Bio

Name:

        Hala Gabr Metwally

E-mail:      

halagabr@yahoo.com

                   halagabr@kasralainy.edu.eg

 

Education:

 

-  1995:       Doctor's Degree in Clinical and Chemical Pathology, Faculty of Medicine,CairoUniversity.  Title of the Thesis "Study of the Circulating Erythroid Progenitors in B-Thalassemia Major"

 

-  1992:       Master's Degree in  Clinical and Chemical Pathology, Faculty of Medicine,CairoUniversity.  Title of the Thesis:  "Amniotic fluid analysis in normal and abnormal pregnancies".

 

-  1987:       Bachelor's degree in Medicine & Surgery , Faculty of Medicine,CairoUniversity.

 

 

Work Experience:

 

-2006 to present: 

Professor of Hematology, Clinical Pathology Department, Faculty of Medicine,CairoUniversity.

 

-

2001-2006

:                             Assistant professor of Hematology, Clinical Pathology Department, Faculty of Medicine,CairoUniversity.

 

-

1995 to 2001:              

Lecturer of Hematology, Clinical Pathology Department, Faculty of Medicine,CairoUniversity.

 

-1992-1995:                  

Assistant lecturer of Hematology, Clinical Pathology Department, Faculty of Medicine,CairoUniversity.

 

-1989-1992:                  

Resident of clinical & chemical pathology, Faculty of Medicine,CairoUniversity.

 

-

1988-1989:                  

House officer,CairoUniversity hospitals.

 

 

 

Affiliations:

 

-        Member of the International Society for Hematology and Stem Cells "ISEH"

 

-   Member of the European Society for Gene and Cell Therapy (ESGCT)

 

-  Council member of the International Federation of  Neuro-restoratology.

 

-        Scientific advisor of the "Egyptian Foundation of Molecular Biology".

 

-  Scientific advisor of the "Egyptian Society for Progenitor Cell Research".

 

-  Member of the Egyptian society of Laboratory medicine

 

-  Member of the Egyptian society of Hematology & research

 

-  Reviewer for the European Journal of Gastroentrology and Hepatology.

 

 

Sub-speciality:

 

Tissue culture, cytogenetics and stem cell biology

 

 

 

Research Activities:

 

  1. A.     Master's Thesis Supervision:

 

  1. Chromosome 10 aneuploidy in childhood ALL
  2. Non-viral gene therapy in B-thalassemia major.
  3. Reversal of aberrant mRNA splicing in erythroid progenitors in B-thalassemia patients.
  4. P-selectin expression & GPIIbIIIa polymorphism in congenital heart defects.
  5. Evaluation of inhibitory effect of ASON in HCV-positive hepatocellular carcinoma
  6. Transdifferentiation of bone marrow & cord blood stem cells into B-islet cells.
  7. Antisense oligonucleotide – induced inhibition of CML progenitor proliferation.
  8. Isolation of fetal progenitors from maternal blood
  9. Evaluation of endothelial damage in Behcet's disease
  10. Mesenchymal stem cell injection in experimental canine osteoarthritis model.
  11. Autologous stem cell injection in rabbit encephalomyelitis model.
  12. Comparison between differentiated and undifferentiated mesenchymal stem cell injection for islet cell regeneration in diabetic canine model.
  13.    Comparison between mesenchymal subpopulations in bone marrow and leukaphersis samples.

