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Book Chapter
mostafa Goma, H., "Anesthetic Considerations of Brain Tumor Surgery", Diagnostic evaluation and imaging techniques: InTech Europe, 2011. AbstractCU-PDF

Mortality risk for elective brain tumor surgery surgery,

Eissa, S. S., N. M. El-Bolkainy, and M. S. Eissa, "Chapter 7: Schistosomasis and Bladder Cancer", Schistosomasis InTech Open access, Rijeka, InTech Europe, 2011. AbstractCU-PDF

Schistosomiasis also known as bilharziasis is a parasitic disease that dates back to antiquity. The ancient Egyptians, through settling and cultivating the Nile valley, were among the first to contract the disease. Thus, the main symptom hematuria was mentioned in Egyptian papyri (1500-1800 B.C.), and schistosome eggs were identified in Egyptian mummies through paleopathologic studies. In 1852, Theodor Bilharz, a German pathologist working in Cairo, discovered the worms in the portal circulation and was the first to describe the Pathology of the disease. Ferguson in 1911 was the first to report on the high frequency of bladder cancer in Egypt and to suggest an etiologic relation with urinary Schistosomiasis, a fact which is now generally accepted (Bolkainy & Chu 1981a). The aim of this article is to review the pathobiology of Schistosoma associated bladder cancer (SACB), describe the relationship between Schistiosomiasis and bladder cancer with respect to the mechanisms of carcinogenesis with emphasis on special features of SABC and recent methods of early detection.

Journal Article
Ezzat, B. A., and N. S. Korany, "-Prophylactic Effect of Green Tea and Nigella Sativa Extracts Against Fenitrothione- Induced Toxicity in Rat Parotid Gland", Archives of Oral Biology, vol. 56, issue 11, pp. 1339–1346, 2011. AbstractCU-PDF

Objective: The aim of the present study was to compare between two antioxidant treatments in prevention of fenitrothion induced toxicity on rat parotid salivary gland.

AA, A. E. - B., S. HF, and K. RM, "2-Hydroxypropyl-ß-Cyclodextrin Complex with Ketotifen Fumerate for Eye Drops Preparations", International Journal of Drug Delivery, vol. 3, issue 2, pp. 228-240, 2011. AbstractCU-PDF

Ketotifen fumerate ophthalmic solution is an antihistaminic drug. The aim of this study was to develop a novel aqueous ketotifen eye drop formulation containin ketotifen/2-Hydroxypropyl-?-cyclodextrin complex, which has the ability to enhance the solubility of the drug at the physiological pH (7.4), consequently decreasing the irritation to the eye.

AA, A. E. - B., S. HF, and K. RM, "2-Hydroxypropyl-ß-Cyclodextrin Complex with Ketotifen Fumerate for Eye Drops Preparations", International Journal of Drug Delivery , vol. 3, pp. 228-240, 2011. CU-PDF.pdf
Ezzat, Y., S. Sayed, W. Gaber, A. M. Mohey, and T. W. Kassem, "25-Hydroxy vitamin D levels and its relation to disease activity and cardiovascular risk factors in women with systemic lupus erythematosus", The Egyptian Rheumatologist, vol. 33, issue 4, pp. 195–201, 2011. AbstractCU-PDF

Aim of the work: To evaluate the associations of serum 25 hydroxy (OH) vitamin D [25(OH)D] levels with cardiovascular risk factors as well as disease activity in women with SLE.

Abdallaha, O. M., and A. M. Badaweyb, "78 Derivative- Ratio Spectrophotometric, Chemometric and HPLC Validated methods for Simultaneous Determination of Amlodipine and Atorvastatin in Combined Dosage Form", International Journal of Industrial Chemistry, vol. 2, issue 2, pp. 78-85, 2011. cu_pdf.pdf
Eissa, S., M. Swellam, I. M. El-Khouly, S. K. Kassim, H. Shehata, A. Mansour, M. Esmat, A. I. Nossier, M. A. Hamdy, N. M. Awad, et al., "Aberrant Methylation of RARb2 and APC Genes in Voided Urine as Molecular Markers for Early Detection of Bilharzial and Nonbilharzial Bladder Cancer", Cancer Epidemiol Biomarkers Prev; 20 (8): 1657, 2011. AbstractCU-PDF

Background: Bladder cancer cells illustrate major disruptions in their DNA methylation patterns as compared with normal ones. Authors aimed to identify epigenetic molecular markers in urine for early detection of bladder cancer. Materials and Methods: We retrospectively analyzed the methylation status

El-Beialy, A. R., M. S. Fayed, A. M. El-Bialy, and Y. A. Mostafa, "Accuracy and reliability of cone-beam computed tomography measurements: Influence of head orientation", American Journal of Orthodontics and Dentofacial Orthopedics, vol. 140, issue 2, pp. 157–165, 2011. AbstractCU-PDF

Introduction: The purpose of this research is to determine the accuracy and reliability of measurements obtained from 3-dimensional (3D) cone-beam computed tomography (CBCT) for different head orientations.

