I., M. M., M. M. H, N. S. E., and G. A.,
Role of (Continuous glucose monitoring system) In optimizing glucose level in patients With type 1 diabetes mellitus,
, Cairo, Cairo univerity, 2010.
AbstractRole of Continuous glucose monitoring system in optimizing glucose level in patient
With type 1 diabetes mellitus. M.M. Kanishy, N. Salah Eldein, M.M. Hassan and G.M. Anwar
ABSTRACT
OBJECTIVES: The aim of this study is to assess the value of (CGMS) in detection of hypoglycemia, hyperglycemia and the possible role of (CGMS) in facilitating more optimum glucose control in children with type 1 diabetes mellitus.
PATIENTS AND METHODS: A total of 37 compliant children with type 1 diabetes for more than 1 year on intensive insulin therapy (age range 4 -22 years) were included in a non randomized non controlled interventional study for 6 month. The Continuous glucose monitoring system used was the MiniMed Meditronic CGMS gold system, the first model approved by FDA (Food and Drug Administration) and it was not real time CGMS. The CGMS reading were compared to that of SMBG (self monitoring of blood glucose) of at least 6 times a day during the period of study
RESULTS: The average number of hyperglycemic attacks detected by CGMS during the whole monitoring period was 11.7 ± 3, while the average number of hyperglycemic attacks detected by SMBG was 7 ± 2.4. CGMS based adjustment showed a reduction in the average number of hypoglycemic and hyperglycemic attacks with the P value (0.016) and (0.005) respectively. The average HbA1c was reduced significantly from 9.2 ± 1.2% before insulin dose adjustment to 7.8 ± 1.2 and 7.7 ± 1.3% at 3months and 6 months, respectively, after adjustment. The average cholesterol level at the onset was 177.3 ± 44 mg/dl. The cholesterol level was markedly reduced to average value of 161.1 ± 31 mg/dl after 6 months (P 0.000). The mean level of urinary microalbuminuria showed non-significant reduction in the level of urinary microalbuminuria 6 months after adjustment (P 0.112)
CONCLUSIONS: CGMS improved the rate of detection of hypoglycemic and hyperglycemic events. CGMS based adjustment showed marked improvement in glycemic control and in HBA1c values but not in the rates of microalbuminuria