 

 

 

  1. Doctor's Thesis Supervision:

 

  1. Cord blood megakaryocyte expansion:  effect of different cytokine combinations.
  2. Cord blood myeloid expansion
  3. Cord blood stem cell expansion:  effect of storage conditions on viability & expansion potential.
  4. Effect of CO2 on the expansion of long-term culture initiating cells in cord blood.
  5. Comparison between CD34 selection, CD133 selection and mononuclear cells on hepatocyte expansion.
  6. Evaluation of Autologous bone marrow stem cell injection in endstage liver cell failure.
  7. Evaluation of Stem Cell Injection in Myocardial Ischemia
  8. Hypoxic Ischemic neonates:  characterization of cord blood-derived mesenchymal stem cell therapy in reversal of cerebral degeneration.
  9. Neurological, Neurophysiological, and cognitive effects of autologous intrathecal injection of stem cells in cerebral palsy.
  10. Evaluation of the revascularization potential of mesenchymal stem cells in peripheral vascular ischemia.
  11. Melanocyte culture and intradermal implantation in cases of vitiligo.
  12. Autologous stem cell injection for neural regeneration in traumatic spinal cord injury.
  13. Morphological and Functional characteristics of myeloid progenitors in long term culture in CML
  14. Chromosomal sensitivity to oxidants and antioxidants in Fanconi & non-Fanconi aplastic anemia.
  15. Functional defects in megakaryocyte progenitors in cases of ITP.
  16. Apoptosis in circulating T-lymphocytes in HCV-positive patients.
  17. Generation of dendritic cells from AML blasts using IL-4 and G-CSF.
  18.  Transdifferentiation of mesenchymal stem cells into dopaminergic neurons.
  19. Fibroblast-mediated therapy for resistant venous leg ulcers.
  20. Comparison between different bone marrow stem cell subsets in correction of hyperglycemia in diabetic mice model.
  21. Stem cell therapy in cerebral palsy
  22.  Effect of autologous bone marrow mononuclear cells in revascularization in ischemic limb patients.
  23.  Autologous bone marrow derived stem cells in myocardial ishemia.
  24.   Mesenchymal stem cells and amniotic membrane grafting in treatment of chronic leg ulcers.
  25.   Comparison between bone marrow derived and adipose derived mesenchymal stem cells in transdifferentiation into insulin producing islet cells.

 

 

 

  1. Teaching Experience:

 

  1. Development of Regenerative Medicine Master's curriculum and program.
  2. Coordinator of  undergraduate curriculum and  teaching in the clinical pathology department since 2005.
  3. Participation in practical postgraduate teaching in Master's program of Clinical pathology department since 1998.
  4. Participation in teaching Hematology curriculum in Clinical Pathology department since 2001.
  5. Participation in undergraduate curriculum development in Clinical Pathology department.
  6. Participation in the House Officer Training Program since 2009.
  7. Establishment of a number of orientation programs for undergraduates for laboratory medicine and regenerative medicine.

 

 

 

  1. Research Projects:

 

  1. Principle investigator in the STDF-supported project:  "  Stem Cell Therapy in Liver Failure".

 

  1. Co-investigator in Cairo University-supported project:  "Limbal Stem Cell Characterization and Expansion".

 

 

  1. Co-investigator in Cairo University supported project:  "Identification of   Cancer Stem Cells in  Bladder Cancer"

 

  1. Laboratory consultant of the multicenter clinical trial in stem cell therapy in liver cell failure.

 

  1. Member of theAl-AzharUniversity, Neurosurgery Department Stem Cell Therapy for Spinal cord injuries project.

 

 

 

International Conferences & Publications:

 

1.  Autologous bone marrow-derived cell therapy combined with physical therapy induces functional improvement in chronic spinal cord injury patients.

El-Kheir WA, Gabr H, Awad MR, Ghannam O, Barakat Y, Farghali HA, Maadawi ZM, Ewes I, Sabaawy HE.

Cell Transplant. 2013

Feb 26.

 

2. COMPARISON BETWEEN DIFFERENT CORD BLOOD STEM CELL

POPULATIONS IN EFFICIENCY OF TRANSDIFFERENTIATION

INTO HEPATIC LINEAGE. Hala Gabr1, Rania Zayed1, Ahmed Rezk Elzayat21st Annual International Interdisciplinary Conference, AIIC 2013, 24-26 April, Azores, Portugal - Proceedings-762

 

 

1. Aly A, Mohsen l, badrawi N, Gabr H,  Ali Z, Akmal D:  Viability and neural differentiation of mesenchymal stem cells derived from umbilical cord following perinatal hypoxia.  J. Perinatol.: 1-6, 2011

 

2.   Limb salvage using intramuscular injection of unfractionated autologous bone marrow mononuclear cells in critical limb ischemia:  a prospective pilot clinical trial.  Gabr H, Hedayet A, Imam U, Nasser M.  Exp. Clin Transplant Jun; 9(3):197-202, 2011.

