Publications

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Bosseila M, Elkholy A, Hussein H. Infective endocarditis in children with atopic dermatitis. In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. Vol 64. MOSBY-ELSEVIER 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA; 2011. p. AB56. Abstract
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Bosseila M, Saad B. Quantitative morphometric analysis of hair follicles in alopecia areata. Journal of dermatological science. 2006;44:59-61. Abstract
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Bosseila M, Nabarawy EA, Latif MA, Doss S, ElKalioby M, Saleh MA. Scalp Pemphigus Vulgaris Mimicking Folliculitis Decalvans: A Case Report. Dermatology practical & conceptual. 2019;9(3):215-7.
Bosseila M, Tawfic SO, Ezzat MA, Shaker OG. Tissue liver X-receptor-$\alpha$ (LXR$\alpha$) level in acne vulgaris. Journal of the Egyptian Women’s Dermatologic Society. 2013;10:101-5. AbstractWebsite

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Bosseila M, ElSayed K, El-Din SS, Monaem NA. Evaluation of Angiogenesis in Early Mycosis Fungoides Patients: Dermoscopic and Immunohistochemical Study. Dermatology. 2015;31(1):82-6. Abstractangiogenesis_proofs-dermatology_journal2015.pdfWebsite

BACKGROUND:
Angiogenesis is the production of new blood vessels from an existing vascular network; it plays a critical role in solid tumor development and metastasis.
OBJECTIVES:
To assess angiogenesis in early cases of mycosis fungoides (MF) and to determine vascular patterns in MF dermoscopically.
METHODS:
25 patients with MF and 20 healthy controls were included. The MF lesions were assessed dermoscopically. CD34 immunohistochemistry was performed to count dermal microvessel density (MVD).
RESULTS:
The total dermal MVD was significantly higher in MF patients (19.77 ± 5.81) than in controls (4.44 ± 3.16; p = 0.013). Among them, there were 10.8 ± 4.1 sprouts of endothelial buds (clusters of cells per field) in patients and 2.4 ± 2 in controls (p = 0.000). The dotted pattern of blood vessels was the most frequently encountered pattern in the MF lesions by dermoscopy.
CONCLUSIONS:
Our findings support that neoangiogenesis is significantly increased in early MF lesions and that the main dermoscopic feature of MF is dotted blood vessels.

Bosseila M, Mahgoub D, El-Sayed A, Salama D, El-Moneim MA, Al-Helf F. Does fluorescence diagnosis have a role in follow up of response to therapy in mycosis fungoides? Photodiagnosis and photodynamic therapy. 2014;11:595-602. AbstractWebsite

Abstract
BACKGROUND:
Monitoring of tumor burden during mycosis fungoides (MF) treatment, is crucial to adjust therapy accordingly. This is usually achieved through combined by clinical assessment with histopathological and immunohistochemical evaluation.
AIM:
To assess the validity of fluorescence diagnosis (FD) in the measurement of response to therapy in early MF, using in comparison flow cytometric technique of skin biopsies for CD4+/CD7- malignant T-cell count before and after therapy.
PATIENTS AND METHODS:
Twenty-two patients of histologically proven early MF (stages Ia, Ib, IIa) were subjected to fluorescence diagnosis of their most affected skin lesion before and after 12 weeks of phototherapy with or without combination therapy. In comparison flow cytometric assessment of skin biopsies for CD4+/CD7- malignant T-cell count was evaluated before and after therapy from skin biopsy of the same lesion.
RESULTS:
All tested MF lesions showed varying degrees of fluorescence by FD at week zero, with a mean accumulation factor (AF), which is the fluorescence ratio between the tumor tissue and normal skin, of 2.2. After 12 weeks of therapy, the mean AF showed significant reduction to 1.94 (p=0.009). The percent of CD4+/CD7- cells dropped significantly after treatment (p=0.029). No correlation between CD4+/CD7- cell counts and the mean AF could be deduced.
CONCLUSION:
In cases of mycosis fungoides, fluorescence diagnosis can represent an effective tool for evaluating the response to therapy. Changes in accumulation factor values can be used for follow-up of therapy in the same patient, but it should not be used as an absolute value.

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El Batawi MM, Arnaot H, Shoeib S, Bosseila M, El Fangary M, Helmy AS. Prevalence of non-dermatophyte molds in patients with abnormal nails. Egypt Dermatol Online J. 2006;2:1-12. Abstract
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El-Batawy MM, Bosseila MA, Mashaly HM, Hafez VS. Topical calcineurin inhibitors in atopic dermatitis: a systematic review and meta-analysis. Journal of dermatological science. 2009;54:76-87. Abstract
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El-Darouti MA, Marzouk SA, Bosseila M, abu Zeid O, El-Safouri O, Zayed A, et al. Microscopic study of normal skin in cases of mycosis fungoides. International journal of dermatology. 2006;45:1043-6. Abstract
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El-Mofty M, Mostafa W, Esmat S, Youssef R, Bosseila M, HEGAZY RA. Phototherapy in vitiligo: a comparative evaluation of various therapeutic modalities. Journal of the Egyptian Women’s Dermatologic Society. 2012;9:123-35. Abstract
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El-Mofty M, Mostafa W, El-Darouty M, Bosseila M, Nada H, Yousef R, et al. Different low doses of broad-band UVA in the treatment of morphea and systemic sclerosis. Photodermatology, photoimmunology & photomedicine. 2004;20:148-56. Abstract
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El-Mofty M, Mostafa W, Esmat S, Youssef R, Bousseila M, Nagi N, et al. Suggested mechanisms of action of UVA phototherapy in morphea: a molecular study. Photodermatology, photoimmunology & photomedicine. 2004;20:93-100. Abstract
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El-Mofty M, El-Darouty M, Salonas M, Bosseila M, Sobeih S, Leheta T, et al. Narrow band UVB (311 nm), psoralen UVB (311 nm) and PUVA therapy in the treatment of early-stage mycosis fungoides: a right–left comparative study. Photodermatology, photoimmunology & photomedicine. 2005;21:281-6. Abstract
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El-Mofty M, Mostafa WZ, Bosseila M, Youssef R, Esmat S, Ramly EA, et al. A large scale analytical study on efficacy of different photo (chemo) therapeutic modalities in the treatment of psoriasis, vitiligo and mycosis fungoides. Dermatologic therapy. 2010;23:428-34. Abstract
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El-Mofty M, Zaher H, Bosseila M, Yousef R, Saad B. Low-dose broad-band UVA in morphea using a new method for evaluation. Photodermatology, photoimmunology & photomedicine. 2000;16:43-9. Abstract
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ElMofty M, Bosseila M, Mashaly HM, Gawdat H, Makaly H. Broadband ultraviolet A vs. psoralen ultraviolet A in the treatment of vitiligo: a randomized controlled trial. Clinical and experimental dermatology. 2013;38:830-5. AbstractWebsite

