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2023
Kotb, M. A., H. Abd El Baky, S. Sayed, M. A. Komy, M. Onsy, A. Aly, A. Tamer, and E. Mohamed, "Autosomal Recessive Polycystic Kidney Disease in a Child Complicated by Autoimmune Hemolytic Anemia: A Case Report", Pediatric Sciences Journal, vol. 3, issue 1, pp. 67-71, 2023.
Eid, M. S., M. A. Kotb, S. Salah, and S. E. Z. Houchi, "Thyrotoxicosis Masquerading as Superior Mesenteric Artery Syndrome in An Adolescent", Pediatric Sciences Journal, vol. 3, issue 1, pp. 64-66, 2023.
2022
FAROUK, M., S. Kaddah, and M. Kotb, "Anorectal Malformation: An Atypical Association of Pierre Robin Sequence", Pediatric Sciences Journal, vol. 2, issue 1, pp. 104-107, 2022. Anorectal Malformation: An Atypical Association of Pierre Robin Sequence
Mansour, L., M. Kotb, E. el Sobky, L. Tarek, W. Elnaggar, and M. Kamel, "Ataxia Telangiectasia: A Single Center Experience in a Decade", Pediatric Sciences Journal , vol. 2, issue 1, pp. 1-9, 2022. Ataxia Telangiectasia: A Single Center Experience in a Decade
Kotb, M. A., L. A. Fawaz, R. A. Zeitoun, Y. M. Shaalan, N. Aly, H. Abd El Kader, G. Eltagy, H. Esmat, A. F. Hamza, and H. Abd El Baky, "Bone demineralization in a cohort of Egyptian pediatric liver transplant recipients: Single center pilot study.", Medicine, vol. 101, issue 45, pp. e31156, 2022. Abstract

Liver transplantation (LT) is the definitive treatment of end-stage liver disease. The long-term survival following LT spurred more interest in improving the quality of life of patients. This was a cohort study that included 23 pediatric liver transplant recipients who underwent LT due to hereditary or metabolic liver diseases. Bone health assessment was performed at their last follow up clinically (anthropometric measures), biochemically and radiologically (Dual Energy X-ray Absorptiometry [DEXA] scans). Poor bone health was defined as z-score <-1. Mean age at LT was 5.77 years (standard deviation [SD] 3.64) and 43% were males. Biliary atresia was the most common cause of end stage liver disease (35%). Mean age at follow up was 14 years (SD 5.48) and mean follow up was 8 years (SD 4.12 years). Eleven patients (48%) had poor bone health (osteopenia 22% and osteoporosis 26%). On univariate analysis, being on steroids at last follow up (odds ratio [OR] 13.2, 95% confidence interval [CI] 1.23-140.67, P = .03), weight at last follow up (OR 0.45, 95% CI 0.20-0.99, P = .04), platelets at last follow up (OR 0.98, 95% CI 0.96-s0.99, P = .02), hemoglobin at last follow up (OR 0.33, 95% CI 0.12-0.89, P = .03) were significantly associated with poor bone health. None of the variables were significant on multivariate analysis. At most recent follow up, 48% of patients demonstrated poor bone health by DEXA scans. More studies are required to evaluate predictors of poor bone health after LT in children.

Kotb, M., M. ELGharib, H. Abdelkader, M. El-Monayeri, A. El-Hennawy, S. Kaddah, H. Abd El Baky, N. Abdalla, R. Shamma, and I. Abdelaziz, "Chronic Hepatic Venous Ischemia Secondary to Venous Outflow Insufficiency Causes Chronic Rejection in Pediatric Liver Transplant Recipients", Pediatric Sciences Journal, vol. 2, issue 1, pp. 89-98, 2022. cupsj_volume_2_issue_1_pages_89-98.pdf
Kotb, M. A., A. Kotb, S. Talaat, S. M. Shehata, N. El Dessouki, A. A. ElHaddad, G. Eltagy, H. Esmat, S. Shehata, M. Hashim, et al., "Congenital aflatoxicosis, mal-detoxification genomics & ontogeny trigger immune-mediated Kotb disease biliary atresia variant: SANRA compliant review.", Medicine, vol. 101, issue 39, pp. e30368, 2022. Abstract

