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.Ghorab, M. M., F. A. Ragab, H. A. Heiba, and A. A. Bayomi, "Utility of Methyl 2-Isothiocyanatobenzoate in the Synthesis of Some new Quinazoline Derivatives as Potential Anticancer and Raradiosensittising Agents", Arzneimittelforschung, 2011. Abstract

Novel quinazolines 4-11, 15 and triazoloquinazolines12-14 bearing biologically active sulfonamide moieties were synthesized . All the synthesized compounds were evaluated for their in vitro anticancer activity against liver cancxer cell line (HEPG2). Some of the screened compounds exhibited interesting cytotoxic activity compared to Doxorubicin as a reference drug. The most active compounds were selected and evaluated for their ability to enhance the cell killing effect of gamma radiation; compound 15 was superior to doxorubicin in radiattion combination therapy.

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A, G. - A., S. M, B. U, A. C, H.?hnle M, F. M, M. J, W. L, and W. G., "Flavonoid Production in Transgenic Hop (Humulus lupulus L", Plant Cell Reports, 2011. Abstract

Hop is an important source of secondary metabolites, like flavonoids. Some of these are pharmacologically active. Often, their concentration in wild type plants is rather low.

A, Y., F. R, M. S, E. - R. M. S, E. - H. A, and G. M. A, "The association of HLA class II DR B1 alleles with HCV infection in Egyptian children", Arab Journal of Gastroenterology, vol. 12, issue 1, pp. 25–28, 2011. CU-PDF
A, K., S. S, E. E, and E. - R. M, "Epidemiology of Primary Nephrotic Syndrome in Egyptian Children", Journal of Nephrology, vol. 25, issue 5, pp. 732-7, 2011. CU-PDF.pdf
A, A., and F. M.A., "Evaluation of Intralesional Propranolol for Periocular Capillary Hemangioma", Clinical Ophthalmology, 2011. Abstract

Purpose: To evaluate the use of intralesional propranolol injection in the management of periocular capillary hemangiomas.

A, A. - E., T. MI, and A. - E. AA, "Development and in Vitro/in Vivo Evaluation of Etodolac Controlled Porosity Osmotic Pump Tablets", AAPS PharmSciTech, vol. 12, issue 2, 2011. cu_pdf.pdf
a, L. R. A., R. H. M. b, and H. S. M. c, Oxytocin inhibits NADPH oxidase and P38 MAPK in cisplatin-induced, , vol. 65, 2011. cu_pdf.pdf
A., A. - E., H. M., and S. S., "In Vitro Characterization and Release Study of Ambroxol Hydrochloride Matrix Tablets Prepared by Direct Compression", Pharmaceutical Development and Technology, 2011.
A., A., and F. M.A., "Changes in Binocular Function in Anisometropic Nonstrabismic Children with Optical Correction and Occlusion Therapy", Journal of American Association for Pediatric Ophthalmology and Strabismus, vol. 15, issue 6, pp. 545–550, 2011. AbstractCU-PDF

Purpose: To identify factors that influence binocular function in anisometropic, nonstrabismic children before and after optical correction and amblyopia therapy

A., W. A., E. H. M., H. Y. E., A. M. S., O. A.H., and K. S. M., "Therapeutic and Protective Effects of Biphenyl Dimethyl Dicarboxylate (DDB) and Silymarin in Human Infected with HCV and in Carbon Tetrachloride Induced Hepatitis in Rats", Journal of American Science, 2011. Abstract