Molla, M. E. - M., A. R. El-Beialy, A. H. kandil, A. E. M. beialy, and A. yehya mostafa., "Accuracy and Reproducibility of Voxel Based Superimposition of Cone Beam Computed Tomography Models on the Anterior Cranial Base and the Zygomatic Arches", PloS One, vol. 6, issue 2, 2011. AbstractCU-PDF

Superimposition of serial Cone Beam Computed Tomography (CBCT) scans has become a valuable tool for three dimensional (3D) assessments of treatment effects and stability. Voxel based image registration is a newly developed semiautomated technique for superimposition and comparison of two CBCT scans.

Taher, A., M. S. Elalfy, K. A. Zir, S. Daar, A. A. Jefri, D. Habr, U. Kriemler-Krahn, A. El-Ali, B. Roubert, and A. El-Beshlawy, "Achieving treatment goals of reducing or maintaining body iron burden with deferasirox in patients with b-thalassaemia: results from the ESCALATOR study", European Journal of Haematology, vol. 87, pp. 349-354, 2011. AbstractCU-PDF

This analysis evaluated the effects of deferasirox on liver iron concentration in moderate and heavily iron-overloaded patients with ?-thalassaemia from the ESCALATOR trial (n = 231).

Fattouh, A. M., Y. A. Mansi, M. G. El-anany, A. A. El-kholy, and H. M. El-karaksy, "Acute Lower Respiratory Tract Infection Due to Respiratory Syncytial Virus in A Group of Egyptian Children Under 5 Years of Age", Italian Journal of Pediatrics, 2011. AbstractCU-PDF

Background and aim: Respiratory syncytial virus (RSV) is one of the most important causes of acute lower respiratory tract infections (ALRTI) in infants and young children. This study was conducted to describe the epidemiology of ALRTI associated with RSV among children ? 5 years old in Egypt.

Towab, A., A. S. M. Khalil, E. A. W. Osman, and Z. Mokhtar, "Age Differences in Reactivity to Daily Stressors: The Role of Personal Control", Journal of American Science, vol. 8, issue 12, 2012. cu_pdf.pdf
N, E. I. - K., E. - M. R, F. M, E. - H. A, M. YF, and E. - K. H., "Alagille Syndrome: Clinical And Ocular Pathognomonic Features", Trends in Urology & Men's Health in collaboration with Eur J Ophthalmol, 2011. Abstract

Aim: This study was carried out to determine the frequency of the clinical diagnostic criteria in patients with Alagille syndrome (AGS) in comparison to a group of infants with cholestasis and histologically proven neonatal hepatitis (NH). Special emphasis will be paid to the type and frequency of ocular manifestations.

Shaeer, K., and O. Shaeer, "Algorithm for the surgical management of obstructive azoospermia ‘Shaeer's algorithm’ and the prevalence of multiple-site obstruction", Human Andrology, vol. 1, issue 1, pp. 17–21, 2011. Abstract

Aim: Evaluation of a protocol for the management of seminal tract obstruction.

Patients and methods: Eighty infertile men with obstructive azoospermia were enrolled in this study. Intraoperative vasography pinpointed the site (or sites) of obstruction. According to the algorithm, single-site or multiple-site obstructions were managed by various combinations of epididymovasostomy, vasovasostomy, transurethral resection of the ejaculatory ducts, and pelviscrotal vasovasostomy.

Results: Cases (92.5%, 74 out of 80 patients) showed the appearance of spermatozoa in semen after surgery. The average count was 14 million/ml and the average motility was 40%. Simultaneous multiple-site obstruction was detected and managed in 32 out of 80 patients (40%).

Conclusion: The modest success rate for surgical repair of seminal tract obstruction may be attributable to missing or failure to manage multiple-site obstruction, which appears to be common. The proposed algorithm guides the surgeon to full restoration of patency of the seminal tract along its whole length on the basis of proper diagnostic and corrective measures.

