sixty five percent of the sample was diagnosed as grand-mat epilepsy In addition; the study revealed that the frequency of seizures was the most related element to the level of psychosocial stressors and self-efficacy beliefs. Accordingly, we recommended that psychiatric nurses should teach patients and their families about epilepsy and emphasize their need for medication compliance.

Beltagy, M. A. E., M. Aggag, and M. Kamal, "Role of intraoperative ultrasound in resection of pediatric brain tumors", Child's Nervous System, vol. 26, issue 9, pp. 1189-1193, 2010. CU-PDF
Ghani, R. M. A., A. Khalaf, A. Westergren, V. Berggren, and N. A. Fadeel, "A Structured Evidence-Based Approach to Decrease Cardiovascular Complications among Pregnant Woman with Rheumatic Disease: A Pilot Randomized Controlled Trial", Journal of Medicine and Biomedical Sciences, 2010. Abstractcu_pdf.pdf

Background: Recent reports from the developing world have documented rheumatic fever (RE) incidence rates as high as 206/100 000 and Rheumatic Heart Disease (RHD) prevalence rates as high as 18.6/1000. The high frequency of RHD in the developing world necessitates aggressive prevention and control measures. Aim: The aim of the study was to examine the effect of intensive antenatal follow up program on decreasing cardiovascular complications among rheumatic pregnant woman. Design: Randomized controlled trial. Setting: This study was conducted at El Kasr-EL Aini, maternity hospital- Cairo- University Hospitals. Sample: A total of 100 rheumatic pregnant women that attended the antenatal clinic at El Kasr-EL Aini, maternity hospital who could read and write, had functional class I and II cardiac disease, primigravida, nullipara with single fetus were recruited to this study and assigned randomly into two groups. Procedure: Women who met the inclusion criteria were interviewed and baseline assessment was done. The intervention was an intensive antenatal follow up program for decreasing cardiovascular complications among rheumatic pregnant woman. Patients in the study group (SG) were offered an intervention at three levels, basic, intermediate and comprehensive. Evaluation of the program was carried out in term of assessment of maternal and neonatal outcome. Results: There were several significant differences between the study group (SG) and control group (CG). In the SG, antepartum complications was less common, gestational age at birth was higher, postnatal hospital stay shorter, birth weight higher, more had vaginal deliveries with episiotomy, fewer had caesarean section, forceps deliveries and termination of pregnancy, and cardiac class
was better at follow up as compared to the CG. Conclusion: The difficult issues in pregnancy complications by cardiac disease are best managed through a team approach. Establishing a pre-pregnancy plan will foster a better therapeutic relationship between all parties and allow for better understanding of the patient’s beliefs regarding pregnancy, her disease and attitude towards medications.

2011
N, E. I. - K., E. - M. R, F. M, E. - H. A, M. YF, and E. - K. H., "Alagille Syndrome: Clinical And Ocular Pathognomonic Features", Trends in Urology & Men's Health in collaboration with Eur J Ophthalmol, 2011. Abstract

Aim: This study was carried out to determine the frequency of the clinical diagnostic criteria in patients with Alagille syndrome (AGS) in comparison to a group of infants with cholestasis and histologically proven neonatal hepatitis (NH). Special emphasis will be paid to the type and frequency of ocular manifestations.

Ahmed, W. A., "Antitumor Activity Induced by Crude Extract of Lentinus edodes Fungi in Human Cell Lines and Experimental Animals", Journal of American Science (2011), 2011. Abstract

Background: Genotoxicity and cytotoxicity of anticancer drugs to the normal cells is the major problem in cancer therapy and engender a risk of inducing secondary malignancies. A dose of anticancer drug which is sufficient to kill tumor cells is often toxic to the normal tissue and lead to many side effects, which in turn . limited treatment efficacy . Many epidemiological studies have suggested that midcinal plants can play a vital role in inhibiting genotoxicity and carcinogenicity of anticancer drugs to normal cells. Materials and Methods: Lentinus edodes a Chinese edible and medicinal mushroom was grown using submerged culture on different standard liquid media and different food wastes by products. Shiitake broth medium was the medium that showed the maximum biomass for both tested strains. Crude extract of L. edodes mycelia was tested in this study In vitro and in vivo. The in vitro cytotoxic activity of the crude extracts of mycelia of the two strains were examined on human breast cancer (MCF7) cell line using trypan blue exclusion assay and MTT cytotoxicity assay. Result and Discussions: The results showed that the crude extract of Lentinus edodes LC2141 inhibited the proliferation of MCF7 at high concentration with IC50 178.8?g/ml while Lentinus edodes LC202 extract inhibited the proliferation of MCF7 at high concentration with IC50 94.025?g/ml. Cytotoxicity of the crude extracts was tested also against EAC by using trypan blue exclusion assay. Viability increased by decreasing concentration. In vivo experiments, group treated with crude extract of Lentinus edodes LC2141 showed a decrease in tumor size while 4 out 9 mice showed complete tumor regression. Group treated with crude extract of Lentinus edodes LC202 showed a decrease in tumor size while 3 out of 9 mice showed complete tumor regression.