This investigation aimed to evaluate the therapeutic activity of pure and commercial products of Biphenyl Dimethyl Dicarboxylate (DDB) and Silymarin in humans suffering from HCV and therapeutic and protective effects of Carbon tetrachloride (CCL4) induced liver damage in rats. Humans were divided into two groups: Group I: Normal controls (N=20), and group II: Patients suffering from chronic HCV infection; which were subdivided into two subgroups: A, ten patients received Silymarin 140 mg twice daily for one month and B, twenty patients received DDB 10 pilules (15 mg) twice daily for one month. Samples from control and treated groups were collected and obtained serum was analyzed for Aspartate aminotransaminase (AST), Alanine aminotransaminase (ALT), Alkaline phosphatase (ALP or Alk.ph.), Gamma Glutamic transaminase (GGT) and Serum bilirubin (total and direct). In addition, the effect of DDB or Silymarin administration on the mentioned biochemical parameters was measured. Other experiment was conducted in which rats were divided into nine groups, each group comprising of six rats. All rats except the control group were subjected to administration of Silymarin or DDB in pure and commercial products, before and after treatment with CCL4. All serum samples of rats were subjected to liver function tests including: (AST), (ALT), (ALP.) and serum bilirubin as well as kidney functions tests including: blood urea and serum creatinine. Histopathological examination of liver tissues was also performed. The results revealed that DDB improved liver functions in patients suffering from HCV infection, while Silymarin showed insignificant alteration for the same parameters. The raw and commercial products of Silymarin or DDB were significantly improved liver, kidney functions and the histopathological changes after induction of CCL4 toxic hepatitis in rats. Administration of DDB (commercial) for one month to patients suffering from chronic viral hepatitis resulted in a rapid decrease in serum transaminases, especially ALT. Treatment of rats by pure and commercial DDB for 7 days showed improvement in acute hepatocellular necrosis or hepatitisassociated hepatocellular damage caused by carbon tetrachloride. Administration of commercial Silymarin for one month was largely ineffective in patients suffering from viral hepatitis. The results of 7 days treatment by pure and commercial products of Silymarin in rats showed protection of liver tissue. Silymarin has an antioxidant effect. In rats Silymarin increased the level of total protein which indicates hepatoprotective activity as results of accelerate of regeneration process and production of liver cells. Obtained histopathological study confirmed the results of biochemical studies. It is concluded that a superiority and efficacy of DDB over Silymarin in normalizing the liver enzymes and serum bilirubin (total and direct) levels were achieved after treatment of humans suffering from HCV.

A.Ahmed, W., F. A. A. Bedair, A. E. H. O.M, and N. E.A., "Induction of Apoptosis, Necrosis and Differentiation in hepG2 Cell Line (Comparison Between Natural and Synthetic Products)", Nature and Science, vol. 9, issue 7, pp. 62, 2011. CU-PDF.pdf
A.Nour, S., and N. A.Sabry, "Regional versus IV Analgesics in Labor", Minerva Medica, vol. 102, issue 5, pp. 353-61, 2011. AbstractCU-PDF.pdf

Aim: The aim of this study was to compare combined spinal epidural (CSE), epidural (E) and IV pethidine analgesia and their effects on the fetus, newborn and the labor course.

A.Sabry, N., and E. E. - D. Omar, "Corticosteroids and ICU Course of Community Acquired Pneumonia in Egyptian Settings", pharmacology and Pharmacy, vol. 2, issue 2, pp. 73-81, 2011. Abstractcu_pdf.pdf

Background$ Pneumonia is the most common cause of community-acquired infection requiring ICU admission'/+&U/ S/VHU/of patients with severe community acquired pneumonia; CAPD/admitted to the ICU develops respiratory failure and require mechanical ventilation ;MVD'/Objectives$ To assess the efficacy and safety of adjunctive low dose hydrocortisone infusion treatment in Egyptian ICU patients with CAP' Methods$ Hospitalized patientsK clinically and radiologically diagnosed with CAPK were randomized to receive hydrocortisone %)'W mg,h IV infusion for H/days or placeboK/along with antibiotics' The end-points of the study were improvement in PaO)$FIO) ;PaO)$FIO)/X/*&&/":/!%&& increase from study entryD and SOFA score by study day V and the development of delayed septic shock' Results$/V& patients were recruitedK/ (& of them received hydrocortisone and the remaining (& received placebo' By study day VK hydrocortisone treated patients showed a significant improvement in PaO)$FIO) and chest radiograph scoreK and a significant reduction in C-reactive protein ;CRPD levelsK Sepsis-related Organ Failure Assessment ;SOFAD/ scoreK and

AA, B., Z. AR, L. SA, M. WS, M. AA, S. SE, S. MM, O. A, and A. - Z. H., "The Role of Cyclins and Cyclin Dependent Kinases in Development and Progression of Hepatitis C Virus-Genotype 4-Associated Hepatitis and Hepatocellular Carcinoma", Experimental and Molecular Pathology, 2011. Abstract

{Altered cell cycle regulatory genes expression contributes to HCV-associated liver disease. We sought to assess the role of cyclins and cyclin dependent kinases (CDKs) in HCV-associated CH and HCC. Aberrant expression of cyclins A, E, D1, CDK2 and CDK4 was assessed by immunohistochemistry and differential PCR in HCV-associated CH and HCC with pericarcinomatous foci (PCF). S phase fraction (SPF) was determined by flow cytometry. Results were correlated with overall survival (OS) in HCC patients. In HCC, cyclins A, E, D1, CDK2 and CDK4 protein overexpression was detected in 52.8%, 52.8%, 69%, 47% and 58% compared to 36.1%, 33%, 56%, 27.8%, 55.6% for CH and 36.1%, 27%, 30.6%, 27%, 50% for PCF. Gene amplification was detected in 38.9%, 33% 66%, 33%, 44% of HCC compared to 27.8%, 25%, 44%, 27.8%, 36% in CH and 25%, 22.2%, 38.9%, 27%, 33% in PCF. A significant difference was reported between HCC, CH, NHT regarding cyclins A, E, D1, CDK2 (p=0.007

