Synthesis of the newly developed core-shell Au/Fe3O4 magnato-plasmonic nanocomposite in cancer cells

Ahmed, O. S. a, M. B. b Mohamed, A. - R. N. a Zekri, H. b Imam, H. M. a Khaled, and M. H. b c Abdel-Kader, "Synthesis of the newly developed core-shell Au/Fe3O4 magnato-plasmonic nanocomposite in cancer cells", Life Science Journal, vol. 11, no. 10: Zhengzhou University, pp. 182-187, 2014.


Background: Fe3O4-gold-Polyethyleneimine core-shell nanostructure can be used in biotechnological and biomedical applications.This research was conducted to assess the biocompatibility of the core-shell Fe3O4@Au nanocomposite, which have potential application in biomedical imaging. Results: Magnetite nanoparticles with an average size of 14 nm in diameter were synthesized using the chemical co-precipitation method. A gold-coated Fe3O4 monotonous core-shell nanostructure was produced with an average size of 21 nm in diameter by PEI reduction of Au3+. The results of analyses with electron diffraction, particle size, zeta potential,Transmission Electron Microscopy (TEM),) and vibrating sample magnetometer (VSM) indicated that the nanoparticles were regularly shaped, and agglomerate-free, with a narrow size distribution. We use the Laser Induced Breakdown Spectroscopy (LIBS) as a promising non-destructive technique for the spectral analysis of Gold - coated magnetic nanoparticles (Fe3O4). The biocompatibility of the obtained NPs, at concentration, was evaluated via MTT(3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay and the results showed that the NPs were non-toxic at concentrations 50μg /mL. Conclusions: A rapid, mild method for synthesizing Fe3O4-gold nanoparticles using Polyethyleneimine was investigated. A magnetic gold core-shell- Polyethyleneimine nanocomposite, including both the supermagnetic properties of iron oxide and the optical characteristics of colloidal gold nanoparticles, was synthesized.


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