.

  1. Clinical and laboratory evaluation of patients with endstage liver cell failure injected with bone marrow-derived hepatocyte-like cells.  Amer ME, El-Sayed SZ, El-Kheir WA, Gabr H, Gomaa AA, El-Noomani N, Hegazy M.  Eur J Gastroenterol Hepatol Oct; 23(10):936-41, 2011.

 

Autologous Mesenchymal Stem Cells for Neuro-Regeneration After Traumatic Spinal Cord Injury:  A Comparison Between Bone Marrow and

Peripheral Blood Populations

Abo El-Kheir W, Gabr H,  Awad MR, von Wild K, and  Ramadan M

American Journal of Neuroprotection and Neuroregeneration Vol. 2, 1–8, 2010.

 

2.

Case Control Series of Intrathecal Autologous Bone Marrow Mesenchymal Stem Cell Therapy for Chronic Spinal Cord Injury.

 Nirmeen A. Kishk MD1, Hala Gabr MD2, Sherif Hamdy MD1,

LamiaAfifi MD3, Noha Abokresha MD1, Hayam Mahmoud MD4,

Ahmed Wafaie MD5, and Dalia Bilal MD6

 Neurorehabil Neural Repair OnlineFirst, published on July 26, 2010.

 

 

3.  Feasibility, Safety, and Efficacy of Directly Transplanting Autologous Adult Bone Marrow Stem Cells in Patients With Chronic Traumatic Dorsal Cord Injury.  A Pilot Clinical Study

 Osama S. Abdelaziz, Ahmed Marie, Mohamed Abbas, Mohamed Ibrahim, and Hala Gabr.  Neurosurg Q 2010;20:216–226.

 

4. Adjuvant dendritic cell-based tumour vaccination in patients with malignant glioma.  Beltagy M, Eissa A, Ali A, Elghoneimy E, Gabr H, Zayed R, Fouad N. CairoUniversityMed. J. June 2010.

 

5. The effect of freezing on the recovery and expansion of umbilical cord blood hematopoeitic stem cells.  El-Beshlawy A, Gabr H, Abdel-Khalek, K, Zayed R, Hammoud R, and Moussa S.  Experimental and Clinical Transplantation 1:50-55, 2009.

 

6.  Evaluation of the clinical efficacy of autologous bone-marrow derived hepatocyte injection in jliver cirrhosis patients:  a Phase II clinical trial.  Gabr H, Abo Saif M, El-Garem N, Sleman M, Zaky S.  ISSCR 7th annual meeting, 2009.

 

7.  Correction of Aberrant Pre-mRNA Splicing by Antisense Oligonucleotides in beta-Thalassemia Egyptian Patients with IVSI-110 Mutation.

[My paper] Amal El-Beshlawy, Azza Mostafa, Ilham Youssry, Hala Gabr, Iman Mansour,Manar El-Tablawy, Mona Aziz, Ibtissam Hussein

J Pediatr Hematol Oncol. 2008 Apr ;30 (4):281-284 .

 

8. Bone Marrow Derived Cell Transplantation in Patients with Decompensated Cirrhosis: A Preliminary Study
Nouman El-Garem1, Mona Amin Soliman, Hala Gabr, Nagwa Ramadan.

A.J. Gastroentrol.  Vol 9 no. 2. 2008; 9(2):44-48 ICID: 868128.

