Publications

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2022
Ibrahim, N. M., S. H. Fahim, M. Hassan, A. E. Farag, and H. H. Georgey, "Design and synthesis of ciprofloxacin-sulfonamide hybrids to manipulate ciprofloxacin pharmacological qualities: Potency and side effects", European Journal of Medicinal Chemistry, vol. 228, pp. 114021, 2022. ejmc_2022.pdf
El-Aleam, R. A. H., A. M. Sayed, M. N. Taha, R. F. George, H. H. Georgey, and H. M. Abdel-Rahman, "Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation.", European Journal of Medicinal Chemistry, vol. 241, pp. 114629, 2022. EJMC_2022.pdf
Younis, M. H., E. R. Mohammed, A. R. Mohamed, M. M. Abdel-Aziz, H. H. Georgey, and N. A. M. Gawad, "Design, synthesis and anti-Mycobacterium tuberculosis evaluation of new thiazolidin-4-one and thiazolo[3,2-a][1,3,5]triazine derivatives.", Bioorganic Chemistry, vol. 124, pp. 105807, 2022. Bioorg. Chem._2022.pdf
2021
Ewida, M. A., H. A. Ewida, M. S. Ahmed, H. A. Allam, R. I. Elbagary, R. F. George, H. H. Georgey, and H. I. El-Subbagh, "3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations. ", Bioorganic Chemistry, vol. 115, pp. 105205, 2021.
El-Aleam, R. A. H., R. F. George, H. H. Georgey, and H. M. Abdel-Rahman, "Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance", RSC Adv., vol. 11, pp. 36459, 2021. RSC Adv._2021.pdf
Halim, P. A., H. H. Georgey, M. Y. George, A. E. M. Kerdawy, and M. F. Said, "Design and synthesis of novel 4-fluorobenzamide-based derivatives as promising anti-inflammatory and analgesic agents with an enhanced gastric tolerability and COX-inhibitory activity.", Bioorganic Chemistry, vol. 115, pp. 105253, 2021.
Mohamed, A. R., A. E. M. Kerdawy, R. F. George, H. H. Georgey, and N. A. M. Gawad, "Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7I)-dione derivatives with potent anticancer and multi kinase inhibitory activities.", Bioorganic Chemistry, vol. 107, pp. 104569, 2021.
Hassan, G. S., H. H. Georgey, E. Z. Mohammed, R. F. George, W. R. Mahmoud, and F. A. Omar, "Mechanistic selectivity investigation and 2D-QSAR study of some new antiproliferative pyrazoles and pyrazolopyridines as potential CDK2 Inhibitors. ", European Journal of Medicinal Chemistry, vol. 218, pp. 113389, 2021. ejmc-2021.pdf
Ewida, M. A., H. A. Ewida, M. S. Ahmed, H. A. Allam, R. I. Elbagary, R. F. George, H. H. Georgey, and H. I. El-Subbagh, "Nanomolar potency of imidazo[2,1‐b]thiazole analogs as indoleamine 2,3‐dioxygenase inhibitors.", Arch. Der. Pharm., vol. 354, pp. 2100202, 2021.
Said, M. F., H. H. Georgey, and E. R. Mohammed, "Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential", European Journal of Medicinal Chemistry, vol. 224, pp. 113682, 2021. EJMC_2021.pdf
Mohammed, E. Z., W. R. Mahmoud, R. F. George, G. S. Hassan, F. A. Omar, and H. H. Georgey, "Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs).", Bioorganic Chemistry, vol. 116, pp. 105347, 2021. Bioorganic_2021.pdf
2019
Georgey, H. H., F. M.Manhi, W. R. Mahmoud, N. A. Mohamed, E. Berrinoc, and C. T. Supuranc, "1,2,4-Trisubstitutedimidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity", Bioorganic Chemistry, vol. 82, pp. 109-116, 2019.
Hassan, G. S., H. H. Georgey, E. Z. Mohammed, and F. A. Omar, "Anti-hepatitis-C virus activity and QSAR study of certain thiazolidinone and thiazolotriazine derivatives as potential NS5B polymerase inhibitors", European Journal of Medicinal Chemistry, vol. 184, pp. 111747, 2019. 20-ejmc_esraa.pdf
2018
