@article {116293, title = {Spectrophotometric and Chemometric Study for the Simultaneous Determination of Mometasone Furoate and Miconazole Nitrate in the presence of Pharmaceutical Dosage Form Additive}, journal = {Analytical Chemistry Letters}, volume = {6}, year = {2016}, pages = {70-85}, abstract = {

Mometasone Furoate (MO) and Miconazole Nitrate (MI) are co-formulated with p-chlorometa-cresol
(CMC) which added in pharmaceutical dosage form as a preservative together for treatment of skin
infections by candida or dermatophyte in which inflammatory and pruritic manifestation are prominent.
Comparative study between different specrtophotometric methods were done for the simultaneous determination
of cited drugs in the dosage form. Spectrophotometric methods were used including, derivative ratio spectra
(DD), derivative of double divisor of ratio spectra (DD-RS) and Mean centering of the ratio spectra (MCR).
While the chemometric methods were used including, partial least-squares (PLS) and principal component
regression (PCR). The linearity of the proposed methods was investigated in the range of 3-33 and 60-840 μg/
mL for MO and MI, respectively. The specificity of the developed methods was investigated by analyzing
laboratory prepared mixtures containing different ratios of cited drugs in addition to CMC and their pharmaceutical
dosage form. The validity of the proposed methods was assessed using the standard addition technique. The
obtained results were statistically compared with those obtained by the reported method, showing no significant
difference with respect to accuracy and precision at p = 0.05.

}, author = {Hanan A. Merey and Sally S. El-Mosallamy and Nagiba Y. Hassan and Badr A. El-Zeany} }