Publications

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Hamza, M. M. E., T. A. Macky, M. K. Sidky, G. Ragab, and M. M. Soliman, "Intravitreal infliximab in refractory uveitis in Behçet's disease: a safety and efficacy clinical study", Retina, vol. 36, issue 12: LWW, pp. 2399-2408, 2016. Abstract
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Hamza, M. M. E., T. A. Macky, M. K. Sidky, G. Ragab, and M. M. Soliman, "Intravitreal infliximab in refractory uveitis in Behcet's disease: A safety and efficacy clinical study", Retina, vol. 36, issue 12: Lippincott Williams and Wilkins, pp. 2399 - 2408, 2016. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Hegab, M. M., A. F. Abdelwahab, A. M. El-Sayed Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, S. M. Ibrahim, et al., "CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians", Human Immunology, vol. 77, issue 6: Elsevier Inc., pp. 522 - 526, 2016. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Hegab, M. M., A. F. Abdelwahab, J. M. Rudolph, A. E. - S. M. Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, and W. Abouraya, "Corrigendum to" CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians"[Hum. Immunol. 77 (2016) 522-526]", Human immunology, vol. 78, issue 7-8, pp. 521, 2017. Abstract
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Hegab, M. M., A. F. Abdelwahab, A. E. - S. M. Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, and S. M. Ibrahim, "CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians", Human immunology, vol. 77, issue 6: Elsevier, pp. 522-526, 2016. Abstract
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Hegab, M. M., A. F. Abdelwahab, A. M. El-Sayed Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, S. M. Ibrahim, et al., "CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians.", Human immunology, vol. 77, issue 6, pp. 522-6, 2016 Jun. Abstract

OBJECTIVE: Limited data are available on the genetics of rheumatoid arthritis (RA) in Egyptians. Therefore, we investigated whether the confirmed genetic risk factors for RA in Europeans and/or Asians contribute to RA susceptibility in Egyptians.

SUBJECTS AND METHODS: A set of seven single-nucleotide polymorphisms (SNPs) in the vicinity of CD28, TNFAIP3, PTPN22, PADI4 and HLA-DRA were tested in a large multi-centric RA cohort in Egypt, consisting of 394 cases and 398 matched controls. Patients were stratified based on the positivity of either anti-citrullinated protein antibodies (ACPAs) or rheumatoid factor (RF).

RESULTS: Significant association was evident for three SNPs in this cohort: the CD28 (rs1980422) variant showed a strong association in the whole cohort (P=0.000119) and in seropositive subsets of the disease (PACPA+=0.004; PRF+=0.0005). Upon stratification, the PTPN22 (rs2476601) and TNFAIP3(rs5029939) variants showed association only with ACPA positive (PACPA+=0.00573) and negative (PACPA-=0.00999) phenotypes, respectively.

CONCLUSION: Our results suggest that CD28(rs1980422) and PTPN22(rs2476601) contribute to RA-susceptibility in Egyptians. Failure to replicate the association of PADI4(rs2240340)/(PADI4_94) in Egyptian RA patients provides further support for the notion that genetic architecture of RA is different in multiple populations of European, Asian, African, and Middle Eastern ancestries. Further investigation using large-scale studies is thus needed to maximize the power of genetic association.

Hegab, M. M., A. F. Abdelwahab, J. M. Rudolph, A. M. El-Sayed Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, et al., "Corrigendum to “CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians” [Hum. Immunol. 77 (2016) 522–526] (S0198885916300684), (10.1016/j.humimm.2016.04.018))", Human Immunology, vol. 78, issue 7-8: Elsevier Inc., pp. 521, 2017. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Hegab, M. M., A. F. Abdelwahab, J. M. Rudolph, A. M. El-Sayed Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, et al., "Corrigendum to ?CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians? [Hum. Immunol. 77 (2016) 522?526] (S0198885916300684), (10.1016/j.humimm.2016.04.018))", Human Immunology, vol. 78, no. 7-8, 2017. Abstract
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Hegazy, M. T., W. R. Allam, M. A. Hussein, N. Zoheir, L. Quartuccio, S. F. El-Khamisy, and G. Ragab, "Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs", EBioMedicine, vol. 35: Elsevier, pp. 106-113, 2018. Abstract
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Hegazy, M. T., A. Fayed, T. El Shabony, M. Visentini, D. Saadoun, P. Cacoub, and G. Ragab, "Relapsing Cryoglobulinemic Vasculitis Following Successful HCV Eradication by Interferon-Free Direct Acting Antivirals, an International Multicenter Study", ARTHRITIS & RHEUMATOLOGY, vol. 71: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2019. Abstract
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Hegazy, M. T., M. A. Hussein, L. Quartuccio, M. Fawzy, N. Zoheir, M. I. Ellawindi, M. Bond, C. Mazzaro, A. E. Ray, and M. E. S. El Raziky, "Treatment of cryoglobulinemic vasculitis with sofosbuvir in four combination protocols", ARTHRITIS & RHEUMATOLOGY, vol. 68: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2016. Abstract
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Hegazy, M. T., W. R. Allam, M. A. Hussein, N. Zoheir, L. Quartuccio, S. F. El-Khamisy, G. Ragab, and M. C. C. the for the study of Vasculitis, "Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs", EBioMedicine, vol. 35: Elsevier B.V., pp. 106 - 113, 2018. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Hussein, M. A., M. I. Ellawindi, and G. Ragab, "Performance of classification criteria for Behcet's disease in an Egyptian cohort", Indian Journal of Rheumatology, vol. 12, issue 3: Medknow Publications, pp. 152, 2017. Abstract
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Hussein, M. A., A. El-Hindawi, and G. Ragab, "Everolimus in Erdheim–Chester disease", The Egyptian Journal of Internal Medicine, vol. 25, issue 3: SpringerOpen, pp. 159-163, 2013. Abstract
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Hussein, M., A. El-Hindawi, and G. Ragab, "Everolimus in Erdheim–Chester disease", The Egyptian Journal of Internal Medicine, vol. 25, issue 3, pp. 159 - 163, 2013/9/1. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ

A 43-year-old man presented with bony pains, repeated pathological fractures with overlying skin ulcerations, and forearm and chest wall swellings. Investigations led to the diagnosis of Erdheim–Chester disease. Treatment with low-dose prednisolone, oral everolimus, and zoledronic acid was started, with a marked improvement in his condition.

Hussein, M., M. Ellawindi, and G. Ragab, "Performance of classification criteria for Behcet's disease in an Egyptian cohort", Indian Journal of Rheumatology, vol. 12, issue 3: Medknow Publications, pp. 152 - 155, 2017. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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