AA, A. E. - B., S. HF, and K. RM, "2-Hydroxypropyl-ß-Cyclodextrin Complex with Ketotifen Fumerate for Eye Drops Preparations", International Journal of Drug Delivery, vol. 3, issue 2, pp. 228-240, 2011. AbstractCU-PDF

Ketotifen fumerate ophthalmic solution is an antihistaminic drug. The aim of this study was to develop a novel aqueous ketotifen eye drop formulation containin ketotifen/2-Hydroxypropyl-?-cyclodextrin complex, which has the ability to enhance the solubility of the drug at the physiological pH (7.4), consequently decreasing the irritation to the eye.

AA, A. E. - B., S. HF, and K. RM, "2-Hydroxypropyl-ß-Cyclodextrin Complex with Ketotifen Fumerate for Eye Drops Preparations", International Journal of Drug Delivery , vol. 3, pp. 228-240, 2011. CU-PDF.pdf
AA, T., E. R. MS, H. MS, S. HM, and E. T. S, "Bone Mineral Status in Children With Cholestatic Liver Diseases", Aust. J. Basic & Appl. Sci., vol. 7, issue 10, pp. 306, 2011. AbstractCU-PDF

Cholestasis can be defined as the accumulation of substances normally excreted in bile (e.g. bilirubin, bile acids, and cholesterol). The process occurs as a result of impaired bile formation by the hepatocytes or from obstruction to the flow of bile through the intra hepatic and extra hepatic biliary tree. The aim of this study was to make laboratory assessment of bone mineral status and detection of the impact of different biliary diseases, its severity, duration and applied management on these values. The present study included forty patients, twenty four males (60%) and sixteen females (40%) who had cholestatic liver diseases for more than 3 months and followed up in the hepatology clinic, Cairo University and twenty healthy age and sex matched controls.

Abbas, S. S., N. E. Wagieh, M. Abdelkawy, and M. M. Abdelrahman, "Simultaneous Determination of Diloxanide Furoate and Metronidazole in Presence of Diloxanide Furoate Degradation Products", AOAC, vol. 94, issue 5, pp. 1427-39, 2011. AbstractCU-PDF.pdf

Three methods are presented for the simultaneous determination of Diloxanide furoate (DLX) and Metronidazole (MTR), used for their anti-protozoal and anti-amoebic effect, in presence of DLX alkaline degradates and in pharmaceutical formulations without previous separation.

Abbas, D. N., E. A. M. elGhafar, W. A. Ibrahim, and A. F.Omran, "Fluoroscopic Stellate Ganglion Block for Postmastectomy Pain: A Comparison of the Classic Anterior Approach and the Oblique Approach", Clin J Pain, vol. 27, issue 3, pp. 207-13, 2011. AbstractCU-PDF.pdf

Objective: Stellate ganglion block is usually performed with the classic anterior paratracheal approach. The anatomy of the stellate ganglion being in close proximity to various critical structures renders a number of complications, which are potentially associated with its blockade. The aim of this study was to assess the analgesic efficacy and safety of a new approach of the stellate ganglion block using an oblique fluoroscopic view.

Abd, Y. E. S., A. A. Tabll, N. G. B. E. Din, A. E. D. S. Hosny, R. I. Moustafa, R. El-Shenawy, K. Atef, and M. K. El-Awady, "Neutralizing Activities of Caprine Antibodies Towards Conserved Regions of the HCV Envelope Glycoprotein E2", Virology Journal, 2011. Abstract

