@article {21051,
	title = {Simultaneous determination of pramocaine HCl and hydrocortisone acetate in pharmaceutical dosage form},
	journal = {Journal of Liquid Chromatography \& Related Technologies},
	volume = {36},
	year = {2013},
	pages = {2774-2784},
	abstract = {<p>Two sensitive and selective methods were developed and validated for simultaneous determination of pramocaine HCl and hydrocortisone acetate in pharmaceutical dosage form. The first method is a spectro-densitometric method where pramocaine HCl and hydrocortisone acetate were separated using toluene: methanol: chloroform: 10\% NH3 (5:3:6:0.1, by volume) as developing system followed by densitometric measurement at 290 nm. The second method is a high performance liquid chromatographic method for separation and determination of both drugs using reversed phase C18 column and mobile phase consisting of distilled water: acetonitrile: triethylamine (530: 470: 0.1, by volume), pH was adjusted to 3 by o-phosphoric acid. The proposed methods were successfully applied for the analysis of pramocaine HCl and hydrocortisone acetate in laboratory prepared mixtures and in pharmaceutical dosage form and the results obtained were assessed by applying the standard addition technique. Statistical comparison between the results obtained by applying the proposed methods and official method for the cited drugs was done and no significant difference was found at p = 0.05</p>
},
	author = {Hanan A. Merey and Mohammed A. Mohammed and Fahima A. Morsy and Maissa Y. Salem}
}