Biliary atresia (BA) is the most common indication for pediatric liver transplantation. We describe The BA variant: Kotb disease. Liver tissue in the Kotb disease BA is massively damaged by congenital aflatoxicosis resulting in inflammation, adhesions, fibrosis, bile duct proliferation, scarring, cholestasis, focal syncytial giant cell transformation, and typical immune response involving infiltration by CD4+, CD8+, CD68+, CD14+, neutrophil infiltration, neutrophil elastase spill, heavy loads of aflatoxin B1, accelerated cirrhosis, disruption of p53 and GSTPi, and have null glutathione S transferase M1 (GSTM1). All their mothers are heterozygous for GSTM1. This inability to detoxify aflatoxicosis results in progressive inflammatory adhesions and obliterative cholangiopathy early in life. The typical disruption of both p53 and GSTPi causes loss of fidelity of hepatic regeneration. Hence, regeneration in Kotb disease BA typically promotes accelerated cirrhosis. The immune response in Kotb disease BA is for damage control and initiation of regeneration, yet, this friendly fire incurs massive structural collateral damage. The Kotb disease BA is about actual ongoing hepatic entrapment of aflatoxins with lack of ability of safe disposal due to child detoxification-genomics disarray. The Kotb disease BA is a product of the interaction of persistent congenital aflatoxicosis, genetic lack of GSTM1 detoxification, ontogenically impaired activity of other hepatic detoxification, massive neutrophil-elastase, immune-induced damage, and disturbed regeneration. Ante-natal and neonatal screening for aflatoxicosis, avoiding cord milking, and stringent control of aflatoxicosis content of human, poultry and live-stock feeds might prove effective for prevention, prompt diagnosis and management based on our recent understanding of its patho-genomics.

Kotb, M. A., F. Mostafa, M. Khalil, M. AbdelRaouf, L. Ammar, and N. Sabry, "Hepatitis Post Cardiopulmonary Bypass in Children: Single Center Experience in Egypt", Pediatric Sciences Journal, vol. 2, issue 1, pp. 82-88, 2022. cupsj_volume_2_issue_1_pages_82-88.pdf
Hala A. ElGindy, Mohamed F. Mohamed, Magd A. Kotb, Z. Ezzeldin, Hussein S. Hamdy, Mohamed F. Hussein, and W. M. Elnaggar, "Neonatal Auditory Screening is a Necessity in The Neonatal Intensive Care Unit: Single Center Study", Pediatric Sciences Journal , vol. 2, issue 2, pp. 120-126, 2022.
Magd A. Kotb, S. Kaddah, S. T. El Sorogy, Reham Osama, Naglaa El Kinaaiee, Sayed Khedr, and M. Gad, "Neonatal Biliary Obstruction Caused by Pancreatic Kaposi Hemangioendothelioma", Pediatric Sciences Journal , vol. 2, issue 2, pp. 210-215, 2022.
Hala A. ElGindy, Magd A. Kotb, Mohamed F. Mohamed, W. Abouelhamd, Nahed N. Alsabagh, N. Anis, and A. Elkazaz, "Non- Disjunction of Chromosome 21 in the Young Mother at Conception", Pediatric Sciences Journal , vol. 2, issue 2, pp. 164-169, 2022.
Kotb, M., N. Yassin, A. Lotfi, and S. Sayed, "Pattern of Renal and Urinary Tract Diseases Among Children Admitted to A General Ward Over One Year", Pediatric Sciences Journal, vol. 2, issue 1, pp. 46-53, 2022. cupsj_volume_2_issue_1_pages_46-53.pdf
Kotb, M., L. Hassan, A. Tamer, H. Abushady, E. Mohamed, and A. Aly, "Sarcoidosis in a Toddler: A Rare Presentation", Pediatric Sciences Journal, vol. 2, issue 1, pp. 108-111, 2022. cupsj_volume_2_issue_1_pages_108-111.pdf
Kotb, M., F. Mostafa, A. Badr, A. Hegazy, M. Eid, N. Sabry, and R. Shamma, "Structural and Functional Cardiac Changes in Children with Wilson Disease", Pediatric Sciences Journal, vol. 2, issue 1, pp. 72-81, 2022. cupsj_volume_2_issue_1_pages_72-81.pdf
Abdelaziz, I., M. Kotb, N. Yassin, W. A. Rabie, A. Alsayed, and D. Hamed, "Zinc Supplementation Improves Nocturnal Asthma Symptoms", Pediatric Sciences Journal, vol. 2, issue 1, pp. 10-16, 2022. cupsj_volume_2_issue_1_pages_10-16.pdf
2021
Kotb, M. A., D. Mosallam, H. A. Ragab;, A. E. H. Baky, E. A. Hatw, A. F. Hamza, A. E. H. Kader, E. G. Tagy, H. Esmat, S. Shehata, et al., " Management and Outcome of Chylous Ascites in Children: A CARE compliant Case Series", Pediatric Sciences Journal, vol. 1, issue 1, pp. 34-40, 2021.
Basanti, C., M. A. Kotb, N. Elsalawy, N. Telb, and A. K. Abdelmegeid, " Serum Folate in Asthma: Does it Correlate to Severity? A Single Center Experience", Pediatric Sciences Journal, vol. 1, issue 1, pp. 25-33, 2021.
Kotb, M. A., M. O. N. A. HAMDY, K. Eid, M. Aziz, M. Abd El Salam, H. Abd El Baky, N. Lotfi, and N. Salama, "Detoxification Genomics in Children with β- Thalassemia Major: Pilot Study of Glutathione S Transferase M1, Pi & Methyltetrahydrofolate Reductase Gene Polymorphisms Combinations in β- Thalassemia Major", Pediatric Sciences Journal, vol. 1, issue 2, pp. 99-106, 2021. _july_2021_thalassemia_proofs.pdf
Basanti, C. W., M. A. Kotb, A. M. Sayed, M. Ghanem, and A. K. Abdelmegeid, "Nasopharyngeal Microbiome Composition is Different Among Children with Bronchial Asthma", Pediatric Sciences Journal, vol. 1, issue 2, pp. 77-88, 2021. Nasopharyngeal Microbiome Composition is Different Among Children with Bronchial Asthma
Basanti, C., M. A. Kotb, H. M. Seif, F. I. Farag, and A. K. Abdelmegeid, "Pediatric Chest Ultrasound for Bedside Diagnosis of Pneumonia: A Validation Study for Diagnostic Options in Developing Countries", Pediatric Sciences Journal, vol. 1, issue 1, pp. 15-24, 2021.
Fadel, F. I., M. A. Kotb, M. A. Abdel Mawla, R. M. Hasanin, amr mohamed salem, M. G. Fathallah, K. S. Amr, H. A. Ahmed, and D. M. Salah, "Primary hyperoxaluria type 1 in children: Clinical classification, renal replacement therapy, and outcome in a single centre experience.", Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2021. Abstract