Hassan, G. S., H. H. Georgey, R. F. George, and E. R. Mohammed, "Construction of some cytotoxic agents with aurone and furoaurone scaffolds.", Future Med. Chem., vol. 10, issue 1, pp. 27–52 , 2018.
Rashad, M. S., H. H. Georgey, R. F. George, and N. M. Abdel-Gawad, "Identification of some benzoxazepines as anticancer agents inducing cancer cell apoptosis", Future Medicinal Chemistry, vol. 10, issue 14, pp. 1649-1664, 2018. 18-fmc-mohaned_shawky_2018.pdf
2017
Mohamed, A. R., H. H. Georgey, R. F. George, W. I. El-Eraky, D. O. Saleh, and N. A. M. Gawad, " Identification of some novel xanthine-based derivatives with bronchodilator activity. ", Future Med. Chem., vol. 9, issue 15, pp. 1731–1747, 2017.
El-Gazzar, Y. I., H. H. Georgey, S. M. El-Messery, H. A. Ewida, G. S. Hassan, M. M. Raafat, M. A. Ewida, and H. I. El-Subbagh, "3- Synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3H)-one as DHFR inhibitors.", Bioorganic Chemistry, vol. 72, pp. 282-292 , 2017.
Hassanein, H. H., G. Hanan H, M. A. Fouad, A. E. M. Kerdawy, and M. F. Said, "Synthesis and molecular docking of new imidazoquinazolinones as analgesic agents and selective COX-2 inhibitors. ", Future Med. Chem., vol. 9, issue 6, pp. 553-578, 2017.
2015
Hassan, G. S., H. H. Georgey, N. A. Ibrahim, and S. S. Zakib, "6- Synthesis of novel substituted quinazoline and quinazolin-4(3H)-one derivatives of expected antitumor activity", Der Pharm. Chem. , vol. 7, issue 7, pp. 106-119, 2015. der_pharma_chemica.pdf
Awadallah, F. M., S. M. Abou-Seri, M. M. Abdulla, and H. H. Georgey, "Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38aMAPK and ERK1/2 inhibitory activity. ", Eur. J. Med. Chem., vol. 94, pp. 397-404, 2015.
2014
Georgey, H. H., "Synthesis, Cytotoxic Activity and 2D-QSAR Study of Some Imidazoquinazoline Derivatives", molecules, vol. 19, pp. 3777-3792, 2014. molecules_2014-published_paper_hanan.pdf
2013
Ragab, F. A., N. A. M. Gawad, H. H. Georgey, and M. F. Said, "Pyrazolone Derivatives: Synthesis, Anti-inflammatory, Analgesic, Quantitative Structure–Activity Relationship and in Vitro Studies", Chem Pharm Bull, vol. 61, issue 8 , pp. 834–845, 2013. chem_pharm_bull.pdf
Ragab, F. A., N. A. M. Gawad, H. H. Georgey, and M. F. Said, "Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents", European Journal of Medicinal Chemistry , vol. 63 , pp. 645-654, 2013. Eur J Med Chem 2013
2012
Taher, A. T., H. H. Georgey, and H. I. El-Subbagh, "Novel 1,3,4-heterodiazole analogues: Synthesis and in-vitro antitumor activity.", European Journal of Medicinal Chemistry, vol. 46, issue 47, pp. 445-451, 2012. Abstract

The synthesis of some new heterodiazole and their annulated imidazo[2,1-b]1,3,4-oxa/thiadiazolone 6a–d, 7a–d; 1,3,4-oxa or thiadiazole[3,2-a]pyrimidine diamine 8a–d and 1,3,4-oxa or thiadiazole-3-piperidino-1-propamide 11a,b derivatives have been described. The obtained compounds were evaluated for their in-vitro antitumor activity. A single dose (10 μM) of the test compounds were used in the full National Cancer Institute (NCI) 60 cell lines panel assay. Compounds 6c and 6d displayed appreciable anticancer activity against leukemia, non-small cell lung, CNS and showed moderate activity against colon, melanoma, and breast cancer cells lines. Compound 6c possessed remarkable broad-spectrum antitumor activity which almost 4 fold more active than the known drug 5-FU with GI50, TGI, and LC50 values of 6.0, 17.4, and 55.1 μM, respectively.

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