Randomized comparative efficacy and safety study of intermittent simvastatin versus fenofibrate in hemodialysis.

Citation:
Abdel Magid, A. M., M. M. Abbassi, E. E. M. Iskander, O. Mohamady, and S. F. Farid, "Randomized comparative efficacy and safety study of intermittent simvastatin versus fenofibrate in hemodialysis.", Journal of comparative effectiveness research, vol. 6, issue 5, pp. 413-424, 2017 Jul.

Abstract:

AIM: Compare the safety and efficacy of intermittent fenofibrate versus simvastatin in chronic hemodialysis patients.

PATIENTS & METHODS: Sixty patients received either fenofibrate 100 mg or simvastatin 20 mg after their dialysis session (parallel study). The safety and efficacy of drugs on lipid profile, oxidized low-density lipoprotein (Ox-LDL), glutathione peroxidase and C-reactive protein were compared before and after 16-week treatment.

RESULTS: After treatment, significant increase in glutathione peroxidase, significant decrease in total cholesterol, triglycerides, low density lipoprotein (LDL) and ox-LDL (p < 0.05) and no significant changes in C-reactive protein (p > 0.05) were observed in both groups. Both drugs were well tolerated with no serious side effects reported by the patients.

CONCLUSION: Both drugs have comparable efficacy and safety when used as intermittent low dose regimen in hemodialysis. Larger studies with longer follow-up periods are needed to confirm our new findings.