Spinal cord glioblastoma multiforme in a patient with Noonan syndrome: A clinical report.

Citation:
Khan, A., M. A. R. Soliman, M. M. Ghannam, P. K. Jowdy, R. Hess, M. J. Recker, and R. M. Reynolds, "Spinal cord glioblastoma multiforme in a patient with Noonan syndrome: A clinical report.", Clinical neurology and neurosurgery, vol. 207, pp. 106725, 2021.

Abstract:

INTRODUCTION: Currently, there are only 3 reported cases of central nervous system malignancies in patients with Noonan syndrome in the literature, all of which are intracranial pathologies. To our knowledge, there are no cases of spinal cord glioblastoma multiforme reported in the literature.

CASE DESCRIPTION: We describe the case of a 12-year-old girl with Noonan syndrome who presented with back pain and new onset neurological deficits and was found to have a spinal cord lesion. T10-L1 laminoplasty with safe maximal resection was done. Postoperative pathological analysis identified this lesion as a high-grade astrocytoma consistent with glioblastoma multiforme.

CONCLUSIONS: Spinal cord glioblastoma multiforme is a rare occurrence in the general population, particularly in a patient with an underlying diagnosis of Noonan syndrome. Patients with spinal cord tumors can present with a multitude of clinical signs and symptoms and treatment should not be delayed.