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Bosseila M, ElSayed K, El-Din SS, Monaem NA. Evaluation of Angiogenesis in Early Mycosis Fungoides Patients: Dermoscopic and Immunohistochemical Study. Dermatology. 2015;31(1):82-6. Abstractangiogenesis_proofs-dermatology_journal2015.pdfWebsite

BACKGROUND:
Angiogenesis is the production of new blood vessels from an existing vascular network; it plays a critical role in solid tumor development and metastasis.
OBJECTIVES:
To assess angiogenesis in early cases of mycosis fungoides (MF) and to determine vascular patterns in MF dermoscopically.
METHODS:
25 patients with MF and 20 healthy controls were included. The MF lesions were assessed dermoscopically. CD34 immunohistochemistry was performed to count dermal microvessel density (MVD).
RESULTS:
The total dermal MVD was significantly higher in MF patients (19.77 ± 5.81) than in controls (4.44 ± 3.16; p = 0.013). Among them, there were 10.8 ± 4.1 sprouts of endothelial buds (clusters of cells per field) in patients and 2.4 ± 2 in controls (p = 0.000). The dotted pattern of blood vessels was the most frequently encountered pattern in the MF lesions by dermoscopy.
CONCLUSIONS:
Our findings support that neoangiogenesis is significantly increased in early MF lesions and that the main dermoscopic feature of MF is dotted blood vessels.

Bosseila M, Tawfic SO, Ezzat MA, Shaker OG. Tissue liver X-receptor-$\alpha$ (LXR$\alpha$) level in acne vulgaris. Journal of the Egyptian Women’s Dermatologic Society. 2013;10:101-5. AbstractWebsite

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Bosseila M, Elkholy A, Hussein H. Infective endocarditis in children with atopic dermatitis. In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. Vol 64. MOSBY-ELSEVIER 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA; 2011. p. AB56. Abstract
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Bosseila M, Mahgoub D, El-Sayed A, Salama D, El-Moneim MA, Al-Helf F. Does fluorescence diagnosis have a role in follow up of response to therapy in mycosis fungoides? Photodiagnosis and photodynamic therapy. 2014;11:595-602. AbstractWebsite

Abstract
BACKGROUND:
Monitoring of tumor burden during mycosis fungoides (MF) treatment, is crucial to adjust therapy accordingly. This is usually achieved through combined by clinical assessment with histopathological and immunohistochemical evaluation.
AIM:
To assess the validity of fluorescence diagnosis (FD) in the measurement of response to therapy in early MF, using in comparison flow cytometric technique of skin biopsies for CD4+/CD7- malignant T-cell count before and after therapy.
PATIENTS AND METHODS:
Twenty-two patients of histologically proven early MF (stages Ia, Ib, IIa) were subjected to fluorescence diagnosis of their most affected skin lesion before and after 12 weeks of phototherapy with or without combination therapy. In comparison flow cytometric assessment of skin biopsies for CD4+/CD7- malignant T-cell count was evaluated before and after therapy from skin biopsy of the same lesion.
RESULTS:
All tested MF lesions showed varying degrees of fluorescence by FD at week zero, with a mean accumulation factor (AF), which is the fluorescence ratio between the tumor tissue and normal skin, of 2.2. After 12 weeks of therapy, the mean AF showed significant reduction to 1.94 (p=0.009). The percent of CD4+/CD7- cells dropped significantly after treatment (p=0.029). No correlation between CD4+/CD7- cell counts and the mean AF could be deduced.
CONCLUSION:
In cases of mycosis fungoides, fluorescence diagnosis can represent an effective tool for evaluating the response to therapy. Changes in accumulation factor values can be used for follow-up of therapy in the same patient, but it should not be used as an absolute value.

Bosseila M, Saad B. Quantitative morphometric analysis of hair follicles in alopecia areata. Journal of dermatological science. 2006;44:59-61. Abstract
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