Kamal, A., K. A. E. Einen, and I. Siam,
"Association of vascular endothelial growth factor - 634G/C and receptor for advanced glycation end products G82S gene polymorphisms with diabetic retinopathy",
Int J. Ophthalmol, vol. 9, issue 8, pp. 1106-1111, 2016.
Abstract·AIM: To investigate the association of receptor for
advanced glycation end products (RAGE) G82S and
vascular endothelial growth factor (VEGF) -634 G/C gene
polymorphisms with diabetic retinopathy (DR).
· METHODS: Our case -control study included 61
diabetic patients, 12 of them had proliferative diabetic
retinopathy (PDR), 15 had non proliferative diabetic
retinopathy (NPDR), 34 had no diabetic retinopathy (NDR)
and 61 healthy controls. Participants were tested for
RAGE G82S and VEGF -634 G/C polymorphisms by
polymerase chain reaction -restriction fragment length
polymorphism.
·RESULTS: We found a significant association between
VEGF -634 G/C polymorphism and PDR as PDR patients
had increased incidence of VEGF -634 CC genotype
compared to NDR patients [odds ratio for CC (GC+
GG)=6.5, 95% CI=1.5-27.8, =0.021]. Also VEGF -634 CC
genotype and C allele were significantly higher in the
PDR than in NPDR patients, which is a novel finding in
our study ( =0.024, 0.009 respectively). The mean
triglycerides level was significantly higher in diabetic
patients with CC genotype ( =0.01) as compared to
patients with other genotypes. All cases and control
subjects were of the same heterozygous RAGE 82G/S
genotype.