Al-Inany, H. G., and A. M. Abou-Setta, "Are all human-derived follicle-stimulating hormone products the same? A systematic review and meta-analysis using direct and adjusted indirect analyses, to determine whether Fostimon1 is more efficient than Metrodin-HP1", Gynecological Endocrinology, 2011. Abstract

Background: Randomized trials (RCTs) and systematic reviews have challenged the claim for superiority of recombinant follicle-stimulating hormone (recFSH) compared with human-derived FSH (hFSH). Even so, much of the evidence comes from unavailable products. If the efficacy of the currently available Fostimon1 is superior, the off-market Metrodin-HP1,then data from the latter should not be used, gauge of the former.

Aboutab, E. A., K.M.Meselhy, E. M. Elkhreisy, M. I. Nassar, and R. Fawzi, "Composition and Bioactivity of Essential Oils from Leaves and Fruits of Myrtus communis and Eugenia supra-axillaris (Myrtaceae) Grown in Egypt", Journal of Essential Oil Bearing Plants, 2011. Abstract

Comparative investigation of hydro-distilled essential oils from leaves (L) and fruits (F) of Myrtus communis (M) and Eugenia supra-axillaris (E) (Fam. Myrtaceae) grown in Egypt was carried out; including: yield, physical characteristics, chemical composition and certain bioactivities. GC-FID and GC-MS analyses revealed that the oil samples differ in composition and percentages of certain components. The total number of identified constituents was 23, 21, 21 and 17 in EL, EF, ML and MF oil samples; representing: 98.6% , 98.5% , 90.3% and 91.8% of the total oil composition, respectively. Oxygenated compounds were found dominant in EF, ML and MF oil samples, being 81.4%, 61.5% and 71.5%, respectively, and 13.5% in EL sample. All the oil samples appeared dominated by monoterpenoids, among which limonene (21.8%), eugenol (35.5%), 1,8-cineole (27.2% and 29.6%) are major in EL, EF, ML and MF, respectively. Sesquiterpenes are minors in all samples, comprising mainly: ?-humulene in the two leaf samples EL and ML; while ?-selinene and trans-caryophyllene recorded the highest sesquiterpenoid percentile for EF and MF samples; respectively. Certain bioactivities including: cytotoxicity asainst different tumor cell lines, antimicrobial, and antiwormal activity against Allolobophora caliginosa were evaluated and found variable in the leaves and fruits of the two plants.

Abdallah, O. M., and A. M. Badaweyey, "Derivative", International Journal of Industrial Chemistry, 2011.
Hassan, G. S., "Design and Synthesis of some Piperazinomethyl Benzofuran Derivatives and Preliminary Investigation of their Hypotensive Activity as ?1-adrenoreceptor antagonists", International Journal of Pharmacy and Pharmaceutical Sciences, 2011. Abstract

Some piperazinomethyl benzofuran derivatives substituted at 5-position with 4,5-dihydropyrazole 3-9, were designed and synthesized. Molecular modeling study using Accelrys Discovery Studio 2.1 software was performed by mapping the newly designed compounds to the alpha1-adrenoceptor (?1-ARs) antagonist hypothesis. Preliminary blind screening of the hypotensive activity using normotensive cats' method (in vivo) was evaluated and showed appreciable activity. In vitro vasodilatation activity on isolated thoracic aortic rings of male Wister rats for the most active compounds (3c and 7b) was evaluated. Compound 7b (IC50 = 0.21 mM) is more potent than prazosin (IC50 = 0.48 mM), while 3c showed equal potency (IC50 = 0.49 mM). The structural elucidations were clearly confirmed by spectroscopy data and elemental analysis. Preparative TLC technique was applied.

Moussa, B. A., R. I. El-Bagary, and Y. A. Al-Eryani, "Development and Validation of A Stability-Indicating Hplc Method for the Analysis of Desvenlafaxine Succinate in the Presence of its Acidic Induced Degradation Product in Bulk and Pharmaceutical Preparation", Journal of Chemical and Pharmaceutical Research, 2011. Abstract

A stability- indicating High Performance Liquid Chromatography (HPLC) method of analysis of desvenlafaxine suucinate ( DSV) in the presence of its acidic induced- degradation product in pure and pharmaceutical preparation had been developed and validated. The chromatographic conditions comprised of an isocratic reversed- phase separation on Discovery C18 column. Elution was carried out using acetonitrile: phosphate buffer pH 3.8 (50: 50 v/v) as a mobile phase at a flow rate of 0.7 ml/min and UV detection at 229 nm.