DA, S., K. AM, B. E. RM, and M. SS., "Alloimmunization and Erythrocyte Autoimmunization in Transfusion-Dependent Egyptian Thalassemic Patients", J Pediatr Hematol Oncol, 2011. AbstractCU-PDF

Background: Alloimmunization to red blood cells' (RBCs) antigens and formation of autoantibodies against RBCs is a frequent complication among immunocompetent transfusion-dependent patients. Autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. The objective of this study was to evaluate the presence of alloantibodies and autoantibodies in regularly transfused ?-thalassemic patients and the factors influencing the development of alloantibodies.

Gad, G. F., H. A. Mohamed, and H. M. Ashour, "Aminoglycoside Resistance Rates, Phenotypes, and Mechanisms of Gram-negative Bacteria from Infected Patients in Upper Egypt", PLoS One., vol. 6, issue 2, 2011. AbstractCU-PDF

With the re-emergence of older antibiotics as valuable choices for treatment of serious infections, we studied the aminoglycoside resistance of Gram-negative bacteria isolated from patients with ear, urinary tract, skin, and gastrointestinal tract infections at Minia university hospital in Egypt. Escherichia coli (mainly from urinary tract and gastrointestinal tract infections) was the most prevalent isolate (28.57%), followed by Pseudomonas aeruginosa (25.7%) (mainly from ear discharge and skin infections). Isolates exhibited maximal resistance against streptomycin (83.4%), and minimal resistance against amikacin (17.7%) and intermediate degrees of resistance against neomycin, kanamycin, gentamicin, and tobramycin. Resistance to older aminoglycosides was higher than newer aminoglycoides. The most common aminoglycoside resistance phenotype was that of streptomycin resistance, present as a single phenotype or in combination, followed by kanamycin-neomycin as determined by interpretative reading. The resistant Pseudomonas aeruginosa strains were capable of producing aminoglycoside-modifying enzymes and using efflux as mechanisms of resistance. Using checkerboard titration method, the most frequently-observed outcome in combinations of aminoglycosides with ?-lactams or quinolones was synergism. The most effective combination was amikacin with ciprofloxacin (100% Synergism), whereas the least effective combination was gentamicin with amoxicillin (53.3% Synergistic, 26.7% additive, and 20% indifferent FIC indices). Whereas the studied combinations were additive and indifferent against few of the tested strains, antagonism was never observed. The high resistance rates to aminoglycosides exhibited by Gram-negative bacteria in this study could be attributed to the selective pressure of aminoglycoside usage which could be controlled by successful implementation of infection control measures.

El-Haddad, M., R. S. Ahmed, A. Al-Suhaibany, M. Al-Hazza, N. Al-Sanae, A. A. Al-Jabbar, S. Hamoud, L. Ashaary, S. Bazerbashy, and K. Balaraj, "Anal Canal Carcinoma Treatment Results: The Experience of A Single Institution", Radiotherapy and Oncology, 2011. Abstractcu_pdf.pdf

Background And Objectives: Prior to the mid-1980s, me treatment of choice for anal cancer was abdom-inoperineal resection. Currently, combined chemoradiation is the standard of care. Or objective was to analyze results of treatment for anal canal carcinoma treated with combined chemoradiation.

Hammady, M. R., R. F. Salam, and M. Nabeh, "ANTI CHROMATIN ANTIBODIES AS A MARKER OF LUPUS ACTIVITY & LUPUS NEPHRITIS", International Journal of Academic Research, vol. 3, issue 6, pp. 139, 2011. CU-PDF.pdf
Ezzat, W. M., H. M. Raslan, A. A. Aly, N. A. Emara, M. E. M. Menyawi, and A. Edrees, "Anti-Cyclic Citrullinated Peptide Antibodies as A Discriminating Marker Between Rheumatoid Arthritis and Chronic Hepatitis C-Related Polyarthropathy", Rheumatology International, vol. 31, issue 1, pp. 65-69, 2011. AbstractCU-PDF

Articular involvement is a frequent extrahepatic manifestation of hepatitis C virus (HCV) infection. The distinction between HCV-related polyarthropathy and true RA may be very diYcult, especially with recent onset RA before articular damage and erosions develop. The objective of the study is to assess the diagnostic utility of anti-CCP antibodies and compare it with that of rheumatoid factor (RF) in distinguishing between rheumatoid arthritis (RA) and HCV-related polyarthropathy. Anti-cyclic citrullinated peptide (CCP) antibodies and RF were determined in the sera of 30 patients with RA and 22 patients with HCV-related polyarthropathy. Anti-CCP antibodies were positive in 83.3% of patients with RA and in 4.5% in patients with HCV and polyarthropathy. RF was positive in 90% of RA patients and in 81.1% of HCV patients with polyarthropathy. The anti-CCP antibodies showed higher speciWcity for RA compared with RF (95.4 vs. 18.2%). However, the sensitivity of anti-CCP was comparable to that of RF (83.3 vs. 90%). In conclusions, anti-CCP antibodiesare reliable laboratory markers to diVerentiate between RA and HCV-related polyarthropathy.