Primary hyperoxaluria type 1 (PH1) is a rare disease that is challenged by the overproduced oxalate and commonly presented with radiopaque renal stones or obstructive uropathy. This study aimed to report clinical presentations, renal replacement therapy (RRT), and outcome of PH1 in end stage kidney disease (ESKD) children. This is an observational cohort study. Data of 22 patients with ESKD due to PH1 were analyzed at Pediatric Nephrology Unit, Faculty of Medicine Cairo University. Infantile onset patients (n = 10) had worst renal outcome (80% with ESRD at presentation, p = 0.019) and worse patient outcome (mortality 40%, p = 0.016) than juvenile (n = 9) and late onset (PH1 n = 3) patients. RRT modalities include peritoneal dialysis (PD) in 7 (31.8%), hemodialysis (HD) in 11 (50%), and combined liver kidney transplantation (CLKT) in 4 (18.2%) patients. Infectious complications were encountered in 42.8% of PD patients. Better HD adequacy was observed with frequent HD (n = 6) and/or HD via arteriovenous fistula (AVF) than with infrequent dialysis (n = 5) and/or via central venous line (CVL) (p = 0.0001 and 0.0047, respectively). Morbidity and mortality (infection related) rates of the whole cohort were 63.6% and 31.8%, respectively. Clinical presentation of PH1 varies according to the age of onset (infantile onset being the most aggressive form). Aggressive HD (better through AVF) is needed to achieve acceptable HD adequacy, PD was challenged by infection. Infection found to be the main cause of mortality even after successful CLKT.

2020
Magd Ahmed Kotb, K. W. 2, Hesham Nabih Elmahdy, Hadeel Mohamed Seif El Dein, F. Z. Mostafa, Mohammed Ahmed Refaey, I. H. Draz, and C. W. S. Basanti, "The Machine Learned Stethoscope Provides Accurate Operator Independent Diagnosis of Chest Disease", Medical Devices: Evidence and Research, vol. 13, pp. 13—22, 2020. mder-221029-the-machine-learned-stethoscope-provides-accurate-operator-i.pdf