Medicinal and aromatic higher plants are sustainable resources for natural product compounds, including
essential oils, phenolics, flavonoids, alkaloids, glycosides, and saponins. Extractives and essential oils as well as
their bioactive compounds have many uses due to their antimicrobial, anticancer, and antioxidant properties as
well as application in food preservation. These natural compounds have been reported in many works, for
instance biofungicide with phenolic and flavonoid compounds being effective against mold that causes discoloration
of wood. Additionally, the natural extracts from higher plants can be used to mediate the synthesis of
nanoparticle materials. Therefore, in this review, we aim to promote and declare the use of natural products as
environmentally eco-friendly bio-agents against certain pathogenic microbes and make recommendations to
overcome the extensive uses of conventional pesticides and other preservatives.