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ElMofty M, Mostafa W, Bosseila M, Youssef R, Essmat S, El Ramly A, et al. A large scale analytical study on efficacy of different photo (chemo) therapeutic modalities in the treatment of psoriasis. In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. Vol 24. WILEY-BLACKWELL PUBLISHING, INC COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA; 2010. p. 46. Abstract
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Errichetti E, Ankad BS, Jha AK, Sonthalia S, Akay BN, Bakos R, et al. International Dermoscopy Society criteria for non-neoplastic dermatoses (general dermatology): validation for skin of color through a Delphi expert consensus. International journal of dermatology. 2021. Abstract

BACKGROUND: The International Dermoscopy Society (IDS) recently released a set of five basic dermoscopic parameters (vessels, scales, follicular findings, "other structures," and specific clues) encompassing a total of 31 subitems to standardize the use of dermoscopy in non-neoplastic dermatoses, yet they have been developed taking into account Caucasian/Asian skin, with consequent possible limitations if used in dark skin.

OBJECTIVES: To validate the abovementioned criteria for the use in dark-skinned patients (phototypes IV-VI) through an expert consensus.

METHODS: The two-round Delphi method was adopted, with an iterative process consisting of two rounds of email questionnaires. Potential panelists were recruited via e-mail from all over the world based on their expertise on dermoscopy of non-neoplastic dermatoses in skin of color.

RESULTS: Twenty-two panelists took part in the validation process. All of the five originally proposed parameters and subitems reached agreement during the first round, aside from "follicular red dots." Additionally, during round 1, five new subitems were proposed (perifollicular scales distribution, follicular openings obliteration, broken hairs, eccrine pigmentation, and eccrine ostia obliteration), along with the possibility to change the denomination of parameter 3 (from "follicular findings" to "follicular/eccrine findings") and split it into two subparameters ("follicular findings" and "eccrine findings"). All such proposals reached agreement during the second round and therefore were included in the final list, for a total of 37 items.

CONCLUSIONS: Although nearly all the dermoscopic criteria originally proposed by the IDS are applicable even to darker phototypes, several additional variables need to be assessed.

Errichetti E, Ankad BS, Sonthalia S, Jha AK, Keshavamurthy V, Kyrgidis A, et al. Dermoscopy in general dermatology (non-neoplastic dermatoses) of skin of colour: a comparative retrospective study by the International Dermoscopy Society. European journal of dermatology : EJD. 2020;30(6):688-98. Abstract

BACKGROUND: Dermoscopy has been shown to be a useful supportive tool to assist the diagnosis of several non-neoplastic dermatoses (i.e. inflammatory, infiltrative and infectious skin diseases), yet data on skin of colour is still limited.

OBJECTIVES: To characterize dermoscopic features of non-neoplastic dermatoses in dark-skinned patients in order to identify possible clues that may facilitate the differential diagnosis of clinically similar conditions.

MATERIALS & METHODS: Members of the International Dermoscopy Society were invited to submit cases of any non-neoplastic dermatosis developing in patients with Fitzpatrick Phototypes V-VI whose diagnosis had been confirmed by the corresponding gold standard diagnostic test. A standardized assessment of the dermoscopic images and a comparative analysis according to clinical presentation were performed. Seven clinical categories were identified: (I) papulosquamous dermatoses; (II) facial hyperpigmented dermatoses; (III) extra-facial hyperpigmented dermatoses; (IV) hypopigmented dermatoses; (V) granulomatous dermatoses; (VI) sclerotic dermatoses; and (VII) facial inflammatory dermatoses.

RESULTS: A total of 653 patients (541 and 112 with Phototype V and VI, respectively) were recruited for the analysis. Thirty-six statistically significant dermoscopic features were identified for papulosquamous dermatoses, 24 for facial hyperpigmented disorders, 12 for extra-facial hyperpigmented disorders, 17 for hypopigmented disorders, eight for granulomatous dermatoses, four for sclerotic dermatoses and 17 for facial inflammatory diseases.

CONCLUSION: Our findings suggest that dermoscopy might be a useful tool in assisting the diagnosis of clinically similar non-neoplastic dermatoses in dark phototypes by revealing characteristic clues. Study limitations include the retrospective design, the lack of a direct dermoscopic-histological correlation analysis and the small sample size for less common diseases.