Export 13 results:
Sort by: Author Title Type [ Year  (Desc)]
ghaiad, H. R., M. A. Abd-Elmawla, E. S. Gad, K. A. Ahmed, and M. Abdelmonem, "Modulating miR-146a expression by hydrogen sulfide ameliorates motor dysfunction and axonal demyelination in cuprizone-induced multiple sclerosis", ACS Chemical Neuroscience, 2023.
El‐Gazzar, Y. I., H. R. ghaiad, A. E. M. Kerdawy, R. F. George, H. H. Georgey, K. M. Youssef, and H. I. El‐Subbagh, "New quinazolinone‐based derivatives as DHFR/EGFR‐TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity", Archiv der Pharmazie, vol. 356, issue 1, pp. 2200417, 2023.
Ghaiad, H. R., S. O. Ali, A. K. Al-Mokaddem, and M. Abdelmonem, "Regulation of PKC/TLR-4/NF-kB signaling by sulbutiamine improves diabetic nephropathy in rats ", Chemico-Biological Interactions, vol. 381, pp. 110544, 2023.
Abd-Elmawla, M. A., H. R. Ghaiad, E. S. Gad, K. A. Ahmed, and M. Abdelmonem, "Suppression of NLRP3 inflammasome by ivermectin ameliorates bleomycin-induced pulmonary fibrosis", Journal of Zhejiang University-SCIENCE B, , pp. 1-11, 2023.
Elkenawy, N. M., H. R. Ghaiad, S. M. Ibrahim, R. K. Aziz, E. Rashad, and W. A. Eraqi, "Ubiquinol preserves immune cells in gamma-irradiated rats: Role of autophagy and apoptosis in splenic tissue.", International immunopharmacology, vol. 123, pp. 110647, 2023. Abstract

Radiation has been applied in cancer treatment to eradicate tumors and displayed great therapeutic benefits for humans. However, it is associated with negative impacts on normal cells, not only cancer cells. Irradiation can trigger cell death through several mechanisms, such as apoptosis, necrosis, and autophagy. This study aimed to investigate the radioprotective efficacy of ubiquinol against radiation-induced splenic tissue injury in animals and the related involved mechanisms. Animals were classified into four groups: group 1 (normal untreated rats) received vehicle 5 % Tween 80; group 2 received 7 Gy γ-radiation; group 3 received 10 mg/Kg oral ubiquinol post-irradiation; and group 4 received 10 mg/Kg oral ubiquinol before and after (pre/post-) irradiation. Ubiquinol restored the spleen histoarchitecture, associated with improved immunohistochemical quantification of B and T lymphocyte markers and ameliorated hematological alterations induced by irradiation. Such effects may be due to an enhanced antioxidant pathway through stimulation of p62, Nrf2, and GSH, associated with reduced Keap1 and MDA. Moreover, ubiquinol decreased mTOR, thus enhanced autophagy markers viz. LC3-II. Furthermore, ubiquinol showed an antiapoptotic effect by enhancing Bcl-2 and reducing caspase-3 and Bax. Consequently, ubiquinol exerts a splenic-protective effect against irradiation via enhancing antioxidant, autophagic, and survival pathways.

Mehana, N. A., H. R. ghaiad, M. Hassan, Y. A. Elsabagh, S. Labib, and M. A. Abd-Elmawla, "LncRNA MEG3 regulates the interplay between Th17 and Treg cells in Behçet's disease and systemic lupus erythematosus", Life Sciences, vol. 309, pp. 120965, 2022.
ghaiad, H. R., A. N. Elmazny, M. M. Nooh, M. M. El-Sawalhi, and A. A. Shaheen, "Long noncoding RNAs APOA1-AS, IFNG-AS1, RMRP and their related biomolecules in Egyptian patients with relapsing-remitting multiple sclerosis: Relation to disease activity and patient disability", Journal of Advanced Research, vol. 21, pp. 141-150, 2019.
ghaiad, H. R., M. M. Nooh, M. M. El-Sawalhi, and A. A. Shaheen, "Resveratrol Promotes Remyelination in Cuprizone Model of Multiple Sclerosis: Biochemical and Histological Study", Molecular Neurobiology, 2016.
ghaiad, H. R., M. M. Nooh, M. M. El-Sawalhi, and A. A. Shaheen, Role of Resveratrol in ameliorating the biochemical changes in an experimental model of demyelinating disease in mice, , Cairo, Cairo University, 2016.