Anti HCV vaccine is not currently available and the present antiviral therapies fail to cure approximately half of the treated HCV patients. This study was designed to assess the immunogenic properties of genetically conserved peptides derived from the C-terminal region of HVR-1 and test their neutralizing activities in a step towards developing therapeutic and/or prophylactic immunogens against HCV infection. Antibodies were generated by vaccination of goats with synthetic peptides derived from HCV E2. Viral neutralizing capacity of the generated anti E2 antibodies was tested using in vitro assays. Goats immunized with E2 synthetic peptides termed p412 [a.a 412-419], p430 [a.a 430-447] and p517 [a.a 517-531] generated high titers of antibody responses 2 to 4.5 fold higher than comparable titers of antibodies to the same epitopes in chronic HCV patients. In post infection experiments of native HCV into cultured Huh7.5 cells anti p412 and anti p 517 were proven to be neutralizing to HCV genotype 4a from patients' sera (87.5% and 75% respectively). On the contrary anti p430 exhibited weak viral neutralization capacity on the same samples (31.25%). Furthermore Ab mixes containing anti p430 exhibited reduced viral neutralization properties. From these experiments one could predict that neutralization by Abs towards different E2-epitopes varies considerably and success in the enrichment of neutralization epitope-specific antibodies may be accompanied by favorable results in combating HCV infection. Also, E2 conserved peptides p517 and p412 represent potential components of a candidate peptide vaccine against HCV infection.

Abd-Rabou, S., and N. A. Hani, "Length of Stay, Outcome and Nosocomial Infection among Neonates Admitted to the Neonatal Intensive Care Unit in El-Karak Governmental Hospital, Jordan", The New Egyptian Journal of Medicine, vol. 36, issue 1, 2007. Abstractcu_pdf.pdf

The current study utilized a descriptive prospective cohort research design, aiming to identify and describe the determinants length of stay and outcome, and to study the epidemiological pattern and determinants of nosocomial infection among neonates admitted to the neonatal intensive care unit (NICU) in El-Karak Governmental Hospital, Jordan. A total number of 135 neonates admitted to the NICU during the period from January to December 2004 were constituted the subjects of the present study. The required data were obtained through a pre-designed, pre-coded neonatal profile sheet constructed by the researchers after reviewing the relevant literature. The study results revealed that, the highest percentage of neonates stayed from two to seven days in the unit. The majority of the neonates were discharged alive from the unit. The mortality rate among neonates was 14%. Almost two fifths of the neonates suspected to have sepsis on admission, while less than fifth of them acquired sepsis during their hospital stay. There were highly statistically significant relationships between the length of stay of the neonates and their health problems and birth weight, highly statistically significant relationships were found between the hospital outcome of the neonates and their health problems, gestational age and birth weight. There were a statistically significant relationship between the occurrence of nosocomial infection and the birth weight of the neonates. The study recommended that, staff development programs should be developed based on need assessment in order to upgrade physicians’ and nurses’ knowledge and performance regarding the application of the infection control measures in the NICUs.

Abdallah, O. M., and A. M. Badaweyey, "Determination of Amlodipine and Valsartan in Binary Mixture Using Derivative", International Journal of Industrial Chemistry, vol. 69, issue 1, 2011. cu_pdf.pdf
Abdallah, H. M., M. M. Salama, E. H. Abd-elrahman, and S. A. EL-Maraghy, "Antidiabetic activity of phenolic compounds from Pecan bark in streptozotocin-induced diabetic rats", Phytochemistry Letters, vol. 4, issue 3, pp. 337–341, 2011. CU-PDF
Abdallah, D. M., and N. R. Ismael, "Resveratrol Abrogates Adhesion Molecules and Protects Against TNBS-Induced Ulcerative Colitis in Rats", Can. J. Physiol. Pharmacol, 2011. Abstract

Resveratrol, a polyphenol compound with anti-inflammatory properties, has been previously evaluated for its beneficial effects in several ulcerative colitis models. However, the current study elucidates the effect of resveratrol on adhesion molecules, as well as its antioxidant efficacy in a trinitrobenzene sulfonic acid (TNBS)-induced ulcerative-colitis model. Colitis was induced by rectal instillation of TNBS, followed by daily per os administration of either sulphasalazine (300 mg/kg) or resveratrol (2 and 10 mg/kg) for 7 days. Administration of resveratrol decreased the ulcerative area and colon mass index; these effects were further supported by the reduction in colon inflammation grades, as well as histolopathological changes, and reflected by the stalling of body mass loss. The anti-inflammatory effects of resveratrol were indicated by lowered myeloperoxidase activity, and by suppressing ICAM-1 and VCAM-1 levels in the colon and serum. In addition,it restored a reduced colonic nitric oxide level and reinstated its redox balance, as evidenced by the suppression of lipid peroxides and prevention of glutathione depletion. The anti-ulcerative effect of the higher dose of resveratrol was comparable with those of sulphasalazine. The study confirms the anti-ulcerative effect of resveratrol in TNBS-induced experimental colitis via reduction of neutrophil infiltration, inhibition of adhesive molecules, and restoration of the nitric oxide level, as well as the redox status.