Cancer researchers discover pre-leukemic stem cell at root of AML, relapse

Tue, 2014-02-18 18:15

Cancer researchers have discovered a pre-leukemic stem cell that may be the first step in initiating disease and also the culprit that evades therapy and triggers relapse in patients with acute myeloid leukemia (AML).

Journal Reference

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  1. Liran I. Shlush, Sasan Zandi, Amanda Mitchell, Weihsu Claire Chen, Joseph M. Brandwein, Vikas Gupta, James A. Kennedy, Aaron D. Schimmer, Andre C. Schuh, Karen W. Yee, Jessica L. McLeod, Monica Doedens, Jessie J. F. Medeiros, Rene Marke, Hyeoung Joon Kim, Kwon Lee, John D. McPherson, Thomas J. Hudson, The HALT Pan-Leukemia Gene Panel Consortium, Andrew M. K. Brown, Quang M. Trinh, Lincoln D. Stein, Mark D. Minden, Jean C. Y. Wang, John E. Dick. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

    . Nature, 2014; DOI: 10.1038/nature13038

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