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Assem, M., R. E. El-Araby, A. A. Al-karmalawy, R. Nabil, M. A. M. Kamal, A. Belal, H. I. Ghamry, M. A. S. Abourehab, M. M. Ghoneim, M. Y. Alshahrani, et al., "PROMOTER METHYLATION MIGHT SHIFT THE BALANCE OF gALECTIN-3&12 EXPRESSION IN DE NOVO AML PATIENTS", FRONTIERS IN GENETICS, issue 10.3389, pp. 13, 2023. fgene-14-1122864_1.pdf
Elwy, F., Z. S. E. din, M. M. Assem, N. H. A. Hassan, and R. Helwa, "PTEN mutations prevalence in HER2-positive breast cancer patients", senologia-patologia-mamaria, vol. 410, issue 2022, pp. 7, 2022. 1-s2.0-s0214158222000482-main.pdf
Abdelfattah, M. M., M. M. Assem, A. A. El Leithy, R. Mahmoud, N. M. Allam, and R. Helwa, "Galectins in acute myeloid leukemia: Gene expression profiling with clinical emphasis", Age (years), vol. 5, issue 6, pp. 13.6, 2021. Abstract
Abdelhafeez, H. E. - D. A., F. A. F. Hamid, N. M. Hassan, M. M. Assem, and A. F. Soliman, "Relative expression and prognostic significance of forkhead box P3 in childhood B-cell acute lymphoblastic leukemia.", Pediatric blood & cancer, vol. 68, issue 10, pp. e29129, 2021. Abstract

BACKGROUND: Despite the favorable survival rates of childhood B-cell acute lymphoblastic leukemia (B-ALL), a significant number of patients present a dismal prognosis. Forkhead box P3 (FOXP3), a marker of regulatory T cells, functions as a transcription factor involved in immune cell regulation, and its expression correlates with prognosis in many malignancies. Therefore, this study aimed to assess the relative gene expression level of FOXP3 in childhood B-ALL and to detect its prognostic utility.

METHODS: The study included 139 bone marrow samples obtained from 112 patients at diagnosis and 27 healthy children. Following extraction, RNA was reverse transcribed and the relative expression level of FOXP3 was quantified by quantitative PCR. Cytogenetics, immunophenotype, and minimal residual disease were analyzed according to international guidelines.

RESULTS: A highly significant overexpression of FOXP3 was detected in childhood B-ALL patients at diagnosis, which was associated with a stronger risk for disease relapse and patients' worse survival. Moreover, multivariate regression models highlighted the independent prognostic value of FOXP3 for childhood B-ALL. Finally, the combination of FOXP3 relative expression with clinically used disease markers clearly enhanced the prediction of treatment stratification.

CONCLUSIONS: High FOXP3 relative expression was associated with inferior outcome suggesting its potentiality as a molecular prognostic marker to predict childhood B-ALL patients' outcomes.

El Leithy, A. A., R. Helwa, M. M. Assem, and N. H. A. Hassan, "Expression profiling of cancer-related galectins in acute myeloid leukemia", Tumor Biology, vol. 36: Springer Netherlands, pp. 7929–7939, 2015. Abstract
Assem, M. M., M. M. Noshy, G. M. Elsayed, H. N. 3 G. R. Thabet, G. M. Sherif, and A. K. Ahmad, "FLT3 internal tandem duplication and JAK2 V617F mutations in de novo acute myelogenous leukemia: relation with induction chemotherapy and overall survival", Life Sci J, vol. 9, pp. 1053–60, 2012. Abstract
Assem, M., A. T. Hamid, A. Kohla, and S. Arsanyos, "The prognostic significance of combined expression of ZAP-70 and CD38 in chronic lymphocytic leukemia", J Egypt Natl Canc Inst, vol. 21, no. 4, pp. 287–97, 2009. Abstract
Assem, M., A. Keshk, N. Ismail, and H. Nassar, "Specification-driven automated testing of java swing guis using xml", 2007 ITI 5th International Conference on Information and Communications Technology: IEEE, pp. 84–88, 2007. Abstract
Assem, M., S. E. H. A. M. Bahgat, M. A. G. D. A. El-Mahdey, S. Arsanyos, and others, "ZAP-70 and CD38 Expression in Egyptian CLL", Journal of the Egypt Society of Haemat and Res, vol. 3, no. 2, pp. 81–92, 2007. Abstract
Assem, M. M., W. A. L. A. A. H. Gad, N. M. El-Sharkawy, M. N. El-Rouby, F. M. Ghaleb, H. Tarek, and A. M. Kamel, "Prevalence of anti human herpes virus-6 IgG and its receptor in acute leukemia (membrane cofactor protein: MCP, CD46)", Journal of the Egyptian National Cancer Institute, vol. 17, no. 1, pp. 29–34, 2005. Abstract
Assem, M. M., M. A. G. D. A. M. El-Sayed, O. M. Mansour, T. A. R. E. K. M. El-Sergany, F. Salah, R. A. W. H. E. I. A. A. KHALIFA, and N. Hassan, "The Prognostic Value of International Prognostic Index and MIB-1 Immunostaining of Peripheral Lymphoid Tissues and Bone Marrow in Patients with High-Grade Non-Hodgkin's Lymphoma", Journal of the Egyptian Nat. Cancer Inst, vol. 13, no. 3, pp. 175–183, 2001. Abstract
Kamel, A. M., F. M. Ghaleb, M. M. Assem, D. S. Hindawy, E. S. Jaffe, and I. T. Magrath, "Phenotypic analysis of T-cell acute lymphoblastic leukemia in Egypt", Leukemia research, vol. 14, no. 7: Pergamon, pp. 601–609, 1990. Abstract
Kamel, A. M., M. M. Assem, E. S. Jaffe, I. Magrath, M. A. I. Enein, and D. S. Hindawy, "Immunological phenotypic pattern of acute lymphoblastic leukaemia in Egypt", Leukemia research, vol. 13, no. 7: Pergamon, pp. 519–525, 1989. Abstract