Medical Sector

Citation:

Abdel-Aziz, H., N. Fawzy, A. I. Ismail, and H. El-Askary, "Toxicological Studies on A Standardized Extract of Solanum Indicum Ssp", Food and Chemical Toxicology, 2011.

Abstract:

A standardized extract of the fruits of Solanum distichum has previously been shown to possess antihypertensive activity in rats (ED50 about 1 mg/kg). Earlier acute toxicity studies had shown that single doses up to 2 g/kg orally or intraperitoneally failed to show any signs of morbidity. To study its potential long-term toxicity, rats of either sex were fed orally 1 g/kg of the extract daily over a period of 4 weeks to 6 months. The extract did not affect food intake or rate of growth of the animals. Blood counts and other hematological parameters remained unaffected. Treatment for 4 weeks had no effect on plasma cholesterol or blood urea nitrogen in both sexes, but extended treatment to 6 months tended to lower both parameters. Plasma creatinine, liver enzymes and fasting blood sugar, plasma electrolytes, total protein and albumin were not altered. Gross necropsy showed a 20% increase in liver to body weight ratios after 6 months.

Notes:

n/a