Publications

Export 9 results:
Sort by: Author [ Title  (Asc)] Type Year
A B [C] D E F G H I J K L M N O P Q R S T U V W X Y Z   [Show ALL]
C
Hegab, M. M., A. F. Abdelwahab, A. E. - S. M. Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, and S. M. Ibrahim, "CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians", Human immunology, vol. 77, issue 6: Elsevier, pp. 522-526, 2016. Abstract
n/a
Hegab, M. M., A. F. Abdelwahab, A. M. El-Sayed Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, S. M. Ibrahim, et al., "CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians", Human Immunology, vol. 77, issue 6: Elsevier Inc., pp. 522 - 526, 2016. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
n/a
Hegab, M. M., A. F. Abdelwahab, A. M. El-Sayed Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, S. M. Ibrahim, et al., "CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians.", Human immunology, vol. 77, issue 6, pp. 522-6, 2016 Jun. Abstract

OBJECTIVE: Limited data are available on the genetics of rheumatoid arthritis (RA) in Egyptians. Therefore, we investigated whether the confirmed genetic risk factors for RA in Europeans and/or Asians contribute to RA susceptibility in Egyptians.

SUBJECTS AND METHODS: A set of seven single-nucleotide polymorphisms (SNPs) in the vicinity of CD28, TNFAIP3, PTPN22, PADI4 and HLA-DRA were tested in a large multi-centric RA cohort in Egypt, consisting of 394 cases and 398 matched controls. Patients were stratified based on the positivity of either anti-citrullinated protein antibodies (ACPAs) or rheumatoid factor (RF).

RESULTS: Significant association was evident for three SNPs in this cohort: the CD28 (rs1980422) variant showed a strong association in the whole cohort (P=0.000119) and in seropositive subsets of the disease (PACPA+=0.004; PRF+=0.0005). Upon stratification, the PTPN22 (rs2476601) and TNFAIP3(rs5029939) variants showed association only with ACPA positive (PACPA+=0.00573) and negative (PACPA-=0.00999) phenotypes, respectively.

CONCLUSION: Our results suggest that CD28(rs1980422) and PTPN22(rs2476601) contribute to RA-susceptibility in Egyptians. Failure to replicate the association of PADI4(rs2240340)/(PADI4_94) in Egyptian RA patients provides further support for the notion that genetic architecture of RA is different in multiple populations of European, Asian, African, and Middle Eastern ancestries. Further investigation using large-scale studies is thus needed to maximize the power of genetic association.

Ragab, G., "Chapter 15: Vasculitic manifestations in the gastrointestinal tract", Vasculitis: Oxford University Press, pp. 181-198, 2008. Abstract
n/a
DeVore, A. E., J. L. Jorizzo, N. Vigneswaran, B. K. Rodu, S. Onal, S. C. Foster, S. K. Frankel, M. I. Schwarz, S. J. Oh, G. Ragab, et al., "Clinical manifestations common to vasculitis", Vasculitis: Oxford University Press, pp. 115, 2007. Abstract
n/a
DeVore, A. E., J. L. Jorizzo, N. Vigneswaran, B. K. Rodu, S. Onal, S. C. Foster, S. K. Frankel, M. I. Schwarz, S. J. Oh, and G. Ragab, "Clinical manifestations common to vasculitis", Vasculitis: Oxford University Press, pp. 115, 2007. Abstract
n/a
Hegab, M. M., A. F. Abdelwahab, J. M. Rudolph, A. M. El-Sayed Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, et al., "Corrigendum to ?CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians? [Hum. Immunol. 77 (2016) 522?526] (S0198885916300684), (10.1016/j.humimm.2016.04.018))", Human Immunology, vol. 78, no. 7-8, 2017. Abstract
n/a
Hegab, M. M., A. F. Abdelwahab, J. M. Rudolph, A. M. El-Sayed Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, et al., "Corrigendum to “CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians” [Hum. Immunol. 77 (2016) 522–526] (S0198885916300684), (10.1016/j.humimm.2016.04.018))", Human Immunology, vol. 78, issue 7-8: Elsevier Inc., pp. 521, 2017. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
n/a
Hegab, M. M., A. F. Abdelwahab, J. M. Rudolph, A. E. - S. M. Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, and W. Abouraya, "Corrigendum to" CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians"[Hum. Immunol. 77 (2016) 522-526]", Human immunology, vol. 78, issue 7-8, pp. 521, 2017. Abstract
n/a
Tourism