Formulation and Availability of Loxoprofen Sodium Emulgel

Kassem, M. A. A., A. A. Swealem, and Z. R. Abd-El Aziz, "Formulation and Availability of Loxoprofen Sodium Emulgel", Egypt.J.Biomed.Sci., vol. 46, issue March, pp. 73-83, 2015.


Loxoprofen sodium is a non steroidal anti-inflammatory drug of the propionic acid group. It is used for the management of pain and inflammation associated with musculoskeletal and joint disorders or operative procedures.
The aim of this work was to formulate and optimize an emulgel formulation of loxoprofen sodium as drug delivery system to provide a prompt effect while avoiding its gastric irritant properties.
Nine different types of gelling agents were used vis., hydroxypropylmethyl cellulose (HPMC), Methyl 2-hydroxyethyl cellulose (Tylose® MH 300), methyl cellulose (MC), carboxymethylcellulose sodium (CMCS), hydroxyethyl cellulose (HEC), Carbopol 934, Carbopol 940, Pluronic F 127 and xanthan gum.
In addition, different excipients were used for performing multiple purposes.
The prepared emulgels were evaluated for their physical properties and rheological behavior. The influence of the type of the gelling agent on the drug release from the valid emulgels was also investigated.
Most of the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. Rheological studies revealed that the formulations exhibited a shear-thinning behavior with thixotropy. The drug release from the valid formulations was found to follow diffusion-controlled mechanism.