The effect of hexacontatetrapole deformation parameter on both the fusion cross-section and the barrier distribution have been studied for U238 + O16 nuclear pair using microscopically derived heavy ion (HI) potential. A method was described to extend the calculation of HI potential between two spherical nuclei using density dependent finite range NN forces to the spherical-deformed interacting pair. Density dependent and density independent effective NN forces were used in the generalized double folding model to derive the HI potential. We found that positive β6 has large effect on both the fusion cross-section and the barrier distribution in the presence of a small value of hexadecapole deformation parameter β4. In this case the fusion cross-section is less sensitive to the negative value of β6. In the presence of a large value of β4, negative and positive β6 values affect the fusion cross-section and have a small effect on the barrier distribution.

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