Publications

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2023
Elkholy, N. S., H. S. Mohammed, and M. W. Shafaa, "Assessment of the therapeutic potential of lutein and beta-carotene nanodispersions in a rat model of fibromyalgia", Scientific Reports, vol. 13, issue 1: Nature Publishing Group UK London, pp. 19712, 2023. Abstract
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MOHAMAD, E. B. T. E. S. A. M. A., A. M. Shehata, A. M. Abobah, A. T. Kholief, M. A. Ahmed, M. E. Abdelhakeem, N. K. Dawood, and H. S. Mohammed, "Chitosan-based films blended with moringa leaves and MgO nanoparticles for application in active food packaging", International Journal of Biological Macromolecules, vol. 253: Elsevier, pp. 127045, 2023. Abstract
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Eid, M. A., H. S. Mohammed, A. M. Abdelaal, and T. S. Taha, "Effect of collimator scatter factors on dose calculation of different breast cancer cases in radiotherapy", International Journal of Radiation Research, vol. 21, issue 3: Novin Medical Radiation Institute, pp. 553-560, 2023. Abstract
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Tharwat, E. K., A. O. Abdelaty, A. I. Abdelrahman, H. Elsaeed, A. Elgohary, A. S. El-Feky, Y. M. Ebrahim, A. Sakraan, H. A. Ismail, and Y. A. Khadrawy, "Evaluation of the therapeutic potential of cerebrolysin and/or lithium in the male Wistar rat model of Parkinson’s disease induced by reserpine", Metabolic Brain Disease, vol. 38, issue 5: Springer US New York, pp. 1513-1529, 2023. Abstract
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Ashoor, O., H. S. Mohammed, N. M. Radwan, and R. Elge-Baly, "Long-term serotonin abnormalities in the brain of immature rats subjected to febrile seizures", Iranian Journal of Basic Medical Sciences, vol. 26, issue 9: Mashhad University of Medical Sciences, pp. 1068, 2023. Abstract
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Elkholy, N. S., M. L. M. Hariri, H. S. Mohammed, and M. W. Shafaa, "Lutein and β-carotene characterization in free and nanodispersion forms in terms of antioxidant activity and cytotoxicity", Journal of Pharmaceutical Innovation, vol. 18: Springer US, pp. 1727–1744, 2023. Abstract
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Eman E Alshial, M. I. Abdulghaney, A. - H. S. Wadan, M. A. Abdellatif, N. E. Ramadan, A. M. Suleiman, N. Waheed, M. Abdellatif, and H. S. Mohammed, "Mitochondrial dysfunction and neurological disorders: A narrative review and treatment overview", Life Sciences: Pergamon, pp. 122257, 2023. Abstract
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Ali, O. A., H. S. E. Mohamed, N. M. Radwan, and R. H. Elgebaly, "Persistent changes in the brain of Immature Rats Experiencing febrile seizures", Egyptian Journal of Chemistry, vol. 66, issue 12: National Information and Documentation Centre (NIDOC), Academy of Scientific …, pp. 347-351, 2023. Abstract
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Hamdy, O., and H. S. Mohammed, "Post-heating Fluorescence-based Alteration and Adulteration Detection of Extra Virgin Olive Oil", Journal of Fluorescence, vol. 33: Springer US, pp. 1631–1639, 2023. Abstract
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Mohammed, H. S., "Selenium use in epilepsy", Vitamins and Minerals in Neurological Disorders: Academic Press, pp. 245-261, 2023. Abstract
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Mohammed, H. S., E. N. Hosny, H. G. Sawie, and Y. A. Khadrawy, "Transcranial photobiomodulation ameliorates midbrain and striatum neurochemical impairments and behavioral deficits in reserpine-induced parkinsonism in rats", Photochemical & Photobiological Sciences, vol. 22, issue 12: Springer International Publishing Cham, pp. 2891-2904, 2023. Abstract
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2022
Tareq, M., Y. A. Khadrawy, M. M. Rageh, and H. S. Mohammed, "Dose-dependent biological toxicity of green synthesized silver nanoparticles in rat’s brain", Scientific Reports, vol. 12, issue 1: Nature Publishing Group UK London, pp. 22642, 2022. Abstract
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Mohammed, H. S., "Effects of Wireless Communication Electromagnetic Fields on Human and Animal Brain Activity", Electromagnetic Fields of Wireless Communications: Biological and Health Effects: CRC Press, pp. 275-296, 2022. Abstract
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MOHAMAD, E. B. T. E. S. A. M. A., K. A. Ahmed, and H. S. Mohammed, "Evaluation of the skin protective effects of niosomal-entrapped annona squamosa against UVA irradiation", Photochemical & Photobiological Sciences, vol. 21, issue 12: Springer International Publishing Cham, pp. 2231-2241, 2022. Abstract
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Mosilhy, E. A., Eman E Alshial, M. M. Eltaras, M. M. A. Rahman, H. I. Helmy, A. H. Elazoul, O. Hamdy, and H. S. Mohammed, "Non-invasive transcranial brain modulation for neurological disorders treatment: a narrative review", Life Sciences, vol. 307: Pergamon, pp. 120869, 2022. Abstract
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2021
OS, H., K. MM, K. IM, and M. HS, " Development of a new Python- based cardiac phantom for myocardial SPECT imaging. ", Ann Nucl Med., vol. 35, issue 1, pp. 47-58, 2021.
YA, K., H. EN, M. M, and M. HS, "Antidepressant effects of curcumin-coated iron oxide nanoparticles in a rat model of depression", Eur J Pharmacol., vol. 908, pp. 174384, 2021.
NS, E., S. MW, and M. HS, "Cationic liposome-encapsulated carotenoids as a potential treatment for fibromyalgia in an animal model", Biochim Biophys Acta Mol Basis Dis., vol. 1867, issue 1, pp. 166150, 2021.
HS, M., and K. YA, "Electrophysiological and neurochemical evaluation of the adverse effects of REM sleep deprivation and epileptic seizures on rat's brain. ", Life Sci., vol. 273, pp. 119303, 2021.
HS, M., H. HM, Z. MH, M. H, and M. EA, "Linear and non- linear feature extraction from rat electrocorticograms for seizure detection by support vector machine.", Biomedical Eng, vol. 66, issue 6, pp. 563-572, 2021.
YA, K., H. EN, and M. HS, "Protective effect of nanocurcumin against neurotoxicity induced by doxorubicin in rat's brain. ", Neurotoxicology, vol. 85, pp. 1-9, 2021.
Mohamed, N., O. E. A. Hessen, and H. S. Mohammed, "Thermal stability, paramagnetic properties, morphology and antioxidant activity of iron oxide nanoparticles synthesized by chemical and green methods", Inorganic Chemistry Communications, vol. 128, pp. 108572, 2021.
2020
Elkholy, N. S., M. W. Shafaa, and H. S. Mohammed, "Biophysical characterization of lutein or beta carotene-loaded cationic liposomes", RSC Adv., vol. 10: The Royal Society of Chemistry, pp. 32409-32422, 2020. AbstractWebsite