 

9.  Gomaa F, Gabr H, Soda S:  P-selectin expression and GPIIb/IIIa polymorphism in congenital cyanotic heart disease:  relevance to palliative systemic-pulmonary shunt and haemostatic parameters.  Int Acad. Cardiol 431-436, 2007.

 

10. Oral presentation " Stem cell Therapy in Spinal cord Injuries"  in the Third International Congress of Regenerative Medicine, Leipzig, Germany, 17-19 October,2007.

 

11. Oral presentation " Autologous bone marrow derived stem cells in liver cell failure" in the Third International Congress of Regenerative Medicine, Leipzig, Germany, 17-19 October,2007.

 

12. Oral presentation:"Autologous bone marrow derived hepatocytes in endstage liver cell failure".  12th International Symposium on Viral Hepatitis and Liver Diseases, 2006.

 

13.  Generation of dendritic cells from acute myeloid leukemia blasts.  Eyada T, Gabr H, Shahin N, Zayed R, Elmessery L, Salah N.  Egyp J Int Med.  January 2006.

 

14.   Evaluation of the inhibitory effect of antisense oligodeoxynucleotides on the growth of hepatitis C-associated hepatocellular carcinoma cells in vitro

Mona A AMIN, Mohamed R AWADEIN& Hala GABR

Chin J Dig Dis 2005 (Vol. 6, Issue 3, Pages 142-8).

 

15.  Purging of Philadelphia-positive cells in CML using liquid culture system Ansary,M, Gabr H, Tabalawy M, Nabil H, El-Meseery L, Shahin N:.  E. J. Lab Medicne, Feb-June, 2005.

 

16.  In-vitro characteristics of human cord blood and bone marrow-derived megakaryocytes:  a comparative study Gabr H, Abo Elew S:  .  E. J. Lab Med 17(2): 34-40. 2005.

 

17. Cytogenetic sensitivity:  induction and prevention in Fanconi anemia and acquired aplastic anemia, a comparative study.   Anasary M, Gabr H, Tablawy M, Salah N, Kamal M:  Gaz Egyp Ped 53(1,2) Jan-April, 2005.

 

18. Ex-vivo expansion of myeloid progenitor cells from fresh unselected human cord blood Zoheir N, Gabr H, Tablawy M, Leheta N:  .  E. J. Lab Med 15(3): 112-123 2005.

 

19. In-vitro use of plamids cloned with normal B-globin gene and LCR to induce normal B-chain expression by diseased red cell progenitors. Gabr H, Mahgoub E, Shehy O, Salah N E. J. Lab Med 16(3):579-590, 2004.

 

20.  In-vitro inhibition of BCR-ABL expression with antisense oligonucleotides as evident by proliferation inhibition of chronic myelogenous leukemia hematopoietic progenitors.  Ansary M, Gabr H, Tablawy M, Nour H:  E. J. Lab Med 15 (3): 661-679 2003.

 

  1. Identification of 9p-using FISH technique as an adverse risk factor in ALL.Gabr H, Mahgoub E, Abbas O, Mousa K:  E.J. Lab Med 15(3):575-588, 2003.
  2. The effect of freezing on the recovery and expansion of umbilical cord blood hematopoeitic stem cells.  Beshlawy AE, Metwally HG, Khalek KA, Hammoud RF, Mousa SM.  Exp Clin Transplant Mar; 7(1):50-6, 2009.
  3. Limb salvage using intramuscular injection of unfractionated autologous bone marrow mononuclear cells in critical limb ischemia:  a prospective pilot clinical trial.  Gabr H, Hedayet A, Imam U, Nasser M.  Exp. Clin Transplant Jun; 9(3):197-202, 2011.

.

  1. Clinical and laboratory evaluation of patients with endstage liver cell failure injected with bone marrow-derived hepatocyte-like cells.  Amer ME, El-Sayed SZ, El-Kheir WA, Gabr H, Gomaa AA, El-Noomani N, Hegazy M.  Eur J Gastroenterol Hepatol Oct; 23(10):936-41, 2011.

 

 

 

 

 

 

 

 

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