El Hadidi, K. T., B. M. Medhat, N. M. Abdel Baki, H. Abdel Kafy, W. Abdelrahaman, A. Y. Yousri, D. H. Attia, M. Eissa, D. El Dessouki, I. Elgazzar, et al.,
"Characteristics of systemic lupus erythematosus in a sample of the Egyptian population: a retrospective cohort of 1109 patients from a single center",
LupusLupus, vol. 27, issue 6: SAGE Publications Ltd STM, pp. 1030 - 1038, 2018.
AbstractIntroductionSystemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can vary among different ethnic and racial groups.ObjectiveThe objective of this paper is to study the prevalence of various manifestations of SLE in a sample of the Egyptian population.Patients and methodsInformation in this study was derived from the medical records of SLE patients who sought medical advice at a private clinic in Cairo from January 1980 to June 2016.ResultsThis study included 1109 SLE patients, of whom 114 (10.3%) were males and 995 were females (89.7%). Mean age of onset was 25.89?±?10.81 years, while the median of disease duration from the onset of the disease till the last recorded visit was 26 months. The most common cumulative manifestations were arthritis (76.7%), malar rash (48.5%), leukopenia (45.7%), and photosensitivity (45.6%). A total of 33.1% of the patients had nephritis, and neuropsychiatric lupus was present in 6.4% of the patients. Secondary antiphospholipid syndrome was present in 11.5% of the patients. Antinuclear antibody and anti-double-stranded deoxyribonucleic acid were present in 1060/1094 (96.9%) and 842/1062 (79.3%) of the patients, respectively. Antiphospholipid antibodies were present in 266/636 (41.8%) of the patients, anti-Smith in 54/240 (22.5%), anti-SSA/Ro in 61/229 (20.4%), and anti-SSB/La in 32/277 (11.6%) of the patients. Male patients had a statistically higher prevalence of nephritis (p?=?0.01), whereas arthritis and alopecia were statistically higher in females (p?=?0.012 and p?=?0.006, respectively). Patients with juvenile onset had a statistically higher prevalence of nephritis and seizures (p?<?0.001 and p?=?0.012, respectively).ConclusionsArthritis and malar rash represented the most common clinical manifestations. Male and juvenile-onset patients had a predilection toward a more severe disease. These results are in agreement with many studies conducted in the Middle East and worldwide. On the other hand, major organ involvement was exceptionally low, which is contradictory to several reports from the Middle East and across the globe.
El-serougy, E., H. S. Zayed, N. M. Ibrahim, and L. A. Maged,
"Procalcitonin and C-reactive protein as markers of infection in systemic lupus erythematosus: the controversy continues",
LupusLupus, vol. 28, issue 11: SAGE Publications Ltd STM, pp. 1329 - 1336, 2018.
AbstractObjectiveThe objective of this paper is to investigate the utility of serum procalcitonin (PCT) and C-reactive protein (CRP) as markers of infection in systemic lupus erythematosus (SLE) patients.Patients and methodsSixty-nine SLE patients with symptoms and signs of infection proved by culture and/or a favorable response to antibiotics and 69 SLE patients without infection were included. Serum PCT and plasma high-sensitivity CRP were assessed by an enzyme-linked immunosorbent assay.ResultsSLE patients with infection had a significantly higher level of CRP than those without infection ((median (IQR) 104.5 (25.5?100.9) and 10.3 (5.4?23.1) mg/l, respectively), p<0.001).ConclusionSerum PCT could not differentiate SLE patients with or without bacterial infection in this study, while the utility of CRP as a marker of infection has been confirmed.