Michel, C. G., D. I. Nesseem, and M. F. Ismail, "Anti-diabetic Activity and Stability Study of the Formulated Leaf Extract of Zizyphus Spina-Christi (L", Journal of Ethnopharmacology, vol. 133, issue 7, pp. 53-62, 2011. AbstractCU-PDF

Aim of the study: The present study aimed to evaluate the anti-diabetic activity of Zizyphus spina-christi leaf extract (200 mg/kg b.w.), plain and formulated in STZ-diabetic rats. Percentage yield of extracts, marker yield (christinin-A) and antihyperglycemic potencies, depending on seasonal variation were investigated. The chemical stability, study of storage conditions, shelf life T90 prediction of both plain extract and formulated soft gelatin capsules by accelerated studies were studied.

El-Ghazaly, M. A., R. R. A. Rashed, and M. T. Khayyal, "Anti-ulcerogenic Effect of Aqueous Propolis Extract and the Influence of Radiation Exposure", International Journal of Radiation Biology, vol. 87, issue 10, pp. 1045-1051, 2011. AbstractCU-PDF

Purpose: To study the effect of aqueous propolis extract (AEP) against indomethacin (Indo)-induced gastric ulcers in irradiated and non-irradiated rats.

El-Mahallawy, H. A., M. El-Wakil, M. M. Moneer, and L. Shalaby, "Antibiotic Resistance Is Associated With Longer Bacteremic Episodes and Worse", Pediatric Blood & Cancer, vol. 57, issue 2, pp. 283–288, 2011. CU-PDF
Greish, K., A. Ray, H. Bauer, N. Larson, A. Malugin, D. Pike, M. Haider, and H. Ghandehari, "Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy", Journal of Controlled Release, vol. 151, issue 3, pp. 263–270, 2011. AbstractCU-PDF

Tumor progression is dependent on neoangiogenesis for blood supply. Neovasculature over-express ?v?3 integrins which recognize the Arg-Gly-Asp (RGD) sequence in the extracellularmatrix.N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers containing side chains terminated in cyclic RGD analogs such as RGDfK show increased accumulation in prostate tumors. Geldanamycin and their derivatives (e.g., aminohexylgeldanamycin (AH-GDM)) are benzoquinone ansamycins that have both antiangiogenic and antitumor activity. In this work the antiangiogenic and antitumor activities of targetable HPMA copolymer-RGDfK-AH-GDM conjugates were compared with nontargetable systems in vitro and in vivo. Copolymer-drug conjugates containing RGDfK in the side chains showed superior activity against endothelial and prostate cancer cell lines in vitro, aswell as higher inhibition of angiogenesis in vivo. At equimolar doses of the drug, the RGDfK containing conjugates showed significantly higher antitumor activity in nude mice bearing DU-145 human prostate cancer xenografts. These findings suggest the utility of HPMA copolymer-RGDfK conjugates for targeted delivery of geldanamycin analogs with a dual mode of action.

Ghorab, M. M., F. A. Ragab, H. I.Heba, and R. M.El-Hazek, "Anticancer and radio-sensitizing evaluation of some new thiazolopyrane and thiazolopyranopyrimidine derivatives bearing a sulfonamide moiety", European Journal of Medicinal Chemistry, vol. 46, issue 10, pp. 5120–5126, 2011. AbstractCU-PDF

Recently, it has been reported that compounds bearing a sulfonamide moiety posses many types of biological activities, including anticancer activity. There a variety of mechanisms for their anticancer activity, and the most prominent mechanism is the inhibition of carbonic anhydrase (CA) isozymes. The present work reports the synthesis of some new thiazolo[4,5-b]pyran and thiazolo[4,5-b] pyrano[2,3-d] pyrimidine derivatives bearing a sulfonamide moiety. The design of the structures of these compounds complies with the general pharmacophoric requirements for CA inhibiting anticancer drugs. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human breast cancer cell line ( MCF7) . Most of the screened compounds showed interesting cytoxic activity compared to doxorubicin as a reference drug. Three compounds showed higher cytotoxic activities than doxorubicin. These three compounds were evaluated again for their ability to enhance the cell killing effect of gamma radiation.