The interactions between carotenoids and membrane constituents are vital for understanding the mechanism of their dynamic action. Lutein and beta-carotene were loaded separately into the bilayer of dipalmitoylphosphatidylcholine (DPPC) mixed at a molar ratio with l-α-phosphatidylethanolamine derived from sheep brain (cephalin) and stearylamine (SA) to form cationic liposomes. The molecular interaction between lutein or beta-carotene with cationic liposomes was studied using transmission electron microscopy (TEM){,} dynamic light scattering (DLS){,} differential scanning calorimetry (DSC){,} and Fourier transform infrared (FTIR) spectroscopy. Encapsulation efficiency (EE %) and in vitro drug release were determined. The DLS measurements confirmed the mono-dispersity of all samples. TEM results revealed that liposomal samples were oval-shaped and there was a change in their morphology and size upon encapsulation of lutein or beta-carotene. Beta-carotene was observed to adhere to the boundary surface within the liposomal assembly with external morphological alterations. EE% of lutein and beta-carotene exceeded 98.8 ± 0.3% and 87 ± 4%{,} respectively. Lutein doped with cationic liposomes shows better in vitro release stability (about 30%) than beta-carotene (about 45%) between the 3rd and the 6th hour manifested by lower leakage rate percentage of lutein which would lead to higher lutein retention. The incorporated lutein resulted in broadening and shifting of the major endothermic peak of the co-liposomes{,} while the incorporation of beta-carotene did not induce a noticeable shift. An FTIR study was employed to reveal structure alterations in the vesicles after the encapsulation of lutein or beta-carotene into liposomes. Encapsulation of lutein or beta-carotene into liposomes induced a change in the frequency of the symmetric and asymmetric CH2 stretching bands in the acyl chain that may influence the order of the membrane.

Mohammed, H. S., E. N. Hosny, Y. A. Khadrawy, M. Magdy, Y. S. Attia, O. A. Sayed, and M. AbdElaal, "Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat.", Biochimica et biophysica acta. Molecular basis of disease, vol. 1866, issue 5, pp. 165665, 2020. Abstract

The present study designed to investigate the protective effect of curcumin nanoparticles (CUR-NPs) on the cardiotoxicity induced by doxorubicin. Rats were divided into four groups; control, rats treated daily with CUR-NPs (50 mg/kg) for 14 days, rats treated with an acute dose of doxorubicin (20 mg/kg) and rats treated daily with CUR-NPs for 14 days injected with doxorubicin on the 10th day. After electrocardiogram (ECG) recording from rats at different groups, rat decapitation was carried out and the heart of each rat was excised out to measure the oxidative stress parameters; lipid peroxidation (MDA), nitric oxide (NO) and reduced glutathione (GSH) and the activities of Na,K,ATPase and acetylcholinesterase (AchE). In addition, the levels of dopamine (DA), norepinephrine (NE) and serotonin (5-HT) were determined in the cardiac tissues. Lactate dehydrogenase (LDH) activity was measured in the serum. The ECG recordings indicated that daily pretreatment with CUR- NPs has prevented the tachycardia (i.e. increase in heart rate) and ameliorated the changes in ST wave and QRS complex induced by doxorubicin. In addition, CUR-NPs prevented doxorubicin induced significant increase in MDA, NO, DA, AchE and LDH and doxorubicin induced significant decrease in GSH, NE, 5-HT and Na,K,ATPase. According to the present findings, it could be concluded that CUR-NPs have a protective effect against cardiotoxicity induced by doxorubicin. This may shed more light on the importance of CUR-NPs pretreatment before the application of doxorubicin therapy.

2019
Abdel-Razek, Y. A., O. A. Desouky, A. A. Elshenawy, A. S. Nasr, H. S. Mohmmed, and A. A. Elsayed, "Additive Effective Dose Rates during Chemical Processing of Natural Minerals", Radiochemistry, vol. 61, issue 3, pp. 373-380, 2019.
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