@article {738,
	title = {Synthesis and Anti-inflammatory Activity of Some Pyrazole Derivatives},
	journal = {Medicinal Chemistry Research},
	year = {2011},
	note = {<p>n/a</p>
},
	abstract = {<p>A novel series of pyrazoles containing N-substituted benzenesulfonamides, 1,3,4-oxadiazole-2-thiones, 4-substituted-1,2,4-triazole-3-thiones and 2-substituted-1,3,4-thiadiazoles has been synthesized. Anti-inflammatory activity screening of some synthesized compounds was evaluated in vivo utilizing a standard acute carrageenan-induced paw oedema method in rats and the most promising prepared anti-inflammatory active agents 3, 8f and 10f were evaluated for ulcerogenic liability in rats using indomethacin as a reference standard. Molecular modeling studies were initiated herein in order to validate the attained pharmacological data and provide understandable evidence for the observed anti-inflammatory behavior.</p>
},
	attachments = {https://scholar.cu.edu.eg/sites/default/files/medial_sector/files/art-3a10.1007-2fs00044-011-9691-4.pdf},
	author = {Samir M. El-Moghazy and Flora F. Barsoum and Hamdy M. Abdel-Rahman and Adel A. Marzouk}
}
